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Category: biotech/medical – Page 47

Roll-to-roll method streamlines DNA sequencing with faster, more efficient fluidics

Researchers at Beijing Genomics and IMDEA Nanociencia institutes have introduced a novel method that could significantly accelerate efficiency and reduce the cost of handling fluidics in DNA sequencing.

Traditional DNA sequencing relies on flow cells, where liquid reagents are repeatedly pumped in and out for each of the sequencing reactions. For large-scale sequencing, this process involves immersing into reagents—a method that works well at industrial scale but is impractical for smaller labs or , where sample sizes are limited and drying effects become a problem.

The new approach turns that process on its head. Instead of pumping fluids through a chamber, the researchers use a roll-to-roll technique that gently shears the liquid across the surface. This dramatically improves efficiency, allowing reagents to be replaced more quickly and uses up to 85 times less material. As a result, DNA sequencing that once took days can now be completed in under 12 hours, with significantly lower costs.

New Open-Source Tool Makes Complex Data Easily Understandable

Datavzrd makes complex datasets interactive and easy to use. It works across scientific fields without programming knowledge. Tabular data is central to scientific research, whether in medicine, the social sciences, or archaeology. Yet transforming raw tables into something clear and usable is of

How to stay young at DNA level? Harvard research finds surprising link between daily supplement and longevity

A Harvard-affiliated study suggests that daily vitamin D supplementation may help slow biological aging by protecting DNA and preserving telomere length. The VITAL trial, which tracked over 1,000 adults for four years, found that participants taking 2,000 IU of vitamin D daily experienced less telomere shortening, effectively reducing biological aging by nearly three years.

Precise tissue deformation measurement technique promises better-fitting sportswear and medical apparel

Soft tissue deformation during body movement has long posed a challenge to achieving optimal garment fit and comfort, particularly in sportswear and functional medical wear.

Researchers at The Hong Kong Polytechnic University (PolyU) have developed a novel anthropometric method that delivers highly to enhance the performance and design of compression-based apparel.

Prof. Joanne YIP, Associate Dean and Professor of the School of Fashion and Textiles at PolyU, and her research team pioneered this anthropometric method using image recognition algorithms to systematically access tissue deformation while minimizing motion-related errors.

Pancreatic insulin disruption triggers bipolar disorder-like behaviors in mice, study shows

Bipolar disorder is a psychiatric disorder characterized by alternating episodes of depression (i.e., low mood and a loss of interest in everyday activities) and mania (i.e., a state in which arousal and energy levels are abnormally high). On average, an estimated 1–2% of people worldwide are diagnosed with bipolar disorder at some point during their lives.

Bipolar disorder can be highly debilitating, particularly if left untreated. Understanding the neural and physiological processes that contribute to its emergence could thus be very valuable, as it could inform the development of new prevention and treatment strategies.

In addition to experiencing periodic changes in mood, individuals diagnosed with this disorder often exhibit some metabolic symptoms, including changes in their blood sugar levels. While some previous studies reported an association between blood sugar control mechanisms and bipolar disorder, the biological link between the two has not yet been uncovered.

Why Do We Need Sleep? Oxford Scientists Trace the Answer to Mitochondria

Sleep may serve as more than rest for the mind; it may also function as essential upkeep for the body’s energy systems. A new study from University of Oxford researchers, published in Nature, shows that the drive to sleep is caused by electrical stress building up in the tiny energy-producing structures of brain cells.

This finding provides a concrete physical explanation for the biological need for sleep and has the potential to reshape scientific thinking about sleep, aging, and neurological disorders.

Puzzle-solving chemist helps boost synthesis of key bioactive compounds

A new approach to an established reaction boosts the ability to synthesize vinylic ethers—key building blocks for many molecules important to human health. The journal Organic Letters published the breakthrough, made by chemists at Emory University.

“Our method is easy to reproduce and is based on widely available and inexpensive compounds,” says San Pham, an Emory Ph.D. candidate and first author of the paper. “We can apply this method to make multiple natural products, including novel vinylic ethers.”

Her research improves the reliability, yield and generality of what is known as the Chan-Evans-Lam reaction. These enhancements greatly expand the reaction’s potential for the synthesis of complex, biologically active compounds for drug research.

Switching Off One Crucial Protein Appears to Reverse Brain Aging in Mice

A protein called ferritin light chain 1 (FTL1) may play a significant role in brain aging, a new study reveals, giving scientists a new target for understanding and potentially preventing brain deterioration and disease.

FTL1 was brought to light through a careful comparison of the hippocampus part of the brain in mice of different ages. The hippocampus is involved in memory and learning, and it is one of the regions that suffers most from age-related decline.

The study team found that FLT1 was the one protein in this region that old mice had more of and young mice had less of.

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