Results of a large, global clinical trial spanning five continents with over 1,700 patients with bronchiectasis, published this April in the New England Journal of Medicine, demonstrated benefits of an investigational, once-a-day pill called brensocatib as a therapy for the chronic lung condition.

The clinical trial findings are important, as there are currently no FDA-approved medications for bronchiectasis, a chronic condition with persistent lung airway inflammation and infection. Bronchiectasis can often stem from various injuries to the airways causing the ‘bronchial’ tubes leading to the lungs to become permanently enlarged, and more prone to infection and chronic inflammation.

This Review summarizes advances in mass-spectrometry-based proteomics and explores the potential applications of these technologies in the clinic.

In a study published in the journal Frontiers in Pharmacology, researchers have discovered that a sugar called 2-deoxy-D-ribose (2dDR), which plays a fundamental role in various biological processes both in animals and humans, can stimulate hair to regrow in mice.

Over the past eight years, scientists from Sheffield and COMSATS University Pakistan have been studying how the sugar can help to heal wounds by promoting the formation of new blood vessels. During the research, the team also noticed that hair around the healing wounds appeared to grow more quickly compared to those that hadn’t been treated.

To explore this further, the scientists established a model of testosterone driven hair loss in mice — similar to the cause of pattern baldness in men. The team found that applying a small dose of the naturally occurring sugar helped to form new blood vessels, which led to hair regrowing.

Findings from the study show that the deoxy ribose sugar is as effective at regrowing hair as Minoxidil — an existing drug used to treat hair loss. However, the research offers a potential alternative approach to stimulating hair growth through a naturally occurring deoxy ribose sugar-from 2024.

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The key to curing male pattern baldness — a condition that affects up to 50 per cent of men worldwide — could lie in a sugar that naturally occurs in the human body, according to scientists at the University of Sheffield.

Scientists may have identified a way to naturally regulate blood sugar levels and sugar cravings in a similar fashion to drugs like Ozempic.

In mice and humans, the key to unlocking this natural process was found to be a gut microbe and its metabolites – the compounds it produces during digestion.

By increasing the abundance of this one gut microbe in diabetic mice, researchers led by a team at Jiangnan University in China showed they can “orchestrate the secretion of glucagon-like peptide-1”

At AACR in Chicago, Ernexa unveiled new data on its novel stem cell approach to treating ovarian cancer.

This study was conducted to efficiently produce virus-like particles (VLPs) of enterovirus 71 (EV71), a causative virus of hand, foot, and mouth disease (HFMD). The expression level of the P1 precursor, a structural protein of EV71, was modified to increase VLP production, and the optimal expression level and duration of the 3CD protein for P1 cleavage were determined. The expression level and duration of 3CD were controlled by the p10 promoter, which was weakened by repeated burst sequence (BS) applications, as well as the OpIE2 promoter, which was weakened by the insertion of random untranslated region sequences of various lengths. The cleavage and production efficiency of the P1 precursor were compared based on the expression time and level of 3CD, revealing that the p10-BS5 promoter with four repeated BSs was the most effective. When P1 and 3CD were expressed using the hyperexpression vector and the p10-BS5 promoter, high levels of structural protein production and normal HFMD-VLP formation were observed, respectively. This study suggests that the production efficiency of HFMD-VLPs can be significantly enhanced by increasing the expression of the P1 precursor and controlling the amount and duration of 3CD expression.