Xiaojia Li et al. demonstrated that Plakophilin 3 is transformed from a structural protein into an oncogenic molecule, driving acinar cell transformation and promoting cancer initiation and progression in the pancreas through FOXM1 protein stabilization.

Clinical obesity, as newly defined by excess adiposity and organ dysfunction, was linked to greater all-cause and cause-specific mortality risk in the UK Biobank cohort.

This study evaluates the association between a new definition of obesity with mortality data in the UK Biobank.

Zhang et al. construct a comprehensive microbial genome catalog from the Qinghai-Xizang Plateau lakes, with 80.78% of genomes representing previously undescribed taxa. Their research provides not only a holistic genomic resource for bioprospecting, but also suggests key salinity adaptation strategies, particularly the dominant role of glycine betaine uptake in hypersaline environments.

Ye et al. reveal how VMAT2 loads monoamine neurotransmitters into storage vesicles and interacts with neurological drugs, facilitated by the structural flexibility of the transporter. Amphetamine directly triggers monoamine release to induce psychostimulation, likely by bypassing the regular transport cycle. These insights elucidate psychostimulant action and inform therapeutic strategies.

This single-patient case report provides Class IV evidence that oral tenofovir alafenamide fumarate might stabilize the clinical course in patients with progressive multifocal leukoencephalopathy.