Lifeboat Foundation

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Frozen corpses could be brought back to life and made to look YOUNGER than when they died using stem cell injections, claims expert…

EXCLUSIVE: Dennis Kowalski, President of the Michigan-based Cryonics Institute, has claimed scientists could revive a frozen human corpse by using stem cells to help repair damaged cells.

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On the run up to Undoing Aging 2018, Nicola Bagalà from LEAF did an interview to learn a bit more about our foundation and the story of our involvement in life extension.

As our readers probably already know, from March 15 to March 17 this year, the Undoing Aging 2018 Conference will be held at the Umspannwerk Alexanderplatz in Berlin, Germany. The event is intended to bring together scientists working on repair-based therapies for aging as well as to give life sciences students—and anyone else who may be interested, really—an occasion to deepen their understanding of the current state of rejuvenation research.

Organised by the Forever Healthy Foundation and the SENS Research Foundation, the conference will feature eminent researchers among its many speakers, such as the director of the Wake Forest Institute for Regenerative Medicine, Dr. Anthony Atala; Dr. Kristen Fortney, who is an expert on computational drug discovery and aging biomarkers; Dr. Michael West, co-CEO of BioTime and founder of Geron Corporation; Dr. James Kirkland, a world-class expert on cellular senescence; and Dr. Vera Gorbunova, a pioneer of the comparative biology approach to the study of aging and co-director of the Rochester Aging Research Center. In addition to its scientific, educational, and networking value, UA2018 will no doubt greatly contribute to the popularisation of this area of research and help spread awareness, both about the problem represented by age-related diseases and the great opportunity we have to finally bring aging under comprehensive medical control within a relatively short time frame.

Continue reading “Undoing Aging With Michael Greve” »

The Pentagon is hoping to tap into the incredible survival techniques of some of nature’s hardiest creatures to ‘slow biological time’ on the battlefield.

DARPA’s new program, dubbed Biostasis, aims to develop ways to buy extra time for wounded soldiers between the moment of injury and first medical treatment.

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A research team composed of scientists from the Institute of Bioengineering and Nanotechnology (IBN) of the Agency for Science, Technology and Research (A*STAR) and IBM Research has produced a new synthetic molecule that can target and kill five multidrug-resistant bacteria. This synthetic polymer was found to be non-toxic and could enable entirely new classes of therapeutics to address the growing problem of antibiotic-resistant superbugs.

The synthetic molecules are called guanidinium-functionalized polycarbonates and were found to be both biodegradable and non-toxic to human cells. Essentially, the positively-charged synthetic polymer enters a living body and binds specifically to certain bacteria cells by homing in on a microbial membrane’s related negative charge. Once attached to the bacteria, the polymer crosses the cell membrane and triggers the solidification of proteins and DNA in the cell, killing the bacteria.

Eye-drops that can repair the corneas and can improve the short and long sightedness have been developed by a team of Ophthalmologists at Shaare Zedek Medical Center and Bar-Ilan University’s Institute of Nanotechnology and Advanced Materials. The solution of nanoparticles called the ‘nanodrops’ was successfully tested on a pig’s cornea. Clinical trials are expected to be carried out later this year. If the clinical trials on humans are successful, it is expected that the need of eyeglasses will be eliminated.

The leader of the research team, Dr. David Smadja, said that the eye-drops can bring a revolution in ophthalmological and optometry treatment of patients who are suffering from myopia, hyperopia and other refractory conditions. The revolutionary breakthrough in the field was revealed by Dr. Smadja at Shaare Zedek’s second biennial research day, which was held at Steinberg Auditorium in Jerusalem. He said that the nano drops can also be used to replace multifocal lenses and allow people to see objects from different distances. Smadja said, “This is a new concept for correcting refractory problems.” However, he didn’t mention the times of applications which will replace the need for the glasses completely.

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Battlefield medics frequently only have a brief window of opportunity to treat an injury before it’s fatal or causes permanent disabilities, and it’s frequently so fleeting that there’s not much they can do. DARPA is exploring an unusual solution to that problem: slow the biological processes to give medics more room to breathe. Its new Biostasis research program aims to bring cell activity to a near halt by using biochemicals that control energetics at the protein level. If animals like tardigrades and wood frogs can stabilize their cells to survive freezing and dehydration, similar techniques might offer more time to medics who want to treat wounds before a victim’s vital systems break down.

DARPA knows this won’t be easy. The trick is to slow down every cellular process at roughly the same rate — you can’t just pause a few while others run at full speed. You’d also have to minimize any damage when the cells return to their normal function.

The Biostasis program is still very young (its first day for answering proposers’ questions is March 20th), and DARPA isn’t expecting too much even from complete projects: it’s initially focusing on “benchtop” proofs of concept and will focus on real-world uses as the program nears its 5-year end. If it has any success, though, the program could prove to be a breakthrough for the medical field as a whole, not just in combat. Paramedics could buy themselves enough time to get a patient to hospital, and doctors could focus less on basic survival and more on full recoveries.

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An international group of researchers has made a decisive step towards creating the technology to achieve simulations of brain-scale networks on future supercomputers of the exascale class. The breakthrough, published in Frontiers in Neuroinformatics, allows larger parts of the human brain to be represented, using the same amount of computer memory. Simultaneously, the new algorithm significantly speeds up brain simulations on existing supercomputers.

The human brain is an organ of incredible complexity, composed of 100 billion interconnected nerve cells. However, even with the help of the most powerful supercomputers available, it is currently impossible to simulate the exchange of neuronal signals in networks of this size.

“Since 2014, our software can simulate about one percent of the neurons in the human brain with all their connections,” says Markus Diesmann, Director at the Jülich Institute of Neuroscience and Medicine (INM-6). In order to achieve this impressive feat, the software requires the entire main memory of petascale supercomputers, such as the K computer in Kobe and JUQUEEN in Jülich.

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When this DNA origami nanorobot detects blood vessels associated with tumors, it opens up to deliver thrombin, a clotting factor that chokes off the blood supply to the tumor.