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Senolytic compounds hold promise to reverse aging in humans. Researcher James Kirkland publishes a list of senolytics in a review published yesterday. Two of the senolytics are currently in clinical trials. [Cover photo: Can Senolytic Drugs Reverse Aging? Credit: Getty Images.]

Imagine if you were able to reverse aging and bring your body back to its original health and vigor.

Researchers have already discovered a group of drugs called senolytics which perform this miraculous transformation in mice and are testing them in humans as we speak.

Continue reading “New Senolytic Drugs Reverse Aging — ‘Can Transform Medicine’ Says Leading Researcher” »

UCLA scientists working with middle-aged fruit flies say they were able to improve the insects’ health while markedly slowing down their aging process. The team thinks its technique could eventually help delay the onset of Parkinson’s disease, Alzheimer’s disease, cancer, stroke, cardiovascular disease, and other age-related diseases in humans.

The researchers zeroed in on mitochondria, which often become damaged with age. When cells can’t eliminate the damaged mitochondria, they can become toxic and contribute to a wide range of age-related diseases, said David Walker, Ph.D., a UCLA professor of integrative biology and physiology, and the study’s senior author.

Dr. Walker and his colleagues found that as fruit flies reach middle age—about one month into their two-month lifespan—their mitochondria change from their original small, round shape.

Continue reading “UCLA Team Genetically Manipulates Mitochondria to Extend Fruit Flies’ Lifespan” »

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Why is it that a cut on your finger seems to last for days, but a cut in your mouth is usually healed by morning? There are a lot of factors at play, but 2017 research found one intriguing answer that could benefit more than just your mouth: there’s a molecule in your saliva that can help grow new cells.

Scientists already knew that saliva contains a peptide called histatin-1 that fights off bacteria and aids in wound healing. For a 2017 study published in the FASEB Journal, Chilean researchers set out to discover exactly how the little molecule helped heal wounds. In a series of experiments, they added histatin-1 to chicken embryo cells and several types of human blood-vessel cells, and watched what happened.

Continue reading “Your Saliva Contains a Molecule That Heals Wounds” »

The robots are coming.

Actually, they’re already here. Machines are learning to do tasks they’ve never done before, from locating and retrieving goods from a shelf to driving cars to performing surgery. In manufacturing environments, robots can place an object with millimeter precision over and over, lift hundreds of pounds without getting tired, and repeat the same action constantly for hundreds of hours.

Continue reading “Veo Gives Robots ‘Eyes and a Brain’ So They Can Safely Work With People” »

Research led by The University of Western Australia has discovered a new, simple and less expensive way of growing human stem cells.

Using hydrogel, a gel with a gradient that can be used to mimic the stiffness of human body tissues, the researchers were able to generate positive outcomes for the growth of stem cells.

Dr Yu Suk Choi from UWA’s School of Human Sciences at The University of Western Australia led the international collaboration which also included researchers from the University of California, San Diego (USA) and Max Planck Institute for Medical Research (Germany).

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The secret to a long life? A protein that acts as a cellular ‘time machine’ is found to extend the lifespan of fruit flies by 20%.

Biologists have turned back the clock on ageing in the cells of fruit flies, by increasing levels of a protein called Drp1.

Continue reading “Cellular ‘time machine’ could offer Parkinson’s treatment” »

Oxford scientists are collaborating with artificial Intelligence company Insilico Medicine to prevent unnecessary animal sacrifice and derive more data from experiments in age related research.

The MouseAge.org initiative is being managed by UK charity; Biogerontology Research Foundation and will also include researchers from Harvard and Youth Laboratories in the development of tools for cross-species analysis and novel biomarkers of ageing and various diseases in mice.

Insilico Medicine which provides advanced machine learning services to skin care companies, is using the field of ‘omics’ to introduce a broad range of deep-learned biomarkers of ageing and age-related diseases.

Continue reading “Oxford scientists collaborate with A.I firm on ageing related diseases” »