Lifeboat Foundation

The Cancer Genome Atlas (TCGA) provides a high-quality resource of molecular data on a large variety of human cancers. Corces et al. used a recently modified assay to profile chromatin accessibility to determine the accessible chromatin landscape in 410 TCGA samples from 23 cancer types (see the Perspective by Taipale). When the data were integrated with other omics data available for the same tumor samples, inherited risk loci for cancer predisposition were revealed, transcription factors and enhancers driving molecular subtypes of cancer with patient survival differences were identified, and noncoding mutations associated with clinical prognosis were discovered.

Science, this issue p. eaav1898; see also p. 401.

With several competing theories, it’s difficult to establish a timeline of how the different blood groups evolved and pinpoint which one came first.

For 50 years, evolutionary theory has emphasized the importance of neutral mutations over adaptive ones in DNA. Real genomic data challenge that assumption.

Government representatives from nearly 170 countries will this month consider whether to temporarily ban the release of organisms carrying gene drives — a controversial technology that can quickly propagate a chosen gene throughout a population. The technique has the potential to eradicate disease, control pests and alter entire ecosystems, but with unpredictable consequences — leading some groups to call for a global moratorium on its field applications.

Research is moving fast on the divisive genetic technology, which could help to eradicate diseases but also risks altering ecosystems in unpredictable ways.

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Michael B. Fossel, M.D., Ph.D. (born 1950, Greenwich, Connecticut) was a professor of clinical medicine at Michigan State University and is the author of several books on aging, who is best known for his views on telomerase therapy as a possible treatment for cellular senescence. Fossel has appeared on many major news programs to discuss aging and has appeared regularly on National Public Radio (NPR). He is also a respected lecturer, author, and the founder and former editor-in-chief of the Journal of Anti-Aging Medicine (now known as Rejuvenation Research).

Prior to earning his M.D. at Stanford Medical School, Fossel earned a joint B.A. (cum laude) and M.A. in psychology at Wesleyan University and a Ph.D. in neurobiology at Stanford University. He is also a graduate of Phillips Exeter Academy. Prior to graduating from medical school in 1981, he was awarded a National Science Foundation fellowship and taught at Stanford University.

In addition to his position at Michigan State University, Fossel has lectured at the National Institute for Health, the Smithsonian Institution, and at various other universities and institutes in various parts of the world. Fossel served on the board of directors for the American Aging Association and was their executive director.

Continue reading “Michael Fossel — Defeating Aging” »

ASHEVILLE, North Carolina — A chickenpox outbreak at a private school now ranks as North Carolina’s largest since a vaccine for the virus became available more than 20 years ago, health officials say.

As of Friday, 36 students at Asheville Waldorf School had contracted the varicella virus, known to most as chickenpox. The school has one of the highest vaccination religious exemption rates in the state.

The viral infection manifests in an itchy rash in most cases and is not typically life-threatening. But the outbreak at Asheville Waldorf should cause concern, said Dr. Jennifer Mullendore of Buncombe County Department of Health and Human Services.

Continue reading “School with major chickenpox outbreak has high vaccination exemption rate” »

A tiny transparent worm could be the key to finding out how to stop the frailty and ill health which often comes with old age.

British scientists are sending tens of thousands of worms into space in a government backed project to see if two drugs can prevent or slow down muscle wasting brought on by microgravity.

In space, the 1mm long c-elegans worms have nothing to push against to maintain their muscle mass and so quickly start losing strength, mirroring the effect experienced by elderly people back on Earth or those with conditions like muscular dystrophy.

Continue reading “How blasting worms into space could help slow down the ageing process” »

From bionic eyes to gene editing, how can we use science to bring back sight?

• By Everyday Einstein Sabrina Stierwalt on November 17, 2018

Taking one or more pills every day can be a hassle, with many people either forgetting or just not bothering. There could soon be an alternative, however. An experimental system that packs a week’s worth of timed-release doses into one capsule has shown promising results in its first clinical study.