Lifeboat Foundation

Some of Allen’s philanthropy has taken a scientific bent: Allen founded the Allen Institute for Brain Science in 2003, pouring $500 million into the non-profit that aims to give scientists the tools and data they need to probe how brain works. One recent project, the Allen Brain Observatory, provides an open-access “catalogue of activity in the mouse’s brain,” Saskia de Vries, senior scientist on the project, said in a video. That kind of data is key to piecing together how the brain processes information.

Microsoft co-founder Paul Allen died today from complications with non-Hodgkin’s lymphoma. He was 65. Allen said earlier this month that he was being treated for the disease.

Allen was a childhood friend of Bill Gates, and together, the two started Microsoft in 1975. He left the company in 1983 while being treated for Hodgkin’s lymphoma and remained a board member with the company through 2000. He was first treated for non-Hodgkin’s lymphoma in 2009, before seeing it go into remission.

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The cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells, and in most of the cases develop into malignant masses of tissues called tumors, and it is the leading causes of mortality and a major public health challenge worldwide. In normal body, genes in the cell nucleus, containing long strings of DNA (deoxyribonucleic acid) regulate the controlled division and function of cells and any damage to DNA causes the mutation of genes, which in turn triggers the uncontrolled division of abnormal cells, leading to the damage of vital organs. Cancer cells can detach from the original mass of tumor and migrate to new locations through blood and lymphatic system and also cancer cells produce enzymes that are capable of breaking the normal cells. For cancer diagnostics, the conventional histopathological and radiological examinations are still used for evaluating the clinical and pathologic staging, needed for cancer treatments. Depends on the stage of cancer development, different treatment options like chemotherapy, radiation therapy, stem cell transplant, immunotherapy, hormone therapy, targeted drug therapy and surgery are advised. The major disadvantages of the available advanced treatment options include non localized invasion to other body parts, intolerable cytotoxicity, unsystematic distribution of antitumor agents, immune to chemical agents, low bioavailability and limited option to evaluate the tumor cell response to therapies^4,5. In spite of the drawbacks of these advanced treatment options, cancer is curable if it is diagnosed at an early stage.

Phototherapy has been used for the treatment of jaundice, cancer, dermatological conditions, and ophthalmological disorders by simply using the light of certain selected wavelength. Photodynamic therapy, on the other hand is a method of photosensitizing the action of drugs to kill cancer cells, but the major drawback of this treatment is that most of the drugs used for photodynamic therapy remain activated for a long time, leading to overdose to damage non cancer cells. In the photo-catalytic process, no drug is used, instead the nontoxic semiconductor photo-catalyst like WO₃ generates electron hole pairs, when it is exposed to the light of appropriate wavelength and these photo-generated charge carriers mediate oxidation and reduction reactions in the cancer cell to eliminate them.

New research, led by scientists at the University of Cambridge, suggests spontaneous DNA mutations that occur when a baby’s brain is growing in the womb may help explain why so many people develop dementia without having any prior family history with the disease.

A new treatment strategy could increase the success rate of stem cell transplants, according to University of Queensland researchers.

The approach removes the need for donor matching and the use of immunosuppressant drugs to prevent rejection, and could make stem cell treatment accessible to more patients.

UQ Diamantina Institute researcher Dr Jatin Patel said researchers found immunosuppressant drugs had a negative impact on the transplanted stem cells.

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Should there be any ethical or legal boundaries to technologies that enhance humans? I pondered this last week as I read an online article about the recent trials of upper-body “exoskeletons” by production line staff at Volkswagen and at Chrysler-Fiat. These lightweight wearable frames greatly reduce the physical strain of repetitive overhead assembly work, and will be an important industrial enhancement as workforces age.

We tend to think of medical advancement in terms of better cures for diseases and recovery from injury. Enhancement however goes beyond therapy, and extends us in ways that some may argue are unnatural. Some human enhancements are of course also pre-emptive therapeutic interventions. Vaccination is both an enhancement of our immune system, and a therapeutic intervention. However, in cases where there is little preventative justification, what degree of enhancement is acceptable?

We drink coffee expecting our work performance to improve. We accept non-elective operations, breast implants, orthodontic improvements and other interventions which improve our perception of ourselves. We generally accept such enhancements with little question. However devices and drugs that improve athletic performance can lead us to question their legitimacy.

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Intervene Immune is a company focused on the age-related decline of the immune system, which is known as immunosenescence. Here, Bobby Brooke, CEO of Intervene Immune, discusses the clinical potential of regenerating the thymus as a means of reversing age-related immune system decline.

Earlier this year, we hosted the Ending Age-Related Diseases 2018 conference at the Cooper Union, New York City. This was a conference designed to bring together the best in the aging research and biotech investment worlds and saw a range of industry experts sharing their insights.

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To understand the mechanisms by which molecules act in cells, or the effects of drugs on them, it would be ideal to be able to track individual molecules, including where in the cell they are located and what modifications they undergo when conditions in the cell change. However, this has proven difficult with existing technologies, particularly given the amount of time required to perform such monitoring.

A research team centered at Osaka University, in collaboration with RIKEN, has developed a system that can overcome these difficulties by automatically searching for, focusing on, imaging, and tracking single molecules within living cells. The team showed that this approach could analyze hundreds of thousands of single molecules in hundreds of cells in a short period, providing reliable data on the status and dynamics of molecules of interest.

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Anversa, who according to publications was most recently affiliated with the Cardiocentro Ticino and University of Zurich, could not be reached for comment. An email to his address at Cardiocentro Ticino bounced back. A number of Anversa’s co-authors either did not immediately respond to a request for comment, or declined.

“We are committed to upholding the highest ethical standards and to rigorously maintaining the integrity of our research,” Harvard and the Brigham said. “Any concerns brought to our attention are reviewed in accordance with institutional policies and applicable regulations.”

Anversa received his MD from the University of Parma in Italy and gained prominence as a stem-cell researcher at New York Medical College in Valhalla, N.Y., where he worked before moving to Harvard Medical School and the Brigham in 2007. Anversa became a full professor in 2010, joined in that rank that year by Dr. José Baselga, who earlier this fall resigned his post at Memorial Sloan Kettering Cancer Center amid reports that he failed to adequately disclose financial conflicts of interest.

Continue reading “Harvard and the Brigham call for 31 retractions of cardiac stem cell research” »

Shanghai Gensource Medical Appliances, will distribute Tel Aviv based Micromedic’s product to the group’s customers in 25 cities across China and more than 8,000 hospitals and medical centers.