Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 1,928

Virological assessment of hospitalized patients with COVID-2019

The coronavirus disease 2019 (COVID-19) pandemic has had a global impact on all aspects of health care, including surgical procedures. For urologists, it has affected and will continue to influence how we approach the care of patients preoperatively, intraoperatively, and postoperatively. A risk-benefit assessment of each patient undergoing surgery should be performed during the COVID-19 pandemic based on the urgency of the surgery and the risk of viral illness and transmission. Patients with advanced age and comorbidities have a higher incidence of mortality. Routine preoperative testing and symptom screening is recommended to identify those with COVID-19. Adequate personal protective equipment (PPE) for the surgical team is essential to protect health care workers and ensure an adequate workforce. For COVID-19 positive or suspected patients, the use of N95 respirators is recommended if available. The anesthesia method chosen should attempt to minimize aerosolization of the virus. Negative pressure rooms are strongly preferred for intubation/extubation and other aerosolizing procedures for COVID-19 positive patients or when COVID status is unknown. Although transmission has not yet been shown during laparoscopic and robotic procedures, efforts should be made to minimize the risk of aerosolization. Ultra-low particulate air filters are recommended for use during minimally invasive procedures to decrease the risk of viral transmission. Thorough cleaning and sterilization should be performed postoperatively with adequate time allowed for the operating room air to be cycled after procedures. COVID-19 patients should be separated from noninfected patients at all levels of care, including recovery, to decrease the risk of infection. Future directions will be guided by outcomes and infection rates as social distancing guidelines are relaxed and more surgical procedures are reintroduced. Recommendations should be adapted to the local environment and will continue to evolve as more data become available, the shortage of testing and PPE is resolved, and a vaccine and therapeutics for COVID-19 are developed.

The first reported cases of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), originated in Wuhan City, Hubei Province, China in December 2019. This respiratory disease spread outside of China, leading to outbreaks in Korea, Iran, Italy, and, eventually, the United States and the rest of the world. On March 11, 2020, the World Health Organization (WHO) declared the outbreak to be a pandemic. At the time of this writing, there are currently more than 1.3 million confirmed cases worldwide, with the total deaths numbering more than 74,000.1 This pandemic is unlike anything that has been seen in recent history.

From a urologic surgery perspective, many questions arise regarding the immediate and long-term care of our patients. The goal of this article is to summarize some of the current information available on preoperative, intraoperative, and postoperative care. As we gain more knowledge about how the virus behaves, this body of literature will inevitably change.

‘Cold Tube’ Invented to Beat the Summer Heat More Efficiently Than Air Conditioning

Chilled panels use less energy than conventional A/C and work in open spaces.

Many people beat the summer heat by cranking the air conditioning. However, air conditioners guzzle power and spew out millions of tons of carbon dioxide daily. They’re also not always good for your health—constant exposure to central A/C can increase risks of recirculating germs and causing breathing problems.

There’s a better alternative, say a team of researchers from the University of British Columbia, Princeton University, the University of California, Berkeley and the Singapore-ETH Centre.

Razer CEO says Covid-19 has accelerated path to the ‘Metaverse’, where content, commerce and networking exist in true virtual world

Min-Liang Tan, chief executive of gaming company Razer, said that the Covid-19 pandemic is driving the internet to the next stage of its evolution – something called the ‘Metaverse’ where cyberspace becomes more of an interactive 3D space with commerce and networking alongside content, much like the worlds in popular games such as Fortnite and Roblox.

The metaverse concept was brought to life by the 2018 sci-fi movie Ready Player One, directed by Steven Spielberg.

Sheep-Human Hybrids Made in Lab—Get the Facts

The embryos, which were not allowed to develop past 28 days of age, move researchers a small step closer to perhaps growing human organs for medical transplant.

Every hour, six people in the United States are added to the national waiting list for organ transplants—and each day, 22 people on the list die waiting. In the U.S. alone, more than a hundred thousand people need heart transplants each year, but only about 2,000 receive one.

In response, researchers are working to artificially expand the organ supply. Some are trying to 3D print organs in the lab. Others are working on artificial, mechanical organs. And some are making chimeras—hybrids of two different species—in the hopes of growing human organs in pigs or sheep.

Activation of TRPA1 nociceptor promotes systemic adult mammalian skin regeneration

Could speed up healing.

