A viral video featuring a woman who credits sour sop leaves, apricot seeds, and dietary changes for overcoming stage 4 metastatic breast cancer has ignited widespread discussion on social media.
Originally shared by Super Food Mood on Instagram, the video has amassed significant traction, drawing both support and skepticism.
A Survivor’s Testimony
In this edition, we’ll take a look at a Canadian study which shows that reducing a worm’s ability to fight free radicals in a specific organ could increase it’s lifespan. Does this have any implications for humans?
Contents:
Intro 0:00
Graphical Abstract 1:49
Figure 1. Tissue-specific re-expression of sod-2 rescues deficits in fertility and embryonic lethality in clk-1;sod-2 mutants 2:28
Figure 2. Tissue-specific re-expression of sod-2 can decrease stress resistance in clk-1;sod-2 worms 5:37
Figure 3. Tissue-specific re-expression of sod-2 is not sufficient to reduce clk-1;sod-2 lifespan 6:41
Figure 4. Disruption of mitochondrial superoxide dismutase in the intestine is sufficient to increase lifespan 7:33
Figure 5. Intestine-specific knockdown of sod-2 is sufficient to enhance resistance to heat stress 9:33
Figure 6. Intestine-specific knockdown of sod-2 does not affect physiologic rates 10:29
Conclusion & Next Steps 11:40
Study reviewed:
Intestine-specific disruption of mitochondrial superoxide dismutase extends longevity.
https://www.sciencedirect.com/science/article/pii/S0891584925000383
2009 paper from the same authors:
Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans.
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.
General overview of the pros and cons of free radicals for lifespan:
Introducing a new weekly video series showcasing the latest impactful longevity related studies.
” +Study reviewed: Reducing functionally defective old HSCs alleviates aging-related phenotypes in old recipient mice.
A new weekly series showcasing the latest and most impactful longevity studies.
In this first edition, we’ll take a look at how a subset of blood stem cells from old mice can be used to rejuvenate the blood & immune systems of other old mice and increase their lifespans.
Study reviewed:
Reviewing a trial where young blood plasma was used during joint replacement surgery in older adults, reducing immune system related inflammation and speeding up recovery. This is one of the first human trials of young plasma after many positive results in mice.
Contents:
Intro 0:00
Study Overview 1:07
Proteomic Changes 1:45
Immune Response 3:07
Specific Immune Cell Changes 4:22
Patient Outcomes 6:09
Conclusion 7:44
Study reviewed:
Infusion of young donor plasma components in older patients modifies the immune and inflammatory response to surgical tissue injury: a randomized clinical trial.
https://translational-medicine.biomedcentral.com/articles/10…45;06215-w.
If you liked this video, please consider supporting its creation via a donation to the Canadian Longevity Association, which will not only help create these videos, but also help our other advocacy and outreach efforts:
https://www.zeffy.com/en-CA/donation-form/c47dd699-b5bd-4d28…26f77ddcf3
Or, order something from our new merchandise shop:
Kicking off the first Longevity Review of 2025 with a look at how exosomes can reverse cellular senescence and lengthen lifespan; how there is a subset of youthful stem cells in older animals which can increase lifespan; the most comprehensive study of life extending molescules in the roundworm; and, in the Canadian content study, how disrupting antioxidant defences in a single organ can extend longevity. https://youtu.be/uiEcPFH0EDk
Kicking off the new year with a lifespan special, we will take a look at reversing the senescence of senescent cells to increase mouse lifespan; the discovery and beneficial effects of a subset of youthful stem cells which can also increase mouse longevity; the most comprehensive study of life-extending molecules in the roundworm c.elegans ; and in the Canadian Content study, how disrupting the antioxidant defences in a specific organ in c.elegans can increase its lifespan.
Posted in biotech/medical, genetics, life extension | Leave a Comment on Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial
Longevity Snapshot #5 — Reviewing a trial which shows that a combination of Omega 3, Vitamin D and Exercise slows down biological aging in older adults according to 4 epigenetic clocks.
Applying epigenetic clocks to samples from the DO-HEALTH trial, Bischoff-Ferrari et al. report a small protective effect of omega-3 supplementation over 3 years on several clocks and an additive protective effect of omega-3, vitamin D and exercise using PhenoAge.
