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AI used to design immune-safe ‘zinc finger’ proteins for gene therapy

Machine learning models have seeped into the fabric of our lives, from curating playlists to explaining hard concepts in a few seconds. Beyond convenience, state-of-the-art algorithms are finding their way into modern-day medicine as a powerful potential tool. In one such advance, published in Cell Systems, Stanford researchers are using machine learning to improve the efficacy and safety of targeted cell and gene therapies by potentially using our own proteins.

Most human diseases occur due to the malfunctioning of proteins in our bodies, either systematically or locally. Naturally, introducing a new therapeutic protein to cure the one that is malfunctioning would be ideal.

Although nearly all therapeutic protein antibodies are either fully human or engineered to look human, a similar approach has yet to make its way to other therapeutic proteins, especially those that operate in cells, such as those involved in CAR-T and CRISPR-based therapies. The latter still runs the risk of triggering immune responses. To solve this problem, researchers at the Gao Lab have now turned to machine learning models.

A semi-automated manufacturing process for cost-efficient quantum cascade laser modules

Resonantly tunable quantum cascade lasers (QCLs) are high-performance laser light sources for a wide range of spectroscopy applications in the mid-infrared (MIR) range. Their high brilliance enables minimal measurement times for more precise and efficient characterization processes and can be used, for example, in chemical and pharmaceutical industries, medicine or security technology. Until now, however, the production of QCL modules has been relatively complex and expensive.

The Fraunhofer Institute for Applied Solid State Physics IAF has therefore developed a semi-automated process that significantly simplifies the production of QCL modules with a MOEMS (micro-opto-electro-mechanical system) grating scanner in an external optical cavity (EC), making it more cost-efficient and attractive for industry. The MOEMS-EC-QCL technology was developed by Fraunhofer IAF in collaboration with the Fraunhofer Institute for Photonic Microsystems IPMS.

AI algorithms approach the theoretical limit of optical measurement precision

No image is infinitely sharp. For 150 years, it has been known that no matter how ingeniously you build a microscope or a camera, there are always fundamental resolution limits that cannot be exceeded in principle. The position of a particle can never be measured with infinite precision; a certain amount of blurring is unavoidable. This limit does not result from technical weaknesses, but from the physical properties of light and the transmission of information itself.

TU Wien (Vienna), the University of Glasgow and the University of Grenoble therefore posed the question: Where is the absolute limit of precision that is possible with optical methods? And how can this limit be approached as closely as possible?

And indeed, the international team succeeded in specifying a lowest limit for the theoretically achievable precision and in developing AI algorithms for that come very close to this limit after appropriate training. This strategy is now set to be employed in imaging procedures, such as those used in medicine. The study is published in the journal Nature Photonics.

Early camizestrant therapy keeps advanced breast cancer in check

Switching to camizestrant, a next-generation oral SERD, significantly prolongs progression-free survival and maintains quality of life in patients with ESR1-mutated, hormone receptor-positive advanced breast cancer. The proactive, biomarker-guided approach allows earlier intervention and may redefine standard care.

Inside The New Era of Longevity Supplements

More and more people are investing their time and energy into longevity — it’s not just living longer, but living happier, healthier and staying productive well past what has been considered “old age.” McKinsey reports that up to 60 percent of consumers across health and wellness markets say that healthy aging is a “top” or “very important” priority. The movement has created a boost in the health and wellness businesses, and to get an overview of the longevity supplements space, we spoke with Dr. Luke Winegard, the Chief Operating Officer at Longevity Method.

Entrepreneur: What is driving the current boom in the longevity supplement market? Dr. Luke Winegard: Growing consumer demand for health and wellness products is creating explosive growth in the longevity supplement market. Scientific advancements and increasing health consciousness are driving this trend, with consumers now focused on “healthspan” — not just how long they live, but how well they live. The pursuit of longevity has moved from being a niche interest of visionaries to becoming mainstream in 2025.

What does “healthspan” mean and why is it important? Healthspan refers to the period of life spent in good health, free from chronic diseases and disabilities. Today’s consumers are concerned not just about adding years to their lives, but making those years healthy, productive, and vital. This represents a cultural shift toward proactive self-optimization where maintaining energy, cognitive sharpness, and resilience is just as important as achieving physical goals.

Gut bacteria and acetate team up to cut fat in mice without muscle loss

Researchers led by Hiroshi Ohno at the RIKEN Center for Integrative Medical Sciences (IMS) in Japan have discovered a new way to reduce obesity. Their study shows that supplying the gut with extra acetate reduces fat and liver mass in both normal and obese mice, as long as bacteria of the Bacteroides species are also present in the gut.

When both these conditions are met, gut bacteria can eliminate more sugars from the gut and promote the burning of fats for energy in the host. The findings were published in Cell Metabolism.

Affecting hundreds of millions of people around the world, obesity constitutes a global epidemic. It is linked to eating too much sugar and starchy foods and is known to increase the risk of heart disease, type-2 diabetes, and cancer. At the same time, studies show that eating fiber reduces the risk of these very same diseases—even though it cannot be digested directly by mammals.

Scientists Taught People to Change Their Own Brainwaves to Feel Less Pain

The brainwaves of people with neuropathic pain show a distinct pattern: more slow theta waves, fewer alpha waves, and more fast, high beta waves, co-lead author Sylvia Gustin, a clinical psychologist and UNSW professor, said in the statement. Her research has investigated changes in the thalamus—a central brain structure that relays sensory and motor signals to the cerebral cortex—associated with nerve pain.

The PainWaive system consists of an electroencephalogram (EEG) headset that records brain activity paired with an app that instructs patients on how to control their brainwaves through neurofeedback games, according to a UNSW statement. Four participants who suffer from corneal neuropathic pain—a condition that causes painful hypersensitivity of the eyes, face, or head—underwent 20 PainWaive sessions over the course of four weeks.


This study offers new hope for drug-free pain treatments, but further trials will need to verify its results.