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Category: biotech/medical – Page 1,934

Prisoners Are Using Smuggled Cellphones to Show the Coronavirus Nightmare Behind Bars

The coronavirus has killed dozens of federal prisons and infected more than 6,000. Prisoners say they have been stuck in grim conditions that make social distancing impossible. To support their claims, some prisoners have used contraband cell phones that have been smuggled into prisons to post videos on Facebook and other social media sites.

VICE News contacted one of the prisoners, 34-year-old Aaron Campbell, held at a federal prison in Ohio, who said he was punished for making his video by being sent to solitary confinement. In a letter, Campbell said officials told him he would not face additional discipline if he issued a statement saying the video was fake. He refused. (The BOP did not respond to questions about his allegations.)

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Netflix ‘Pandemic’ Star Just Showed His Covid-19 Antibody Drug Works In Hamsters. How Quickly Could It Treat Humans?

Via Jacob Gunn Glanville

Here’s the Forbes article on our program. Press release and some media to follow. We will be publishing our manuscript within a week to bioarxiv.

Jacob Glanville is an admirer of the human immune system — but he thinks we can do better.

On Tuesday, his company Centivax announced that they have created optimized antibodies that protect hamsters from lethal amounts of the virus that causes COVID-19. Compared to animals that did not receive the antibody, treated hamsters were found to have 97 percent less virus in their lungs after 48 hours.

This is a milestone for Centivax, which is among many companies trying to develop antibody treatments for COVID-19. Centivax’s antibodies are unique, however, in how they are made. Rather than using mammalian cells to produce a protein drug, which is common, slow, and expensive, Centivax is using cheap bacteria.

These Tiny Neutron Generators Could Pave the Way for Fusion

The Madison, Wisconsin-based startup Phoenix has scouted a team of nuclear elites for a new frontier: small reactors that can revolutionize medical imaging, munitions scanning, and even non-destructive testing for quality assurance.

And in the longer term, scientists say training people to run neutron generators helps to familiarize and speed up the future of nuclear fusion.

CAR T cells beyond cancer: Targeting senescence-related diseases

Chimeric antigen receptor (CAR) T cells have transformed the treatment of refractory blood cancers. These genetically engineered immune cells seek out and destroy cancer cells with precision. Now, scientists at Memorial Sloan Kettering are deploying them against other diseases, including those caused by senescence, a chronic “alarm state” in tissues. The scope of such ailments is vast and includes debilitating conditions, such as fibrotic liver disease, atherosclerosis, and diabetes.

Key to the success of CAR T cell therapy has been finding a good target. The first US Food and Drug Administration-approved CAR T cells target a molecule on the surface of blood cancers called CD19. It is present on but few other , so side effects are limited.

Taking their cue from this prior work, a team of investigators including Scott Lowe, Chair of the Cancer Biology and Genetics Program in the Sloan Kettering Institute, and Michel Sadelain, Director of the Center for Cell Engineering at MSK, along with their trainees Corina Amor, Judith Feucht, and Josef Leibold, sought to identify a target on senescent cells. These cells no longer divide, but they actively send “help me” signals to the immune system.

Regeneron Launches Trials of COVID-19 Antibody “Cocktail”

The cocktail, now named REGN-COV2, consists of two antibodies—REGN10933 and REGN10987—that are designed to bind non-competitively to the receptor binding domain of SARS-CoV-2’s spike protein. Regeneron says that such binding diminishes the ability of mutant viruses to escape treatment—with details from preclinical research to be published in upcoming research studies.

Regeneron Pharmaceuticals said today it has launched the first clinical trial of its dual-antibody “cocktail” designed to both prevent and treat COVID-19, as well as prevent viral escape. The cocktail, now named REGN-COV2, consists of two antibodies—REGN10933 and REGN10987—that are designed to bind non-competitively to the receptor binding domain of SARS-CoV-2’s spike protein. [Regeneron].

Israeli AI firm that offers early COVID-19 detection gets FDA approval

CLEW, an Israeli medtech firm specializing in real-time AI analytics platforms, received approval from the United States Food and Drug Administration (FDA) for its “Predictive Analytics Platform in Support of COVID-19 Patients,” the company announced Tuesday.

The Intensive Care Unit (ICU) solution was given Emergency Use Authorization (EUA) by the FDA so that it may be implemented within the United States’ health system as soon as possible.

Coronavirus: Nitric Oxide Eyed as a Possible COVID-19 Cure and Answer to Ventilator Shortages

The search for viable coronavirus infection treatments is still ongoing. Many doctors are taking a second look at as many different existing drugs and medication as possible in the hopes of finding a solution. Now, experts are also eyeing to a “little blue pill” or Viagra: nitric oxide.

Coronavirus: Nitric Oxide Eyed as a Possible COVID-19 Cure and Answer to Ventilator Shortages