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Published today in Science, the research team from the Peter Doherty Institute for Infection and Immunity (Doherty Institute), the Olivia Newton-John Cancer Research Institute and CSL Limited say this breakthrough of discovering how gamma-delta T cells become activated addresses a question that has baffled scientists for 25 years.

The study by University of Melbourne’s Marc Rigau, Ph.D. student at the Doherty Institute, was co-led by Dr. Adam Uldrich, a Senior Research Fellow at the Doherty Institute, Professor Dale Godfrey a laboratory head at the Doherty Institute, and Dr. Andreas Behren, a Laboratory Head from the Olivia Newton-John Cancer Research Institute.

Dr. Uldrich explained that gamma-delta T cells are known to respond to the presence of small molecules, known as phosphoantigens, that are produced by bacteria and cancer cells.

The year of treating the untreatable: 2019 breakthroughs that could transform medicine.

What the reasons underlying these impairments are is yet unclear but scientists at the Center for Regenerative Therapies of TU Dresden (CRTD) wanted to investigate if increasing the number of stem cells in the brain would help in recovering cognitive functions, such as learning and memory, that are lost during ageing.”

https://tu-dresden.de/tu-dresden/newsportal/news/verjuengung…en-maeusen

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Continue reading “We all will experience it at some point, unfortunately: The older we get the more our brains will find it difficult to learn and remember new things” »

Proteins are often called the working molecules of the human body. A typical body has more than 20,000 different types of proteins, each of which is involved in many functions essential to human life.

Now, Purdue University researchers have designed a novel approach to use deep learning to better understand how proteins interact in the body – paving the way to producing accurate structure models of protein interactions involved in various diseases and to design better drugs that specifically target protein interactions. The work is released online in Bioinformatics.

“To understand molecular mechanisms of functions of protein complexes, biologists have been using experimental methods such as X-rays and microscopes, but they are time- and resource-intensive efforts,” said Daisuke Kihara, a professor of biological sciences and computer science in Purdue’s College of Science, who leads the research team. “Bioinformatics researchers in our lab and other institutions have been developing computational methods for modeling protein complexes. One big challenge is that a computational method usually generates thousands of models, and choosing the correct one or ranking the models can be difficult.”

Guardian of the Amazon! — Come hear the recent ideaXme (http://radioideaxme.com/) episode where we are joined by Ms. Nemonte Nenquimo, President of the Waorani Pastaza Organization, CONCONAWEP (Coordinating Council of the Waorani Nationality of Ecuador), following their recent landmark legal victory against the Ecuadorian government, leading to 500,000 acres of Amazon rainforest protected from oil drilling and timber companies (English voice over — Spanish audio link to be posted soon) — #Ideaxme #Amazon #Rainforest #Jungle #Ecuador #Waorani #Huaorani #Amerindian #Environment #Trees #Herbal #EthnoMedicine #Sustainability #Ayahuasca #ClimateChange #GretaThunberg #Health #Wellness #Longevity #Aging #IraPastor #Bioquark #Regenerage

Ira Pastor, ideaXme exponential health ambassador, interviews Ms. Nemonte Nenquimo, President of the Waorani Pastaza Organization (CONCONAWEP — Coordinating Council of the Waorani Nationality of Ecuador). This is an English language voice over of Ms Nenquimo’s audio interview.

Continue reading “Guardian of The Amazon: Ms Nenquimo protects environment and health for her people and the world” »

Scientists at Rutgers University-Newark have discovered that when a key protein needed to generate new brain cells during prenatal and early childhood development is missing, part of the brain goes haywire—causing an imbalance in its circuitry that can lead to long-term cognitive and movement behaviors characteristic of autism spectrum disorder.

“During brain development, there is a coordinated series of events that have to occur at the right time and the right place in order to establish the appropriate number of cells with the right connections,” said Juan Pablo Zanin, Rutgers-Newark research associate and lead author on a paper published in the Journal of Neuroscience.” Each of these steps is carefully regulated and if any of these steps are not regulated correctly, this can impact behavior.”

Zanin has been working with Wilma Friedman, professor of cellular neurobiology in the Department of Biological Sciences, studying the p75NTR protein—needed to regulate cell division—to determine its exact function in brain development, gain a better understanding of how this genetic mutation could cause brain cells to die off and discover whether there is a genetic link to autism or neurological diseases like Alzheimer’s.

Findings from a recent research project, conducted by a Marshall University scientist and assistant professor in the Marshall University College of Science, with researchers in Texas, was recently published in the December issue of the prestigious online journal, Nature Communications.

Dr. Eugene Shakirov is studying the connection between ribosomes and telomeres in plants. Telomeres are the physical ends of chromosomes and they shorten with age in most cells. Accelerated shortening of telomeres is linked to age-related diseases and overly long telomeres are often linked to cancer.

Telomere length varies between individuals at birth and is known to predetermine cellular lifespan, but the genes establishing telomere length variations are largely unknown. The research being done by Shakirov, along with collaborators at the University of Texas at Austin, Texas A&M University, HudsonAlpha Institute for Biology and the Kazan Federal University in Russia focused on the study of the genetic and epigenetic causes of natural telomere length variation in Arabidopsis thaliana, a small flowering plant.