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With the announcement today that Mammoth Biosciences has received the exclusive license from the University of California, Berkeley to the new CRISPR protein Cas14, the company now has the last piece of its diagnostics toolkit in place.

Cas14 is a newly discovered protein from the lab of Jennifer Doudna, a pioneer in gene-editing research and a member of the first research team to identify and unlock the power of CRISPR technology.

Doudna and Mammoth Biosciences co-founder Lucas Harrington were part of the team of researchers to identify the new Cas14 protein, which can identify single-stranded DNA. The journal Science published their findings in October 2018.

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Image of a group of killer T cells (green and red) surrounding a cancer cell (blue, center) (credit: NIH)

Chinese doctors have reported success with a new type of immunotherapy for multiple myeloma, a blood cancer: 33 out of 35 patients in a clinical trial had clinical remission within two months.

The researchers used a type of T cell called “chimeric antigen receptor (CAR) T.” In a phase I clinical trial in China, the patient’s own T cells were collected, genetically reprogrammed in a lab, and injected back into the patient. The reprogramming involved inserting an artificially designed gene into the T-cell genome, which helped the genetically reprogrammed cells find and destroy cancer cells throughout the body.

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Today, we want to point out a new study suggesting that senescent cells in bone marrow cell populations contribute to the decline of the hematopoietic system, particularly the hematopoietic stem and progenitor cells (HSPCs) that live in the bone marrow and produce our blood cells [1].

The hematopoietic system and immunosenescence

The hematopoietic system is the system of organs and tissues, including the bone marrow, spleen, thymus and lymph nodes, involved in the creation of cellular blood components.

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Egg protein, gelatin etc, ha. I can imagine loads of curling toes among vegetarians vegans and investors alike…ranging from pure horror to utter excitement…yay vegan and gluten free pills… a hole in the market.


The medicines you take contain a soup of active and inactive ingredients.

Active ingredients are the ones that provide a therapeutic benefit, while inactive ingredients are just that — inactive — meaning they don’t react in the body and are instead there to enhance the properties of the medication itself, such as its taste, appearance and ability to be absorbed by the body. [7 Bizarre Drug Side Effects]

But it turns out that inactive ingredients may not be as, well, inactive as we think: A new study finds that, in some patients, inactive ingredients can trigger allergic reactions or other symptoms of food intolerance.

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We’re used to the security risks posed by someone hacking into our computers, tablets, and smartphones, but what about pacemakers and other implanted medical devices? To help prevent possible murder-by-hacker, engineers at Purdue University have come up with a watch-like device that turns the human body into its own network as a way to keep personal technology private.

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We are learning more about fungal infection and neurological diseases. Recently we learned of gingival diseases and Alzheimer’s. My wonder is how plants such as Moringa in one’s diet, that have antifungal properties, can help.


Fungal infections are emerging as a major medical challenge, and a team led by researchers at Baylor College of Medicine has developed a mouse model to study the short-term consequences of fungal infection in the brain.

The researchers report in the journal Nature Communications the unexpected finding that the common yeast Candida albicans, a type of fungus, can cross the blood-brain barrier and trigger an inflammatory response that results in the formation of granuloma-type structures and temporary mild memory impairments in mice. Interestingly, the granulomas share features with plaques found in Alzheimer’s disease, supporting future studies on the long-term neurological consequences of sustained C. albicans infection.

“An increasing number of clinical observations by us and other groups indicates that fungi are becoming a more common cause of upper airway allergic diseases such as asthma, as well as other conditions such as sepsis, a potentially life-threatening disease caused by the body’s response to an infection,” said corresponding author Dr. David B. Corry, professor of medicine-immunology, allergy and rheumatology and Fulbright Endowed Chair in Pathology at Baylor College of Medicine.

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The latest Facebook hack should have shown everyone nothing is safe. Researchers have now shown how easy it is to steal data from people doing research.

Engineers at the University of California say they have demonstrated how easy it would be to snoop on biotech companies making synthetic DNAll you need is an audio recording, they say. Place a smartphone near a DNA synthesizer, record the sound, run the recording across algorithms trained to discern the clicks and buzzes that particular machine makes, and you’ll know exactly what combination of DNA building blocks it is generating.


Researchers devise method for snooping on DNA synthesis using acoustic recordings. But is it a real threat?

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There’s a good chance that in the future, microscopic robots could be swimming and crawling their way through our bodies to deliver drugs or fight infections. While some of these have been capable of manipulating individual cells, researchers at the University of Toronto have developed a new way to get nano-scale probes inside cells, and precisely control them once they’re in there.

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