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How I cured myself of chronic illness and reversed ageing | Darryl D’Souza | TEDxPanaji

NOTE FROM TED: This talk, which was filmed at a TEDx event, contains several assertions about diet that come from the speaker’s own understanding of nutrition. While some viewers may find advice provided in this talk to be helpful, please do not look to this talk for medical advice. TEDx events are independently organized by volunteers. The guidelines we give TEDx organizers are described in more detail here: http://storage.ted.com/tedx/manuals/tedx_content_guidelines.pdf

Can you cure your self from life threatening health problems? Can you reverse ageing? Darryl D’Souza, an expert in natural therapy and pioneer in integrated wellness and spirituality talks about how he reversed ageing by following simple laws of nature about food and nutrition. How the food that we eat today has become our poison and how we can reclaim our lives and good health. Darryl is the author of “Become Healthy or Extinct”, a book about reversing chronic illnesses with integrated natural therapy. The book has followers in over 150 countries. An engineer by profession, but drawn into the world of natural therapies after failed attempts by modern medicine to cure him of some serious illnesses at a young age. Darryl is a pioneer in Integrated Wellness & Spirituality and conducts life-transforming talks & workshops that expose the real causes of widespread sickness in society and he gives you breakthrough ideas on how to become part of the solution instead of being part of the problem. This talk was given at a TEDx event using the TED conference format but independently organized by a local community.

FDA Calls Psychedelic Psilocybin a ‘Breakthrough Therapy’ for Severe Depression

The FDA is helping to speed up the process of researching and approving psilocybin, a hallucinogenic substance in magic mushrooms, to treat major depressive disorder (MDD).

For the second time in a year, the U.S. Food and Drug Administration (FDA) has designated psilocybin therapy — currently being tested in clinical trials — as “breakthrough therapy,” an action that is meant to accelerate the typically sluggish process of drug development and review. It is typically requested by a drug company and granted only when preliminary evidence suggests the drug may be an enormous improvement over already available therapy, according to the FDA.

Strategy to help cells get rid of disease-related debris

Tohoku University researchers have developed a strategy that could help cells get rid of disease-related debris. Further research could lead to treatments for neurodegenerative and metabolic diseases, Down syndrome, and maybe even aging-related diseases. The findings were published in the journal Molecular Cell.

Cells have a natural ability to routinely rid themselves of unnecessary or dysfunctional proteins and organelles. During this process of “,” debris are tagged with a compound called ubiquitin and then degraded within tiny cellular vacuoles. Autophagy is impaired in some cancers, and neurodegenerative and metabolic diseases, so scientists have been working to develop drugs that can regulate this process. However, little is known about the details of autophagy, such as how the cell knows which components to tag with ubiquitin.

In previous research, Hirokazu Arimoto, a chemical biologist at Tohoku University, and colleagues found that autophagy is initiated against invading streptococci bacteria when they are tagged with the nucleic acid guanine. The researchers wondered if guanine tagging could also initiate autophagy against other cellular components.

Space travel can make the gut leaky

Bacteria, fungi, and viruses can enter our gut through the food we eat. Fortunately, the epithelial cells that line our intestines serve as a robust barrier to prevent these microorganisms from invading the rest of our bodies.

A research team led by a biomedical scientist at the University of California, Riverside, has found that simulated microgravity, such as that encountered in spaceflight, disrupts the functioning of the epithelial barrier even after removal from the .

“Our findings have implications for our understanding of the effects of space travel on intestinal function of astronauts in space, as well as their capability to withstand the effects of agents that compromise intestinal epithelial barrier function following their return to Earth,” said Declan McCole, a professor of biomedical sciences at the UC Riverside School of Medicine, who led the study published today in Scientific Reports.

Stem cell therapy helps broken hearts heal in unexpected way

Stem cell therapy helps hearts recover from a heart attack, although not for the biological reasons originally proposed two decades ago that today are the basis of ongoing clinical trials. This is the conclusion of a Nov. 27 study in Nature that shows an entirely different way that heart stem cells help the injured heart—not by replacing damaged or dead heart cells as initially proposed.

The study reports that injecting living or even dead heart stem cells into the injured hearts of mice triggers an acute inflammatory process, which in turn generates a wound healing-like response to enhance the mechanical properties of the injured area.

