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Category: biotech/medical – Page 1,928

Reimagining the laser: New ideas from quantum theory could herald a revolution

Lasers were created 60 years ago this year, when three different laser devices were unveiled by independent laboratories in the United States. A few years later, one of these inventors called the unusual light sources “a solution seeking a problem”. Today, the laser has been applied to countless problems in science, medicine and everyday technologies, with a market of more than US$11 billion per year.

A crucial difference between lasers and traditional sources of light is the “temporal coherence” of the light beam, or just coherence. The coherence of a beam can be measured by a number C, which takes into account the fact light is both a wave and a particle.

From even before lasers were created, physicists thought they knew exactly how coherent a laser could be. Now, two new studies (one by myself and colleagues in Australia, the other by a team of American physicists) have shown C can be much greater than was previously thought possible.

Uppsala in Last Preclinical Stage for New CAR T-cell Product for Glioblastoma

Researchers at Uppsala University, in Sweden, in collaboration with the SciLifeLab Drug Discovery and Development Platform, have taken “a large step forward” in developing a potential CAR T-cell therapy for glioblastoma, an aggressive form of brain cancer that is often difficult to treat.

Their project is now entering the final preclinical stage of development, according to the university. The goal is to start clinical studies within four years.

“Extremely few breakthroughs have been made around treating Glioblastoma,” Magnus Essand, professor of gene therapy at Uppsala, said in a press release.

Advanced Technology: Science Fiction to Science Fact and Encouraging a Culture of Responsibility

Human body bio-factories of tommorow for organ and tissue replacement.

Ira Pastor, ideaXme life sciences ambassador interviews Dr Alexander Titus Chief Strategy Officer (CSO) at the Advanced Regenerative Manufacturing Institute (ARMI).

Ira Pastor comments:

The Advanced Regenerative Manufacturing Institute (ARMI) is one of 14 institutes of the Manufacturing USA network, and is a member-driven, non-profit organization, whose mission is to make practical the large-scale manufacturing of engineered tissues and tissue-related technologies.

BioFabUSA, created by ARMI, was established to lead the charge in large-scale manufacturing of engineered tissues and regenerative medicine research, turning foundational breakthroughs in the manufacture of engineered tissues and tissue-related technologies into life-changing possibilities for everyone.

Continue reading “Advanced Technology: Science Fiction to Science Fact and Encouraging a Culture of Responsibility” | >

Can lab-grown brains become conscious?

Researchers are now calling for a set of guidelines, similar to those used in animal research, to guide the humane use of brain organoids and other experiments that could achieve consciousness. In June, the US National Academies of Sciences, Engineering, and Medicine began a study with the aim of outlining the potential legal and ethical issues associated with brain organoids and human-animal chimaeras.

A handful of experiments are raising questions about whether clumps of cells and disembodied brains could be sentient, and how scientists would know if they were.

Multifunctional skin-mounted microfluidic device able to measure stress in multiple ways

An international team of researchers has developed a multifunctional skin-mounted microfluidic device that is able to measure stress in people in multiple ways. In their paper published in Proceedings of the National Academy of Sciences, the group describes their device and how it could be useful.

Prior research has shown that can damage a person’s health. It can lead to diabetes, depression, obesity and a host of other problems. Some have suggested that one of the ways to combat stress is to create a means for alerting a person to their heightened stress so that they might take action to reduce it. To that end, prior teams have developed skin-adhesive devices that that collect sweat samples. The tiny samples contain small amounts of cortisol, a hormone that can be used as a marker of stress levels. In this new effort, the researchers have improved on these devices by developing one that measures more than just cortisol levels and is much more comfortable.

The researchers began with the notion that in order to convince people to wear a full time, it had to be both useful and comfortable. The solved the latter issue by making their device out of soft materials that adhere gently to the skin. They also used a skeletal design for their microfluidic sweat-collection apparatus—a flexible mesh. They also added more functionality. In addition to cortisol, their device is able to measure glucose and vitamin C levels. They also added electrodes underneath that are able to measure sweat rate and electrical conductivity of the skin, both of which change in response to stress. They also added a wireless transmitter that sends all of the data to a nearby smartphone running the device’s associated app.

A major milestone for an underground dark matter search experiment

Crews working on the largest U.S. experiment designed to directly detect dark matter completed a major milestone last month, and are now turning their sights toward startup after experiencing some delays due to global pandemic precautions.

U.S. Department of Energy officials on Sept. 21 formally signed off on project completion for LUX-ZEPLIN, or LZ: an ultrasensitive experiment that will use 10 metric tons of liquid xenon to hunt for signals of interactions with theorized dark matter particles called WIMPs, or weakly interacting massive particles. DOE’s project completion milestone is called Critical Decision 4, or CD-4.

Dark matter makes up an estimated 85 percent of all matter in the universe. We know it’s there because of its observed gravitational effects on normal matter, but we don’t yet know what it is. LZ is designed to detect the two flashes of light that occur if a WIMP interacts with the nucleus of a xenon atom.

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