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Resting and activated T cell states are established by context-specific regulators and dynamic gene circuits.

A specialized technology can restore and preserve microcirculation and cellular functions hours post-mortem in an isolated pig brain.

New research looking at the stem cells of ‘superagers’ — people aged 100 or more — could make it possible for more people to live a longer and healthier life.

The Call is still open on senescence in brain aging and Alzheimers disease!

Submit your paper today! 📩

Understanding Senescence in Brain Aging and Alzheimer’s Disease

Guest Editors Drs. Julie Andersen and Darren Baker, Associate Editor Dr. Anna Csiszar and Editor-in-Chief Dr. Zoltan Ungvari, and the editorial team of GeroScience (Journal of the American Aging Association; 2018 Impact Factor: 6.44) invite submission of original research articles, opinion papers and review articles related to research focused on understanding the role of senescence in brain aging and in Alzheimer’s disease. Senescent cells accumulate in aging and pathological conditions associated with accelerated aging. While earlier investigations focused on cellular senescence in tissues and cells outside of the brain (e.g. adipose tissue, dermal fibroblasts, cells of the cardiovascular system), more recent studies started to explore the role of senescent cells in age-related decline of brain function and the pathogenesis of neurodegenerative disease and vascular cognitive impairment. This call-for-papers is aimed at providing a platform for the dissemination of critical novel ideas related to the functional and physiological consequences of senescence in diverse brain cell types (e.g., oligodendrocytes, pericytes, astrocytes, endothelial cells, microglia, neural stem cells), with the ultimate goal to identify novel targets for treatment and prevention Alzheimer’s disease, Parkinson’s disease and vascular cognitive impairment. We welcome manuscripts focusing on senescent-cell-targeting mouse models, the role of paracrine senescence, senescence pathways in terminally differentiated neurons, the pleiotropic effects of systemic senescence, the role of senescence in neuroinflammation and the protective effects of senolytic therapies. We are especially interested in manuscripts exploring the causal role of molecular mechanisms of aging in induction of cellular senescence as well as links between lifestyle (e.g., diet, exercise, smoking), medical treatments (e.g. cancer treatments), exposure environmental toxicants and cellular senescence in the brain. We encourage submission of manuscripts on developing innovative strategies to identify and target senescent cells for prevention/treatment of age-related diseases of the brain. Authors are also encouraged to submit manuscripts focusing on translational aspects of senescence research.

Continue reading “GeroScience: 📢CallForPapers” »

- is focusing on the role of molecular mechanisms of aging in the pathogenesis of cardiovascular diseases, COVID19, hypertension, obesity and vascularhomeostasis. ‘ + Read more in the comments and submit📧 at the link⬇

Cell Biology of Vascular Aging.

Guest Editors: Prof. Zoltan Arany, Prof. Jalees Rehman and Prof. Gabor Csanyi.

Deputy Editor Dr. Stefano Tarantini and Editor-in-Chief Dr. Zoltan Ungvari, and the editorial team of GeroScience (Official Journal of the American Aging Association, published by Springer) invite submission of original research articles, opinion papers and review articles related to research focused on understanding the mechanisms involved in vascular aging, the factors promoting accelerated aging in vascular cells and the role of vascular cells in the pathogenesis of age-related diseases. This call-for-papers is aimed at providing a platform for the dissemination of critical novel ideas related to the mechanisms of vascular aging as well as mechanisms related to key phenotypes of vascular aging including.

Continue reading “GeroScience: 📢 CallForPapers” »

Some early breast cancer patients can safely avoid specific surgeries, according to two studies exploring ways to lessen treatment burdens.

One new study, published in the New England Journal of Medicine, examines whether removing lymph nodes is always necessary in early breast cancer. Another in the Journal of the American Medical Association suggests a new approach to a type of breast cancer called ductal carcinoma in situ, or DCIS.

The research was discussed Thursday at the San Antonio Breast Cancer Symposium.

A study in mice has found that maternal gut microbiome composition during pregnancy has long-term effects on offspring stem cell growth and development. The researchers, headed by Parag Kundu, PhD, at the Institut Pasteur of Shanghai-Chinese Academy of Sciences, found that treating pregnant mice with the common gut microbe Akkermansia muciniphila resulted in offspring that had more active stem cells in both the brain and intestinal tract. As a result the offspring were less anxious and recovered quicker from colitis, and these differences were still evident at 10 months of age.

The team showed that Akkermansia muciniphila impacted stem cell growth by altering the abundance of other gut microorganisms and increasing the microbial production of metabolites that cross the placenta and induce stem cell growth and proliferation. Exposing offspring to the bacterium after birth did not result in the same stem cell activation.

“This is a major advancement in developing microbiota-based intervention strategies to improve child health,” said Kundu, who is senior author of the team’s published paper in Cell Stem Cell, titled “Maternal gut microbiota influence stem cell function in offspring.” In their report the team stated, “These results suggest a fundamental role of the maternal microbiome in programming offsprings’ stem cells and represent a promising target for interventions.”

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