Lifeboat Foundation

Along with equipment and supplies for the astronauts, the rocket was supposed to deliver several scientific experiments, including one Grattoni and his team spent five years perfecting: a study of how drug-like particles disperse through 100 tiny channels etched in a dime-sized microchip. […] it hit him: the rocket — and his work — was gone. Led by Grattoni, the center has secured coveted approval to conduct several experiments in coming years aboard the $100 billion space station, where scientists can exploit the lack of gravity about 200 miles above the Earth’s surface to perform studies they wouldn’t otherwise be allowed to do on Earth.

Most traditional vaccines have safety and efficacy issues, whereas particulate vaccine delivery systems—which utilize nano- or micro-particulate carriers to protect and deliver antigens—are efficient, stable, include molecules to bolster immune responses, and minimize adverse reactions due to the use of biocompatible biomaterials.

A new review, titled “Particulate delivery systems for vaccination against bioterrorism agents and emerging infectious pathogens,” summarizes the current status of research efforts to develop particulate vaccine delivery systems against bioterrorism agents and emerging infectious pathogens.

How the human brain processes the words we hear and constructs complex concepts is still somewhat of a mystery to the neuroscience community. Transcranial direct current stimulation (tDCS) can alter our language processing, allowing for faster comprehension of meaningful word combinations, according to new research from the department of Neurology the Perelman School of Medicine at the University of Pennsylvania. The work is published in the Journal of Neuroscience.

“Integrating conceptual knowledge is one of the neural functions fundamental to human intelligence,” said the study’s first author Amy Price, a neuroscience graduate student at Penn. “For example, when we read or listen to a sentence, we need to combine, or integrate, the meaning of the words to understand the full idea of the sentence. We perform this process effortlessly on a daily basis but it is quite a complex process and little is known about the brain regions that support this ability.”

Semantic memory is our stored knowledge about the world, such as the meaning of words and objects. “We sought to understand how and in what part of the brain semantic representations are integrated into more complex ideas” said senior author Roy Hamilton, MD, MS, an assistant professor in the departments of Neurology and Physical Medicine & Rehabilitation, and director of the Laboratory for Cognition and Neural Stimulation at Penn. Recent findings from functional MRI scans (fMRI) and magnetoencephalography (MEG) have suggested the angular gyrus, a region of the brain known to be involved in language, number processing and spatial cognition, memory retrieval and attention, as a potential hub for semantic memory integration, specifically the left angular gyrus.

Continue reading “Transcranial direct current stimulation can boost language comprehension: Stimulation of the brain’s left angular gyrus enhanced the comprehension of simple, two-word phrases” »

The blood-brain barrier has stymied direct treatment of brain disorders. In a recently published study, a researcher reports finding a way to pass therapeutics through the barrier, using readily-available agents.

Who needs memory cards when you have DNA? A team of scientists has been able to store images within the life-defining molecules then retrieve them perfectly.

Researchers from the University of Washington have been working out how to take digital files and convert them into strings of DNA that can be easily read back. Luis Ceze, one of the researchers, explains in a press release:

“Life has produced this fantastic molecule called DNA that efficiently stores all kinds of information about your genes and how a living system works — it’s very, very compact and very durable. We’re essentially repurposing it to store digital data — pictures, videos, documents — in a manageable way for hundreds or thousands of years.”

Continue reading “Scientists Stored These Images in DNA—Then Flawlessly Retrieved Them” »

Very cool.

For more than a decade, biomedical researchers have been looking for better ways to deliver cancer-killing medication directly to tumors in the body. Tiny capsules, called nanoparticles, are now being used to transport chemotherapy medicine through the bloodstream, to the doorstep of cancerous tumors. But figuring out the best way for the particles to get past the tumor’s “velvet rope” and enter the tumor is a challenge scientists are still working out. Drexel University researchers believe that the trick to gaining access to the pernicious cellular masses is to give the nanoparticles a new look—and that dressing to impress will be able to get them past the tumor’s biological bouncers.

Targeted cancer therapy is most effective when the medication is released as close as possible to the interior of a tumor, to increase its odds of penetrating and killing off cancerous cells. The challenge that has faced cancer researchers for years is making a delivery vehicle that is sturdy enough to safely get the medication through the bloodstream to tumors—which is no smooth ride—but is also lithe enough to squeeze through the tumor’s dense extra cellular space—a matrix stuffed with sugars called hyaluronic acid.

Continue reading “Dressed to kill: Tailoring a suit for tumor-penetrating cancer meds” »

Nanomedicine has been something that many in tech expected to be a critical part of the healthcare landscape for over a decade. I am glad to see how quickly the technology is being adopted as part of bio-medical research and treatments for various diseases, etc.

NEW YORK, April 7, 2016 /PRNewswire/ — Nano-based science paving the precision medicine era.

The continued development of new treatments associated with the demographic trends and public health considerations is remarkable. Nanotechnology has been identified as one most relevant key enabling technologies of the last ten years, significantly impacting on many different biomedical developments in a broad spectrum of applications therapeutics, diagnostics, theranostics, medical imaging, regenerative medicine, life sciences research and biosciences, among many others. In fact, nanomedicine is present in all therapeutic areas, exhibiting a perceptible and extensive impact in the treatment and diagnosis of some most concerned diseases.

Continue reading “Trends in Nanomedicine — Technology Benchmarking & Innovator Analysis” »

Aluminum gallium nitride UV-C LED devices fabricated with novel epitaxial techniques show improved efficiency and have longer operating lifetimes.

In the pages of comic books and on the silver screen, superheroes like Wolverine and Deadpool have a “healing factor” that allows their bodies to regenerate and recover from injuries or illness at an amazing rate – but certainly nothing like that is possible in real life, right?

Amazingly, a team of scientists led by John Pimanda, a hematologist and associate professor at the University of New South Wales in Australia, published a study in Monday’s edition of the journal PNAS reporting that they had successfully reprogrammed bone and fat cells into induced multipotent stem cells (iMS) – the first step to making such a repair system a reality.

As they explained in a statement, stem cell therapies using iMS cells could theoretically repair a fractured bone or fix injured spinal discs, using a technique similar to how salamanders are able to regenerate lost limbs. These treatments could radically alter the field of regenerative medicine, and perhaps most surprisingly, the authors believe they could be available in just a few years. The technique, which has been successfully tested in mice, “is a significant advance on many of the current unproven stem cell therapies, which have shown little or no objective evidence they contribute directly to new tissue formation,” Pimanda said.

Continue reading “‘Groundbreaking’ Stem Cell Treatment Could Regrow Limbs, Repair Bones” »