Lifeboat Foundation

Last year, resTORbio announced the positive results of its phase 2b human trial, which targeted the aging immune system with an immune system-boosting drug. Now, the company has announced the news that its therapy is moving to a phase 3 study later this year after successful negotiation with the FDA.

Targeting the mTOR pathway of aging

ResTORbio is a biopharmaceutical company that is developing therapies that directly target the aging processes in order to prevent or cure age-related diseases. Its primary candidate drug is RTB101, which targets part of the mTOR pathway, one of the pathways involved in aging.

A new study shows clear differences in the biology of how men and women feel pain, a reminder that sex-specific pain medications might benefit us all.

The link between heart disease and depression could be inflammation, research suggests.

The two conditions have been heavily linked to each other for years but scientists have struggled to explain why this is.

Now experts have found inflammation — the body’s first line of defence — could be to blame.

Continue reading “Heart disease and depression are linked” »

A common calcium-channel blocking heart medication has been tentatively linked to increased risk of sudden cardiac arrest. The research comes from the European Sudden Cardiac Arrest network (ESCAPE-NET), though additional work is needed to determine whether the findings can be replicated. At the heart of the study were medications amlodipine and nifedipine, which are prescribed for high blood pressure and chest pain called angina.

Researchers with the Stanford University School of Medicine found in a study sponsored by Apple and released Saturday that the company’s smartwatches can detect irregular heart rhythms.

Of the approximately 400,000 participants using Apple Watches in the eight-month study, 0.5 percent, or about 2,000 people, were sent irregular heart rhythm notifications.

“The results of the Apple Heart Study highlight the potential role that innovative digital technology can play in creating more predictive and preventive health care,” Lloyd Minor, dean of the Stanford School of Medicine, said in a statement.

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Clumps of harmful proteins that interfere with brain functions have been partially cleared in mice using nothing but light and sound.

Research led by MIT has found strobe lights and a low pitched buzz can be used to recreate brain waves lost in the disease, which in turn remove plaque and improve cognitive function in mice engineered to display Alzheimer’s-like behaviour.

It’s a little like using light and sound to trigger their own brain waves to help fight the disease.

Continue reading “Scientists ‘Clear’ Alzheimer’s Plaque From Mice Using Only Light And Sound” »

The skin is our first line of defense against invading pathogens, and scientists at UC San Francisco and the San Francisco Veterans Administration (VA) Health Care System believe that it may be a cause of inflammaging, the age-related chronic inflammation that encourages a number of age-related diseases to develop.

As we age, we generally experience a rise in this low-grade chronic inflammation, thus increasing our risk for developing a variety of age-related diseases. There are a number of proposed sources of inflammaging, including senescent cell accumulation, cell debris, immunosenescence, and increasing bacterial burden.

In a previous article, we talked about the potential role of bacterial burden in relation to the microbiota of the gut and the age-related failure of the gut membrane, which allows bacterial contamination to invade the body and increase bacterial burden and inflammation. The gut microbiota has been proposed to be an origin point of inflammaging, and researchers suggest that the skin could be another.

Continue reading “A Restorative Skin Cream May Reduce Inflammaging” »

As many labs have established, Dr. Zaghloul’s team knew that our episodic memories are controlled by neurons in at least two different parts of the brain, but they did not know exactly how the cells worked together to retrieve memories. Based on a growing of body of evidence, they suspected that the short, high frequency electrical waves seen in ripples may somehow be involved. For instance, two earlier patient studies suggested that ripples may be important for solidifying memories during sleep.

A sound, a smell, a word can all flood our minds with memories of past experiences. In a study of epilepsy patients, researchers at the National Institutes of Health found that split seconds before we recall these events tiny electrical waves, called ripples, may flow through key parts of our brains that help store our memories, setting the stage for successful retrieval.

“We showed for the first time that ripples may be the neural substrates through which the human brain successfully recalls memories,” said Kareem Zaghloul, M.D., Ph.D., a neurosurgeon-researcher at the NIH’s National Institute of Neurological Disorders and Stroke (NINDS) and senior author of the study published in Science. “These results help us understand how the brain processes the details of our past waking experiences or episodic memories.”

Continue reading “Our brains may ripple before remembering” »