Wound healing in mammalian skin often results in fibrotic scars, and the mechanisms by which original nonfibrotic tissue architecture can be restored are not well understood. Here, Wei et al. have shown that pharmacological activation of the nociceptor TRPA1, which is found on cutaneous sensory neurons, can limit scar formation and promote tissue regeneration. They confirmed the efficacy of TRPA1 activation in three different skin wounding mouse models, and they also observed that localized activation could generate a response at distal wound sites. TRPA1 activation induced IL-23 production by dermal dendritic cells, which activated IL-17–producing γδ T cells and promoted tissue regeneration. These findings provide insight into neuroimmune signaling pathways in the skin that are critical to mammalian tissue regeneration.

Adult mammalian wounds, with rare exception, heal with fibrotic scars that severely disrupt tissue architecture and function. Regenerative medicine seeks methods to avoid scar formation and restore the original tissue structures. We show in three adult mouse models that pharmacologic activation of the nociceptor TRPA1 on cutaneous sensory neurons reduces scar formation and can also promote tissue regeneration. Local activation of TRPA1 induces tissue regeneration on distant untreated areas of injury, demonstrating a systemic effect. Activated TRPA1 stimulates local production of interleukin-23 (IL-23) by dermal dendritic cells, leading to activation of circulating dermal IL-17–producing γδ T cells. Genetic ablation of TRPA1, IL-23, dermal dendritic cells, or γδ T cells prevents TRPA1-mediated tissue regeneration.

750 million genetically engineered mosquitoes approved for release in Florida Keys

A plan to release over 750 million genetically modified mosquitoes into the Florida Keys in 2021 and 2022 received final approval from local authorities, against the objection of many local residents and a coalition of environmental advocacy groups. The proposal had already won state and federal approval.

“With all the urgent crises facing our nation and the State of Florida — the Covid-19 pandemic, racial injustice, climate change — the administration has used tax dollars and government resources for a Jurassic Park experiment,” said Jaydee Hanson, policy director for the International Center for Technology Assessment and Center for Food Safety, in a statement released Wednesday.

“Now the Monroe County Mosquito Control District has given the final permission needed. What could possibly go wrong? We don’t know, because EPA unlawfully refused to seriously analyze environmental risks, now without further review of the risks, the experiment can proceed,” she added.

Elon Musk reveals new details of Neuralink

In this video, Elon Musk demonstrates a prototype brain–computer interface chip – implanted in a pig – that his company, Neuralink, has been working on. The device could one day be used by humans to augment their abilities.

Founded in 2016, the Neuralink Corporation remained highly secretive about its work until July 2019, when Musk presented his concept at the California Academy of Sciences. It emerged that he planned to create brain–machine interfaces (BMIs) not only for diseased or injured patients, but also healthy individuals who might wish to enhance themselves.

Yesterday, in a livestream event on YouTube, Musk unveiled a pig called Gertrude with a coin-sized chip in her brain. Simpler and smaller than the original revealed last year, the read/write link device can nevertheless pack 1,024 channels with megabit wireless data rate and all-day battery life. This latest prototype – version 0.9 – has now been approved as an FDA breakthrough device, allowing it to be used in limited human trials under the US federal guidelines for testing medical devices. The chip is removable, Musk explained, as he showed another pig called Dorothy, who no longer had the implant and was healthy, happy and indistinguishable from a normal pig.

Which OCD Treatment Works Best? New Brain Study Could Lead to More Personalized Choices

Summary: Neuroimaging predicts whether a person with OCD will respond to stress-reduction therapy or exposure-based therapy best. Analyzing brain activity may help to provide tailored treatments to individuals suffering from OCD.

Source: Michigan Medicine

New research could improve the odds that people with obsessive-compulsive disorder will receive a therapy that really works for them – something that eludes more than a third of those who currently get OCD treatment.

Ambitious designs for underwater ‘space station’ and habitat unveiled

Sixty feet beneath the surface of the Caribbean Sea, aquanaut Fabien Cousteau and industrial designer Yves Béhar are envisioning the world’s largest underwater research station and habitat.

The pair have unveiled Fabien Cousteau’s Proteus, a 4,000-square-foot modular lab that will sit under the water off the coast of Curaçao, providing a home to scientists and researchers from across the world studying the ocean — from the effects of climate change and new marine life to medicinal breakthroughs.

Designed as a two-story circular structure grounded to the ocean floor on stilts, Proteus’ protruding pods contain laboratories, personal quarters, medical bays and a moon pool where divers can access the ocean floor. Powered by wind and solar energy, and ocean thermal energy conversion, the structure will also feature the first underwater greenhouse for growing food, as well as a video production facility.