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Lyme Disease Vaccine Candidate Reports Study Data

Valneva SE announced final Phase 1 study data and positive initial booster data for its Lyme Disease vaccine candidate VLA15.

“The positive final Phase 1 data for VLA15 supports and validates our plans to continue developing a safe and effective preventative vaccine that can be delivered to those who are at risk of Lyme disease infection,” said Thomas Lingelbach, CEO of Valneva.

“We look forward to continuing the development process with our recently initiated Phase 2 study. We continue to fully commit ourselves to addressing the significant unmet need for a vaccine against Lyme disease.”

Advancing therapy

Despite rapid advances in targeted therapies for cancer, tumors commonly develop resistance to treatment. When resistance emerges, tumor cells continue to grow unchecked, despite all attempts to slow cancer progression. While mutations in cancer cells significantly affect drug sensitivity, it is increasingly recognized that ecological interactions between cells can also play a role.

Jacob Scott, MD, DPhil, a physician-scientist at Cleveland Clinic, is interested in learning how develop and maintain drug resistance from an eco-evolutionary perspective. He studies the evolutionary strategies that cells employ to survive even in the harshest of conditions. One area of focus of his laboratory is to examine the dynamics of sensitive versus and how they affect one another’s growth under the selective pressure of anti-cancer therapies.

“Rather than searching for a ‘silver bullet’ to wipe out all , which is unlikely, we are focused on preventing the resistant cells from taking over—from ‘winning’ every time,” Dr. Scott said. “If we can achieve this goal, we can effectively make cancer a chronic condition.”

Neuromelanin-sensitive MRI identified as a potential biomarker for psychosis

Researchers have shown that a type of magnetic resonance imaging—called neuromelanin-sensitive MRI (NM-MRI)—is a potential biomarker for psychosis. NM-MRI signal was found to be a marker of dopamine function in people with schizophrenia and an indicator of the severity of psychotic symptoms in people with this mental illness. The study, funded by the National Institute of Mental Health (NIMH), part of the National Institutes of Health, appears in the Proceedings of the National Academy of Science.

“Disturbances affecting the are associated with a host of mental and neurological disorders, such as schizophrenia and Parkinson’s disease,” said Joshua A. Gordon, M.D., Ph.D., director of NIMH. “Because of the role dopamine plays in these disorders, the ability to measure dopamine activity is critical for furthering our understanding of these disorders, including how to best diagnose and treat them.”

Neuromelanin is a dark pigment created within dopamine neurons of the midbrain—particularly in the substantia nigra, a brain area that plays a role in reward and movement. Neuromelanin accumulates over the lifespan and is only cleared away from cells following cell death, as occurs in neurodegenerative disorders such as Parkinson’s disease. Researchers have found that NM-MRI signal is lower in the substantia nigra of people with Parkinson’s disease, reflecting the cell death that occurs in these patients.

British woman is first in the world to undergo gene therapy for most common form of blindness

A British woman has become the first person in the world to undergo gene therapy for the most common cause of sight loss.

Surgeons at the John Radcliffe Hospital in Oxford inserted a synthetic gene into the left eye of Janet Osborne, 80, who suffers from age-related macular degeneration (AMD).

Around 600,000 people in the UK are affected by AMD, which affects the central part of a patient’s vision with gaps or ‘smudges’, making everyday activities like reading and recognising faces difficult.

Discovering a New Form of Communication in the Brain

Summary: Researchers have identified a previously unknown form of neural communication. They report the findings could help better the understanding of neural activity associated with specific brain processing and neurological disorders.

Source: Case Western Reserve University.

Biomedical engineering researchers at Case Western Reserve University say they have identified a previously unidentified form of neural communication, a discovery that could help scientists better understand neural activity surrounding specific brain processes and brain disorders.

Liz Parrish : Gene therapy advancements | BioViva | People Unlimited

Liz talking about Rutgers, Integrated Health Systems, anti-aging vaccine(couple of years of gathering data), $75,000 single organ treatment, and potential for very affordable whole body treatment. Q&A at 32 minutes.

Liz Parrish | BioViva, presents at People Unlimited’s Ageless Education, about Gene Therapy Advancements.

The Ageless Education series brings in many of the leading figures in radical life extension to share their views on the most cutting edge strategies for living long enough to live forever.

For more info: http://www.peopleunlimitedinc.com

People Unlimited is an educational, lifestyle and social organization for people interested in living unlimited lifespans.

Continue reading “Liz Parrish : Gene therapy advancements | BioViva | People Unlimited” | >

‘Killer’ cells raise hope of universal flu vaccine

Scientists said Monday they had discovered immune cells that can fight all known flu viruses in what was hailed as an “extraordinary breakthrough” that could lead to a universal, one-shot vaccine against the killer disease.

Influenza epidemics, largely seasonal, kill hundreds of thousands of people each year, according to the World Health Organization.

Due to its mutating strains, vaccine formulas must be regularly updated and only offer limited protection currently.

CRISPR gene editing makes stem cells ‘invisible’ to immune system

UC San Francisco scientists have used the CRISPR-Cas9 gene-editing system to create the first pluripotent stem cells that are functionally “invisible” to the immune system, a feat of biological engineering that, in laboratory studies, prevented rejection of stem cell transplants. Because these “universal” stem cells can be manufactured more efficiently than stem cells tailor-made for each patient—the individualized approach that dominated earlier efforts—they bring the promise of regenerative medicine a step closer to reality.

“Scientists often tout the therapeutic potential of pluripotent stem cells, which can mature into any adult tissue, but the immune system has been a major impediment to safe and effective stem cell therapies,” said Tobias Deuse, MD, the Julien I.E. Hoffman, MD, Endowed Chair in Cardiac Surgery at UCSF and lead author of the new study, published Feb. 18 in the journal Nature Biotechnology.

The immune system is unforgiving. It’s programmed to eradicate anything it perceives as alien, which protects the body against infectious agents and other invaders that could wreak havoc if given free rein. But this also means that transplanted organs, tissues or cells are seen as a potentially dangerous foreign incursion, which invariably provokes a vigorous immune response leading to transplant rejection. When this occurs, donor and recipient are said to be—in medical parlance—” histocompatibility mismatched.”