Mediated by macrophage cells of the immune system, the secondary healing process provided a modest benefit to heart function after , according to Jeffery Molkentin, Ph.D., principal investigator, director of Molecular Cardiovascular Microbiology a Cincinnati Children’s Hospital Medical Center and a professor of the Howard Hughes Medical Institute (HHMI).

The world’s been waiting for male birth control. India may be the first to launch it

But however promising RISUG may seem, and however much the world needs a new form of male birth control, some researchers are skeptical. And a closer look at the most recent phase three clinical trial of the treatment in India suggests there’s good reason to be cautious.

Sharma recently published the results of the clinical trial on RISUG in the Indian Journal of Medical Research, and it tells a slightly more complicated story than what he’s been telling the press. The study involved 139 men under the age of 41 who were living with their wives and had at least two children each. The men were given a single dose of RISUG and then followed up by doctors for six months. Their wives were also monitored to find out if they became pregnant. Note: This is a small, short-term study.

Importantly, the partners of the 133 men in the trial who got the shot didn’t get pregnant despite having unprotected sex.

Cyborg Soldier 2050: Human/Machine Fusion and the Implications for the Future of the DOD

[Editor’s Note: Mad Science Laboratory is pleased to excerpt below the Executive Summary from a DoD Biotechnologies for Health and Human Performance Council (BHPC) study group report entitled, Cyborg Soldier 2050: Human/Machine Fusion and the Implications for the Future of the DOD. This report, authored by Peter Emanuel, Scott Walper, Diane DiEuliis, Natalie Klein, James B. Petro, and James Giordano (proclaimed Mad Scientist); and published by the U.S. Army Combat Capabilities Development Command Chemical Biological Center (CCDC CBC), culminates a year-long assessment to forecast and evaluate the military implications of machines that are physically integrated with the human body to augment and enhance human performance over the next 30 years. This report summarizes this assessment and findings; identifies four potential military-use cases for new technologies in this area; and makes seven recommendations on how the U.S. should proceed regarding human/machine enhancement technologies. Enjoy!]

A DoD BHPC study group surveyed a wide range of current and emerging technologies relevant to assisting and augmenting human performance in many domains. The team used this information to develop a series of vignettes as case studies for discussion and analysis including feasibility; military application; and ethical, legal, and social implication (ELSI) considerations.

Ultimately, the team selected four vignettes as being technically feasible by 2050 or earlier. The following vignettes are relevant to military needs and offer capabilities beyond current military systems:

Japan and Singapore Grant CRISPR Patents to Merck

Merck now holds 22 CRISPR-related patents worldwide across nine different geographies.

- Patents cover Paired Cas9 Nickase CRISPR genome-editing technology to advance gene therapy and research.

DARMSTADT, Germany, Nov. 26, 2019 /PRNewswire/ — Merck, a leading science and technology company, today announced that the Japan Patent Office and the Intellectual Property Office of Singapore have each allowed the company’s patent application for the use of paired CRISPR nickases, bringing Merck’s number of patents to 22 worldwide.

The Psychology of Beating an Incurable Illness | Bob Cafaro | TEDxCharlottesville

NOTE FROM TED: Please do not look to this talk for medical advice. This talk, which was filmed at a TEDx event, contains strong assertions about multiple sclerosis and lifestyle medicine that lack sufficient scientific evidence for general prescription. TEDx events are independently organized by volunteers. The guidelines we give TEDx organizers are described in more detail here: http://storage.ted.com/tedx/manuals/tedx_content_guidelines.pdf

After a shocking diagnosis that would begin stripping Bob Cafaro of his ability to perform, sheer willpower and changes to his daily life allow him to beat all odds.

Bob Cafaro played chamber music full time and served on the faculty of the University of Virginia until 1983 when he became a regular with the Metropolitan Opera Orchestra. He later joined the Baltimore Symphony and in 1985 became a member of the Philadelphia Orchestra. In 1999, Bob was stricken with a virulent case of Multiple Sclerosis, which left him nearly blind and without the use of his hands. Defying what doctors had told him, he made a complete and remarkable recovery and has since written a book, been a member of The Rachmaninov Trio since 2003, and has grown passionate in his involvement with volunteer and outreach activities.

This talk was given at a TEDx event using the TED conference format but independently organized by a local community.