Lifeboat Foundation

Could discovering how neural stem cells protect themselves from damage lead to treatment that helps combat aging?

We now know that stem cells in the brain do in fact divide, and that this regenerative capacity begins to falter with age. The majority of our cells don’t divide, and the bulk of division falls to stem cell niches dotted across our body. Stem cell populations do age, but they’re more resistant than ‘normal’ cells are, and they produce higher levels of telomerase — enabling them to divide for years.

How do brain stem cells remain free of damage?

Continue reading “How Do Brain Stem Cells Age? Their Damage Filter Breaks Down” »

As implants and bio-hacking gain popularity, could tweaking the body’s circuits become a mainstay in future medicine?

Bioelectronics offer everything from precise diabetes treatment to appetite reduction. In a world where most of us have a phone glued to our hand at all times, combining ‘wetware’ with hardware is starting to make real sense.

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Cortical memory prosthesis uses internal brain signals (e.g., spiketrains) as inputs and outputs, bypassing damaged region (Dong Song et al.)

A brain prosthesis designed to help individuals suffering from memory loss has been developed by researchers at USC and Wake Forest Baptist Medical Center.

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BioViva USA, Inc. has become the first company to treat a person with gene therapy to reverse biological aging, using a combination of two therapies developed and applied outside the United States of America. Testing and research on these therapies is continuing in BioViva’s affiliated labs worldwide.

BioViva CEO Elizabeth Parrish announced Biobthat the subject is doing well and has resumed regular activities. Preliminary results will be evaluated at 5 and 8 months with full outcome expected at 12 months. The patient will then be monitored every year for 8 years.

Gene therapy allows doctors to treat disease at the cellular level by inserting a gene into a patient’s cells instead of using the regular modalities of oral drugs or surgery. BioViva is testing several approaches to age reversal, including using gene therapy to introduce genes into the body.

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Do any existing drugs have longevity promoting effects? Here are 3 currently under investigation.

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Scientists funded by the NIH BRAIN Initiative hope to diagram all of the circuits in the brain. One group will attempt to identify all of the connections among the retina’s ganglion cells (red), which transmit visual information from bipolar cells (green) and photoreceptors (purple) to the brain. (credit: Josh Morgan, Ph. D. and Rachel Wong, Ph. D./University of Washington)

The National Institutes of Health and the Kavli Foundation separately announced today (Oct. 1, 2015) commitments totaling $185 million in new funds supporting the BRAIN Initiative — research aimed at deepening our understanding of the brain and brain-related disorders, such as traumatic brain injuries (TBI), Alzheimer’s disease, and Parkinson’s disease.

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The word on every tech executive’s mouth today is data. Curse or blessing, there’s so much data lying around – with about 2.5 quintillion bytes of data added each day – that it’s become increasingly difficult to make sense of it in a meaningful way. There’s a solution to the big data problem, though: machine learning algorithms that get fed countless variables and spot patterns otherwise oblivious to humans. Researchers have already made use of machine learning to solve challenges in medicine, cosmology and, most recently, crime. Tech giant Hitachi, for instance, developed a machine learning interface reminiscent of Philip K. Dick’s Minority Report that can predict when, where and possibly who might commit a crime before it happens.

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New research from Brown University details a relatively accessible method for making a working (though not thinking) sphere of central nervous system tissue.

If you need a working miniature brain — say for drug testing, to test neural tissue transplants, or to experiment with how stem cells work — a new paper describes how to build one with what the Brown University authors say is relative ease and low expense. The little balls of brain aren’t performing any cogitation, but they produce electrical signals and form their own neural connections — synapses — making them readily producible testbeds for neuroscience research, the authors said.

“We think of this as a way to have a better in vitro [lab] model that can maybe reduce animal use,” said graduate student Molly Boutin, co-lead author of the new paper in the journal Tissue Engineering: Part C. “A lot of the work that’s done right now is in two-dimensional culture, but this is an alternative that is much more relevant to the in vivo [living] scenario.”

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Scientists have created artificial blood vessels that can grow on their own.

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