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Category: biotech/medical – Page 57

“ tabindex=”0” acid reflux at a significantly faster rate than those without. This highlights the urgent need for a healthcare system that treats both mental and physical health together, rather than in isolation.

Depression’s Lasting Impact on Physical Health

Adults with a history of depression develop chronic physical conditions about 30% faster than those without, according to a study published on February 13 in PLOS Medicine. Researchers, led by Kelly Fleetwood from the University of Edinburgh, suggest that depression should be recognized as a “whole-body” condition, emphasizing the need for integrated care that addresses both mental and physical health.

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The same material from which you drink your morning coffee could transform the way scientists detect disease, purify water, and insulate space shuttles thanks to an entirely new approach to ceramic manufacturing.

Published in Advanced Science, 3D-AJP is an aerosol jet 3D nanoprinting technique that allows for the fabrication of highly complex ceramic structures that—at just 10 micrometers (a fraction of the width of human hair)—are barely visible to the naked eye. These 3D structures are made up of microscale features including pillars, spirals, and lattices that allow for controlled porosity, ultimately enabling advances in ceramic applications.

“It would be impossible to machine ceramic structures as small and as precise as these using traditional manufacturing methods,” explained Rahul Panat, professor of mechanical engineering at Carnegie Mellon University and the lead author of the study. “They would shatter.”

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Mitochondrial stress disrupts insulinInsulin is a hormone produced by the pancreas, crucial for regulating blood glucose levels. It helps cells in the body absorb glucose from the bloodstream and convert it into energy or store it for future use. Insulin production and action are essential for maintaining stable blood sugar levels. In people with diabetes, the body either does not produce enough insulin (Type 1 diabetes) or cannot effectively use the insulin it does produce (Type 2 diabetes), leading to elevated levels of glucose in the blood. This can cause various health complications over time, including heart disease, kidney damage, and nerve dysfunction. Insulin therapy, where insulin is administered through injections or an insulin pump, is a common treatment for managing diabetes, particularly Type 1. The discovery of insulin in 1921 by Frederick Banting and Charles Best was a landmark in medical science, transforming diabetes from a fatal disease to a manageable condition. tabindex=0 insulin production in diabetes, but reversing the damage may restore β-cell function.

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A nonverbal autistic child said his first words after taking a cheap drug normally given to cancer patients.

Mason Conner of Arizona was diagnosed with autism at two-and-a-half-years-old after his mother noticed he hadn’t started talking.

After years of failed therapies and treatments, Mason’s parents met with a doctor researching experimental new therapies for autism.

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It’s a breakthrough in cancer treatment, and UChicago Medicine is one of the first hospitals to offer it.

It’s not just one treatment, but can eventually become a whole new way to treat cancer.

Alla Pinzour has been fighting skin cancer for around 15 years—but not anymore.

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Cells have surface receptors called integrins that bind to repetitive domains present on the extracellular matrix (ECM) surrounding the cells, allowing them to grow and spread. A new study from the Department of Bioengineering (BE), Indian Institute of Science (IISc) and collaborators shows that tweaking the spacing between these binding domains on the ECM can boost the efficiency of ultrasound treatment applied to kill cancer cells.

“In a normal tissue, the spacing on the ECM is around 50–70 nanometers (nm), but in the , severe choking occurs due to excessive ECM secretion, which may reduce the binding spacing to below 50 nm,” explains Ajay Tijore, Assistant Professor in BE and corresponding author of a related study published in Nano Letters. “We found more being killed when the binding spacing is increased to around 50–70 nm.”

Low-frequency ultrasound waves (39 kHz) can disrupt the and trigger cell death in cancer cells. It is a relatively low-cost and non-invasive approach. Unlike normal cells, cancer cells do not have repair mechanisms that help them withstand the exerted by ultrasound waves.

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Mammoth Biosciences researchers have developed NanoCas, an ultracompact CRISPR nuclease, demonstrating its ability to perform gene editing in non-liver tissues, including skeletal muscle, using a single adeno-associated virus (AAV) vector. Experiments in non-human primates (NHPs) resulted in editing efficiencies exceeding 30% in muscle tissues.

CRISPR gene editing has revolutionized genetics, but delivery challenges have restricted its clinical applications primarily to ex vivo and liver-directed therapies. Conventional CRISPR nucleases, including Cas9 and Cas12a, exceed the packaging limits of a single AAV vector, necessitating dual-AAV strategies that reduce efficiency.

Smaller CRISPR systems such as Cas12i and CasX have been identified, but they remain too large or exhibit low editing efficiency. Existing compact systems like Cas14 and IscB have not demonstrated robust efficacy in large animal models.

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In 1978, parvovirus—then common to cats—started infecting dogs in Europe. The virus spread quickly around the globe, killing hundreds of thousands of dogs, mostly puppies—until a team of Cornell researchers led by the late Leland “Skip” Carmichael developed a vaccine, the derivatives of which are still used today.

“It was really at the time a worldwide relief, a miracle,” said Colin Parrish, interim director of the Baker Institute for Animal Health, who joined Carmichael’s lab as a graduate student in 1980 and is now senior author of a new study that continues to advance our understandings of the virus and how the vaccine works.

The paper, published Feb. 14 in Proceedings of the National Academy of Sciences, shows how host antibodies bind to parvovirus and neutralize it. The findings shed light on fundamental interactions between viruses and their hosts, and open new doors for improving current vaccines and treatments for infected animals.

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