Lifeboat Foundation

The ocean’s creatures hold secrets to some of today’s biggest medical mysteries.

“I believe gene therapy will become a mainstay in treating, and maybe curing, many of our most devastating and intractable illnesses,” said FDA commissioner Dr Scott Gottlieb after Luxturna’s approval.

As innovative gene and cell therapies continue to make the transition from the laboratory to the clinic, they are bringing with them the promise of truly personalised medicine. The last few years have seen the regulatory approval of the first gene therapies that take a patient’s own immune cells and genetically engineer them to target cancer cells more effectively.

These chimeric antigen receptor T-cell (CAR-T) therapies now represent a rapidly growing field, with Novartis’s Kymriah, the first CAR-T therapy approved by the US Food and Drug Administration (FDA) in August 2017 for the treatment of a rare blood cancer, seen as the tip of the iceberg for this treatment class’ potential. Approval of Kite Pharma’s Yescarta, a CAR-T treatment for certain forms of non-Hodgkin lymphoma, followed just a few months later.

Continue reading “Can the gene and cell therapy revolution scale up?” »

Scientists have designed a special type of drug that helps the body eat and destroy cancerous cells.

The treatment boosts the action of white blood cells, called macrophages, that the immune system uses to gobble up unwanted invaders.

Tests in mice showed the therapy worked for aggressive breast and skin tumours, Nature Biomedical Engineering journal reports.

The next phase of a NASA sponsored mission to 3D print human organs and tissues in space will launch in February 2019. A 3D BioFabrication Facility (BFF) developed by nScrypt and Techshot and destined for the International Space Station (ISS) will form part of the cargo of SpaceX CRS-17.

3D printing in zero gravity

Continue reading “SpaceX mission will bring 3D bioprinter to ISS, plans to 3D print cardiac patches for damaged hearts” »

Monsanto’s agricultural biotechnology research and development operations that are going to Bayer are the largest in the world and include making genetically modified seeds for such crops as corn, soybeans and cotton. Corn represented almost 60 percent of Monsanto’s total seed and genomics business last year.

German conglomerate Bayer on Thursday closed its $63 billion merger with St. Louis-based agribusiness giant Monsanto and plans to drop the U.S. company’s name.

(HealthDay)—Get up off of the couch: Sitting too much may kill you even if you exercise regularly.

If you sit for six hours a day or more, your risk of dying early jumps 19 percent, compared with people who sit fewer than three hours, an American Cancer Society study suggests.

And, the study authors added, sitting may kill you in 14 ways, including: cancer; heart disease; stroke; diabetes; kidney disease; suicide; chronic obstructive pulmonary disease (COPD); lung disease; liver disease; peptic ulcer and other digestive disease; Parkinson’s disease; Alzheimer’s disease; nervous disorders; and musculoskeletal disorders.

Researchers have created a new molecule — IMP-1088 — that can render the human body inhospitable for certain viruses. The tests carried out show it can block several strains of rhinovirus, which is the main cause of the common cold.

Researchers at the University of Alabama at Birmingham have shown—for the first time—that established lung fibrosis can be reversed using a drug treatment that targets cell metabolism.

This novel finding, reported in the journal Nature Medicine, is important because, despite significant advances to reveal the pathological mechanisms of persistent fibrosis, effective treatment interventions are lacking.

Pulmonary fibrosis can develop after lung injuries like infections, radiation or chemotherapy, or it can have an unknown cause, as in idiopathic pulmonary fibrosis, or IPF is a progressive, and ultimately fatal, lung disorder that strikes more than 150,000 patients a year in the United States and more than 5 million worldwide.

Continue reading “Metformin reverses established lung fibrosis” »

Senolytics have been in the news a great deal ever since van Deursen and his team conducted a landmark 2011 study showing that removing senescent cells could delay age-related ill health in mice [1]. Since then, interest in what was once a niche topic has continued to grow at an ever-increasing pace. Now, there are many researchers engaged in exploring senescent cells and their role in aging and disease.

Lately, there has been enthusiastic interest in developing therapies to remove these problematic senescent cells, but are there potentially better ways to deal with senescent cells beyond periodically purging them with senolytic drugs and therapies?