Lifeboat Foundation

Powered by data produced by its AI-driven discovery platform, clinical-stage biotech BioAge Labs is rapidly developing a pipeline of therapies to extend healthy lifespan by targeting the molecular causes of aging. Having raised more than $120 million in funding, and with multiple clinical trials already under its belt, the company is focused on building a broad pipeline of potential longevity therapies in three main areas: muscle, immune, and brain aging.

Longevity. Technology: There are few companies in the longevity biotech field that appear to be executing on their vision as quickly and consistently as BioAge. When the company wowed the sector with a $90 million funding round in 2020, talk of multiple imminent clinical trials may have sounded optimistic to some, but BioAge has delivered on its promise time and again. Beyond the trials already underway, the company’s much-vaunted AI discovery platform also appears to be churning out the data, this year spawning a new programme exploring the potential of NLRP3 inhibitors in brain aging. To learn more, we caught up with BioAge co-founder and CEO Kristen Fortney.

Looking back at 2022, Fortney says it has been “immensely gratifying” to see so many new companies and investors coming into the longevity field.

In this #webinar, Dr Vincenzo Sorrentino from the Department of Biochemistry and Healthy Longevity Translational Research Programme at the Yong Loo Lin School of Medicine, shared about his research on the relationship between metabolism, nutrition and proteostasis and their impact on health and ageing, and engaged in discussion about the role of mitochondrial proteostasis in ageing and related diseases.

Register for upcoming #HealthyLongevity #webinar sessions at https://nus-sg.zoom.us/webinar/register/7916395807744/WN__sypkX6ZSomc7cGAkK3LbA

Continue reading “Targeting the mitochondria-proteostasis connection in ageing and disease | Dr Vincenzo Sorrentino” »

The research team reconstructed an ancestral enzyme by searching databases for corresponding modern enzymes, using the obtained sequences to calculate the original sequence, and introducing the corresponding gene sequence into lab bacteria to produce the desired protein. The enzyme was then studied in detail and compared to modern enzymes.

The research team, led by Professors Mario Mörl and Sonja Prohaska, focused on enzymes called tRNA nucleotidyltransferases, which attach three nucleotide building blocks in the sequence C-C-A to small RNAs (transfer RNAs) in cells. These RNAs are subsequently used to supply amino acids.

<div class=””> <div class=””><br />Amino acids are a set of organic compounds used to build proteins. There are about 500 naturally occurring known amino acids, though only 20 appear in the genetic code. Proteins consist of one or more chains of amino acids called polypeptides. The sequence of the amino acid chain causes the polypeptide to fold into a shape that is biologically active. The amino acid sequences of proteins are encoded in the genes. Nine proteinogenic amino acids are called “essential” for humans because they cannot be produced from other compounds by the human body and so must be taken in as food.<br /></div> </div>

Continue reading “Puzzling Biochemists for Decades: Reconstruction of Two-Billion-Year-Old Enzyme Solves a Long-Standing Mystery” »

According to a recent study conducted by scientists at the University of Miami Rosenstiel School of Marine, Atmospheric, and Earth Science, ships may be contributing to the spread of a deadly coral disease called stony coral tissue loss disease (SCTLD) throughout Florida and the Caribbean.

This disease, which was first detected near Miami in 2014, has now impacted coral reefs in Jamaica, St. Maarten, the U.S. Virgin Islands, and Belize, among other locations. The findings of this study may help researchers to develop testing and treatment methods that can reduce the risk of further disease transmission.

Researchers suggest that transport through ship hulls, where the vessel takes on ballast water in one region to keep it stable and releases it at a different port, may have contributed to disease spread.

Following China’s abrupt U-turn on zero-COVID policy last month, the country has seen an increase in COVID cases. A leading doctor at one of Shanghai’s top hospitals estimates that up to 70% of the city’s population has been infected with COVID-19.

VALL-E can generate various outputs with the same input text while maintaining the speaker’s emotion and the acoustical prompt. VALL-E can synthesise natural speech with high speaker accuracy by prompting in the zero-shot scenario. According to evaluation results, VALL-E performs much better on LibriSpeech and VCTK than the most advanced zero-shot TTS system. VALL-E even achieved new state-of-the-art zero-shot TTS results on LibriSpeech and VCTK.

It is interesting to note that people who have lost their voice can ‘talk’ again through this text-to-speech method if they have previous voice recordings of themselves. Two years ago, a Stanford University Professor, Maneesh Agarwala, also told AIM that they were working on something similar, where they had planned to record a patient’s voice before the surgery and then use that pre-surgery recording to convert their electrolarynx voice back into their pre-surgery voice.

UnHerd’s Freddie Sayers meets PayPal Co founder David Sacks.

Read the accompanying article:
https://unherd.com/thepost/david-sacks-the-tech-purge/

Continue reading “David Sacks: The tech reset has only just begun” »

Interesting interview about the future of Ageing with leading expert with Aubrey De Grey.

This week we interview the phenomenal Aubrey De Grey, the world’s foremost authority on longevity and developing strategies to slow or eliminate aging altogether. The author of The Mitochondrial Free Radical Theory of Aging (1999) and Ending Aging (2007), De Grey is probably best known for the concept of Longevity Escape Velocity, a view that soon medical technology will enable human beings to prevent age-related deterioration, and eventually eliminated aging entirely.

The future of Ageing with Aubrey De Grey.

An international research team has discovered a potential new target for a drug that could prevent the deadly metastases responsible for 90% of cancer deaths.

According to a study published in Nature, an international team of researchers has identified a mechanism that allows cancer cells to spread throughout the body. They found that cancer cells move faster when they are surrounded by thicker fluids, a change that occurs when lymph drainage is disrupted by a primary tumor.

These findings provide a potential new target for stopping metastasis, which is responsible for 90% of cancer deaths.

Continue reading “New Study Uncovers Potential Target for Stopping 90% of Cancer Deaths” »