Lifeboat Foundation

Unlike other ingestible chips, this new version by MIT contains millions of genetically engineered living cells to act as sensors, designed to light up when they detect bleeding.

It’s the latest advance in a growing field of sensors that can be swallowed or worn to monitor our health.

Pills equipped with cameras, thermometers and acidity gauges already look for disease and track digestion.

Continue reading “Swallowable ‘bacteria on a chip’ could help diagnose colon cancer, bowel disorders and gut ulcers” »

You probably thought it was infinitely cool when Ripley and the crew of the Nostromo first emerged from their cryosleep chambers in Alien, but now that slice of sci-fi could become a reality in our lifetime.

NASA and SpaceWorks Enterprises are currently developing a stasis chamber (as opposed to individual pods like those in the movie) that could induce an extended state of torpor, or metabolic inactivity medically brought on by lowering body temperature to the point of mild hypothermia, that could allow astronauts to snooze for at least two weeks on end during longer missions. Also unlike Alien, in which everyone is temporarily in freeze-frame until the ship arrives at its destination, the crew would rotate cryosleep shifts so there is always someone conscious in case something goes awry where no one can here you scream.

SpaceWorks’ objective is to “place crew and passengers in a prolonged hypothermic state during space-mission transit phases (outbound and Earth-return) to significantly reduce the system mass, power, habitable volume, and medical challenges associated with long-duration space exploration,” as explained on their website.

Continue reading “NASA is bringing cryosleep chambers out of fiction and into science” »

Vascular risk and accumulation of beta-amyloids seem to accelerate the rate of cognitive decline in elderly adults.

Vascular risk appears to be a strong predictor of dementia, especially in older individuals with high levels of brain beta-amyloids, and the interaction between these two risk factors might lead to a higher rate of cognitive decline, according to a recent study at the Massachusetts General Hospital.

Alzheimer’s disease (AD) is an age-related neurological disorder whose most feared outcome is dementia, along with other symptoms, such as behavioral issues, loss of motivation, and even the inability to take care of oneself. Patients suffering from AD exhibit an accumulation of plaques in their brains; these plaques, resulting from the build-up of amyloid-beta protein, have long been thought to be the cause of the disease, though other hypotheses have been put forward as well.

Continue reading “Vascular risk appears to accelerate cognitive decline in old age” »

After NAD+ is consumed, it is broken down into nicotinamides and ADP-ribose; the researchers concluded that this means that NAD+ must be resynthesized following this in order for normal cellular functions to continue. This converges with previous studies, which suggest that NAD+ decline leads to changes in metabolism and an increased risk factor for some diseases; this typically happens as the result of aging, as NAD+ levels begin to fall.

With this in mind, the research team thought that cellular metabolism and gene regulation were potentially connected to NAD+ synthesis. They discovered evidence suggesting that compartmentalized NAD+ synthesis and the subsequent consumption are integrated with glucose metabolism and adipogenic transcription as part of the adipocyte differentiation process.

NAD+ synthesis acts as a mediator of PARP-1-regulated transcription during the differentiation of adipocytes, linking cellular metabolism and the adipogenic transcription process. During adipogenesis, nuclear NAD+ levels fall, causing the induction of NMNAT-2, the cytoplasmic NAD+ synthase. This increased level of NMNAT-2 then reduces the availability of NMN and leads to a reduction of nuclear NAD+ synthesis via NMNAT-1. The drop in NAD+ levels then results in decreased PARP-1 activity, which then reduces levels of inhibitory ADP-ribosylation of the adipogenic transcription factor C/EBPβ. Reduced ADP-ribosylation of C/EBPβ means that it is able to bind its target genes, thus promoting the differentiation of preadipocytes into adipocytes. In other words, a decline of NAD+ encourages an increase of preadipocytes turning into adipocyte fat cells.

Despite this, a regular ritual of hype and hysteria is now built into the news cycle. Every now and again, at some huge auditorium, a senior staff member at one of the big firms based in northern California – ordinarily a man – will take the stage dressed in box-fresh casualwear, and inform the gathered multitudes of some hitherto unimagined leap forward, supposedly destined to transform millions of lives. (There will be whoops and gasps in response, and a splurge of media coverage – before, in the wider world, a palpable feeling of anticlimax sets in.)

It’s years since Silicon Valley gave us a game-changer. Instead, from curing disease to colonies on Mars, we’re fed overblown promises, says Guardian columnist John Harris.

Light-sheet fluorescence microscopy could lead to less intrusive and more effective diagnosis for patients.

• By Jonathan Nylk, The Conversation US on May 23, 2018

Erik Gatenholm is Co-Founder and CEO here at CELLINK. In 2017, he founded CELLINK to revolutionize the way that we conduct medical research worldwide. He led a workshop at the C2 Montreal conference called “Need a tissue, Bioprinting is the next Medical Revolution”

At C2 Montreal – There was a presentation on bioprinting and Cellink technology. Then there was an activity where people in groups looked at a sample of bioprinted tissue and people worked on exercises of what people thought was possible or preposterous in the future.

Continue reading “Bioprinting is the next medical revolution — C2 Montreal” »

Today, as part of our series of articles that cover the Hallmarks of Aging, we are going to take a look at the role of proteins in cellular function and how they play a key role in aging.

Proteins are essential for cellular function

Proteins are large, complex molecules that regulate almost everything in your body, either directly or indirectly. They do the majority of the work in cells and are critical for the function, regulation, and structure of tissues and organs.

Continue reading “The Hallmarks of Aging: Loss of Proteostasis” »

Imec, the world-leading research and innovation hub in nano-electronics and digital technologies, presents this week at its technology forum ITF 2018 (Antwerp, May 23–24), a novel organ-on-chip platform for pharmacological studies with unprecedented signal quality. It fuses imec’s high-density multi-electrode array (MEA)-chip with a microfluidic well plate, developed in collaboration with Micronit Microtechnologies, in which cells can be cultured, providing an environment that mimics human physiology. Capable of performing multiple tests in parallel, the new device aims to be a game-changer for the pharmaceutical industry, offering high quality data in the drug development process.

Every year a handful of new drugs make it to the market, but in their wake tens of thousands of candidate drugs didn’t make the cut. Nevertheless, this journey will have taken a decade and costs billions. The fact that drug development is so time-consuming and costly, is because of the insufficiency of the existing methodologies for drug screening assays. These current assays are based on poor cell models that limit the quality of the resulting data, and result in inadequate biological relevance. Additionally, there is a lack of spatial resolution of the assays, resulting in the inability to screen single cells in a cell culture. Imec’s novel organ-on-chip platform aims to address these shortcomings and challenges.

Imec’s solution packs 16,384 electrodes, distributed over 16 wells, and offers multiparametric analysis. Each of the 1,024 electrodes in a well can detect intracellular action potentials, aside from the traditional extracellular signals. Further, imec’s chip is patterned with microstructures to allow for a structured cell growth mimicking a specific organ.

Continue reading “Novel organ-on-chip platform for drug screening” »