https://www.youtube.com/watch?v=G6m2tmKlJWQ
A genome sequenced every 15 minutes.
Filmed November 2016.
Continue reading “Craig Venter — How Genome Sequencing Can Fight Aging” »
Epigenetic changes are not all reset with iPS thankfully science has recently demonstrated a technique for reversing that too. The future is looking bright for stem cell quality improvements.
Reprogramming stem cells back to a functionally younger state is not a pefect process and epigenetic changes and mutations remain in place tainting the cells and reducing their quality.
Scientists working in the stem cell field will no doubt be finding ways to work around this and indeed recent work at SALK could reset epigenetic changes in these cells so solutions are within reach in the next few years.
Continue reading “Donor Age Shows Up In Induced Stem Cells” »
In Brief
Motor neurons are vital cells that facilitate muscle contraction and also affect sensation. In diseases like ALS and spinal muscular atrophy, motor cells are plagued with mutations that cause degrees of paralysis and pain in patients. In a study detailed in Cell Stem Cell, scientists developed a mechanism to directly reprogram stem cells into motor neurons.
Cell reprogramming is a novel exploration in medical studies that could treat numerous diseases by growing the body’s own stem cells into healthy cells. The mechanism of reprogramming, however, has just begun to be understood.
The researchers elucidated a new pathway for cell reprogramming by analyzing gene transcription in mice. As established by previous studies, reprogramming is brought about by a series of transcriptions, AKA, how the genes control the expression of other genes.
Continue reading “Reprogramming Stem Cells Could Soon Lead Us to a World Without Paralysis” »
In Brief
A process using human stem cells can generate the cells that cover the external surface of a human heart — epicardium cells — according to a multidisciplinary team of researchers.
“In 2012, we discovered that if we treated human stem cells with chemicals that sequentially activate and inhibit Wnt signaling pathway, they become myocardium muscle cells,” said Xiaojun Lance Lian, assistant professor of biomedical engineering and biology, who is leading the study at Penn State. Myocardium, the middle of the heart’s three layers, is the thick, muscular part that contracts to drive blood through the body.
The Wnt signaling pathway is a group of signal transduction pathways made of proteins that pass signals into a cell using cell-surface receptors.
Continue reading “Stem cells used to regenerate the external layer of a human heart” »
In Brief
Part 2 of the immune system explained in this easy going pop culture style series.
In the penultimate episode of Crash Course Anatomy & Physiology, Hank explains your adaptive immune system. The adaptive immune system’s humoral response guards extracellular terrain against pathogens. Hank also explains B cells, antibodies, and how vaccines work.
Continue reading “Immune System, part 2: Crash Course A&P #46” »
Once again the figures show that young to old disparity in the population is the problem not overpopulation. We really need to develop rejvenation biotechnology with all haste.
Once again overpopulation isnt the problem it is the disparity between young and old in the workforce. This makes rejuvenation biotechnology a suitable solution to avoid economic collapse.
“The world is experiencing unparalleled population aging. This poses problems for productivity and growth, unless we do something about it”
Continue reading “An Aging Population Is Stalling Productivity” »
Researchers from North Carolina State University, the University of North Carolina at Chapel Hill and First Affiliated Hospital of Zhengzhou University have developed a synthetic version of a cardiac stem cell. These synthetic stem cells offer therapeutic benefits comparable to those from natural stem cells and could reduce some of the risks associated with stem cell therapies. Additionally, these cells have better preservation stability and the technology is generalizable to other types of stem cells.
Stem cell therapies work by promoting endogenous repair; that is, they aid damaged tissue in repairing itself by secreting “paracrine factors,” including proteins and genetic materials. While stem cell therapies can be effective, they are also associated with some risks of both tumor growth and immune rejection. Also, the cells themselves are very fragile, requiring careful storage and a multi-step process of typing and characterization before they can be used.
Ke Cheng, associate professor of molecular biomedical sciences at NC State, associate professor in the joint biomedical engineering program at NC State and UNC, and adjunct associate professor at the UNC Eshelman School of Pharmacy, led a team in developing the synthetic version of a cardiac stem cell that could be used in off-the-shelf applications.
