Archive for the ‘biotech/medical’ category: Page 2

Jun 15, 2024

Biotech companies are trying to make milk without cows

Posted by in categories: biotech/medical, food

The bird flu crisis on dairy farms could boost interest in milk protein manufactured in microorganisms and plants.

Jun 14, 2024

New DNA sequencing technique detects early genetic mutations

Posted by in categories: biotech/medical, genetics

HiDEF-seq advances cancer treatment:

HiDEF-seq technique could further help develop or advance new prevention approaches or develop treatments for genetic diseases and even cancer.

Continue reading “New DNA sequencing technique detects early genetic mutations” »

Jun 14, 2024

New study offers clues into genetics of X chromosome loss

Posted by in categories: biotech/medical, genetics, life extension

The DNA a woman is born with may influence how her cells respond to chromosomal abnormalities acquired with aging, according to a new genomic analysis co-led by NCI researchers.

Jun 14, 2024

BRAF-Targeted Drug Approved for Pediatric Low-Grade Glioma

Posted by in category: biotech/medical

FDA has granted an accelerated approval to tovorafenib (Ojemda) for kids and teens who have low-grade glioma with changes in the BRAF gene.

Jun 14, 2024

Immunotherapy to treat cancer gave rise to 2nd cancer in extremely rare case

Posted by in category: biotech/medical

Although very rare, past reports show some cancer patients may develop secondary cancers following lifesaving CAR T-cell therapy.

Jun 14, 2024

Generation of ‘semi-guided’ cortical organoids with complex neural oscillations

Posted by in categories: biotech/medical, neuroscience

This protocol details the generation of cortical organoids with complex neural oscillations through a ‘semi-guided’ protocol, and their functional characterization using microelectrode array measurements, calcium imaging and adeno-associated virus transduction.

Jun 14, 2024

Why many lung cancer patients who have never smoked have worse outcomes

Posted by in categories: biotech/medical, genetics

The reason targeted treatment for non-small cell lung cancer fails to work for some patients, particularly those who have never smoked, has been discovered by researchers from UCL, the Francis Crick Institute and AstraZeneca.

The study, published in Nature Communications, shows that lung cancer cells with two particular genetic mutations are more likely to double their genome, which helps them to withstand treatment and develop resistance to it.

In the UK, lung cancer is the third most common type of cancer and the leading cause of cancer death. Around 85% of patients with lung cancer have (NSCLC), and this is the most common type found in patients who have never smoked. Considered separately, “never smoked” lung cancer is the fifth-most common cause of cancer death in the world.

Jun 14, 2024

Study Offers New Detail on how COVID-19 Affects the Lungs

Posted by in category: biotech/medical

New research shows that ferroptosis, a form of cell death, occurs in severe COVID-19 patient lungs. Stopping it improves outcomes. In some severe cases of COVID-19, the lungs undergo extreme damage, resulting in a range of life-threatening conditions like pneumonia, inflammation, and acute respiratory distress syndrome. The root cause of those wide-ranging reactions in the lungs has until now remained unclear.

A new study by researchers at Columbia and the Columbia University Irving Medical Center sheds light on this mystery.

The study found that ferroptosis, a form of cell death first named and identified at Columbia in 2012, is the major cell death mechanism that underlies COVID-19 lung disease.

Jun 13, 2024

Biomedicine Breakthrough: Complete Gene Insertion Now Possible in Human Cells

Posted by in categories: biotech/medical, genetics

The gene-editing technique employs prime editors along with advanced enzymes known as recombinases. This method has the potential to lead to universal gene therapies that are effective for conditions like cystic fibrosis.

Researchers at the Broad Institute of MIT and Harvard have enhanced a gene-editing technology that can now efficiently insert or replace entire genes in human cell genomes, potentially making it suitable for therapeutic uses.

The advance, from the lab of Broad core institute member David Liu, could one day help researchers develop a single gene therapy for diseases such as cystic fibrosis that are caused by one of hundreds or thousands of different mutations in a gene. Using this new approach, they would insert a healthy copy of the gene at its native location in the genome, rather than having to create a different gene therapy to correct each mutation using other gene-editing approaches that make smaller edits.

Jun 13, 2024

Aging and cancer

Posted by in categories: biotech/medical, life extension

Exhibit apparent links that we will examine in this review. The null hypothesis that aging and cancer coincide because both are driven by time, irrespective of the precise causes, can be confronted with the idea that aging and cancer share common mechanistic grounds that are referred to as ‘hallmarks’. Indeed, several hallmarks of aging also contribute to carcinogenesis and tumor progression, but some of the molecular and cellular characteristics of aging may also reduce the probability of developing lethal cancer, perhaps explaining why very old age ( 90 years) is accompanied by a reduced incidence of neoplastic diseases. We will also discuss the possibility that the aging process itself causes cancer, meaning that the time-dependent degradation of cellular and supracellular functions that accompanies aging produces cancer as a byproduct or ‘age-associated disease’

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