Traditional microscopy often relies on labeling samples with dyes, but this process is costly and time-consuming. To overcome these limitations, researchers have developed a computational quantitative phase imaging (QPI) method using chromatic aberration and generative AI.
By leveraging the natural variations in focus distances of different wavelengths, the technique constructs through-focus image stacks from a single exposure. With the help of a specially trained diffusion model, this approach enables high-quality imaging of biological specimens, including real-world clinical samples like red blood cells. The breakthrough could revolutionize diagnostics, providing an accessible and efficient alternative to conventional imaging techniques.
Revealing Insights Without Labels
A stressful life can leave marks on our genetic code, some of which can even be passed on to our children. A study now reveals how the biological impact of trauma on a mother persists long after the violent acts themselves have passed.
The international team of researchers demonstrate the physical mechanisms behind intergenerational trauma in humans, explaining why people with a family history of adversity are more prone to mental health conditions like anxiety and depression, despite not having experienced the adverse events themselves.
The researchers analyzed DNA collected from 48 Syrian families across three generations. These families included grandmothers or mothers who while pregnant had fled the 1982 siege and massacre in Hama or the 2011 armed uprising – both part of the ongoing Syrian civil war.
Cow D lived on a dairy farm in New Zealand. The animal looked like the typical black-and-white cow farmers raise for milk, except for one thing: Researchers had outfitted Cow D with an artificial fistula—a hole offering them a way to reach the microbes inhabiting the animal’s bathtub-size stomach. But it’s what happened next that offers a porthole into the global debate over the use of genetic data.
In the spring of 2009, Samantha Noel, then a doctoral researcher at Massey University in Palmerston North, New Zealand, reached into Cow D’s rumen and plucked out a strain of Lachnospiraceae bacterium, later dubbed ND2006. Another team of geneticists sequenced the microbe’s complete set of genes, or genome, and uploaded the information, which was then shared with GenBank, a public database run by the US National Institutes of Health. If genes are the book of life, then this process was like adding a digital copy to an online library. In policy circles, these lines of code go by another name: digital sequence information, or DSI.
The future of warfare starts in your mind. Understand how Neuroscience, Technology/AI and the OODA loop affects your flow. The world is changing, and cognitive warfare is at the forefront. In our latest podcast episode, we sit down with James Giordano, PhD, a Navy veteran and an expert in neurocognitive science, to delve into the world of cognitive warfare.
Stay in the Loop: https://www.aglx.com/newsletter-signup-north-america.
From the impact of emotions on decision-making to the integration of artificial intelligence and human cognition, this episode challenges your perspective on the battlefield. Join us as we explore the ethical implications of genetic modifications, the transformative effects of psychedelics, and the complexities of data usage in the digital age. Get ready to reimagine the relationship between technology, culture, and language. Don’t miss out on this opportunity to gain valuable insights from our thought-provoking conversation with Dr. Giordano. Tune in now to stay ahead of the curve on the evolving landscape of warfare!
00:00 — Understanding the OODA loop: A Neuroscience Perspective.
09:11 — Exploring Fifth Generation Warfare and Liminal Warfare.
16:06 — The Long Game: China’s Strategic Plan.
22:19 — Understanding Cognitive Warfare and Human-Machine Teaming.
25:52 — The Evolution of Human-Machine Teaming.
29:11 — Human Involvement in AI Decision Making.
36:01 — The Ethics of Paternalistic AI Systems.
40:43 — Technology’s Impact on Cognitive Engagement.
45:13 — Exploring Technologies for Human Performance Enhancement.
55:59 — Diving Into Attacking Mode and Ethics.
56:24 — Hacking the Human Genome.
59:37 — Epigenetic Modification and Phenotypic Shift.
1:04:54 — The Psychedelic Revolution.
1:11:18 — Revisiting Alcohol and Caffeine: Benefits and Burdens.
1:19:18 — Impact of Technology on Cognitive Capacity.
1:23:33 — Information Overload and Burdens.
1:27:02 — Ownership and Security of Personal Data.
1:31:56 — Identifying Predispositional Traits.
1:33:49 — Data Manipulation and Biometrics.
1:40:13 — Cultural Impact of Technology.
1:48:55 — The Role of Education in Integrating Science, Technology, Ethics, and Policy.
1:54:30 — Major Threats and Concerns in Today’s World.
