Ketamine and Naltrexone you say? Weird.

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Ideal new treatments for Novel Coronavirus-19 (COVID-19) would help halt the progression disease in patients with mild disease prior to the need for artificial respiration (ventilators), and also provide a rescue treatment for patients with severe disease, while also being affordable and available in quantities sufficient to treat large numbers of infected people. Low doses of Naltrexone, a drug approved for treating alcoholism and opiate addiction, as well as Ketamine, a drug approved as an anesthetic, may be able to interrupt the inflammation that causes the worst COVID-19 symptoms and prove an effective new treatment. This study will investigate their effectiveness in a randomized, blinded trial versus standard treatment plus placebo.

Detailed Description:

There is an urgent need to develop new treatments for Novel Coronavirus-19 (COVID-19) infection using easily available and affordable medications. We need to develop a treatment protocol which prevents progression of the disease and a treatment protocol to rescue those with advanced disease. In addition to anti-viral therapeutics currently under investigation in other trials, the addition of immunomodulators to the treatment regimen appears have to potential to act as agents which can reduce the pathogenicity of this disease by reducing the dysregulation of autoimmunity which is destructive of normal tissue and when unchecked rapidly leads to mortality.

Aytu BioScience announced on April 20, four days before the Trump remarks, that it has signed an exclusive licensing deal with Cedars Sanai Medical Center in Los Angeles. The center has developed and is testing a UV-A “Healight” designed to be inserted via a catheter inside the trachea to kill pathogens, including the coronavirus.

Ultraviolet, or UV, light is commonly used by physicians to treat skin iseases. Cedars-Sanai says UV-A phototherapy potentially could be employed in internal organs.

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President Trump has been mocked relentlessly for suggesting that ultraviolet light could be brought “inside the body” to kill the coronavirus, but there is ongoing research to do just that.

For example, the pharmaceutical firm Aytu BioScience announced on April 20, four days before the Trump remarks, that it has signed an exclusive licensing deal with Cedars-Sinai Medical Center in Los Angeles. The center has developed and is testing a UV-A “Healight” designed to be inserted via a catheter inside the trachea to kill pathogens, including the coronavirus.

COVID-19’s genes are encoded in RNA instead of DNA. COVID-19 uses reverse transcriptase to transform its single-stranded RNA into double-stranded DNA. It is DNA that stores the genome of human cells and cells from other higher life forms. Once transformed from RNA to DNA, the new COVID-19 DNA can be integrated into the genome of the infected cells. When the DNA versions of the retroviral genes have been incorporated into the genome, the cell then is tricked into copying those genes as part of its normal replication process and making millions of COVID-19 cells… In other words, the cell does the work of the virus for it.

That’s why it was necessary to upgrade Stem Cell Neurotherapy for COVID-19 by adding T-Cells, B-Cells, and Natural Killer Cells to the arsenal. It was not enough to just regenerate new lung cells to replace the lung cells infected by COVID-19, but the COVID-19 Virus Cells had to be attacked and destroyed, and its RNA single strand had to be unraveled, in order to prevent them from invading and infecting the newly regenerated lung cells.

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A retrovirus is a virus whose genes are encoded in RNA, and, using an enzyme called reverse transcriptase, replicates itself by first reverse-coding its genes into the DNA of the cells it infects. Like other viruses, retroviruses need to use the cellular machinery of the organisms they infect to make copies of themselves. However, infection by a retrovirus requires an additional step. The retrovirus genome needs to be reverse-transcribed into DNA before it can be copied in the usual way. The enzyme that does this backward transcription is known as reverse transcriptase.

Retroviruses use reverse transcriptase to transform their single-stranded RNA into double-stranded DNA. It is DNA that stores the genome of human cells and cells from other higher life forms. Once transformed from RNA to DNA, the viral DNA can be integrated into the genome of the infected cells. When the DNA versions of the retroviral genes have been incorporated into the genome, the cell then is tricked into copying those genes as part of its normal replication process. In other words, the cell does the work of the virus for it.

The ESA’s fifth call for medium-class missions (M5) is in its full study phase. Three finalists, EnVision, SPICA, and THESEUS, remain from more than two dozen proposals. A selection will be made in the summer of 2021, with a launch date tentatively set for 2032. In February, the author attended the EnVision conference in Paris, and reported on the progress of that consortium. The THESEUS meeting is meant to be in Malaga, Spain, in May, and the SPICA collaboration was scheduled for March 9–11 in Leiden, The Netherlands. Unfortunately, the COVID-19 pandemic intervened and the physical meeting was cancelled. Instead, the group met via Zoom teleconference.

Cosmic Vision is the moniker for the ESA’s current space science campaign. Formulated in 2005, it succeeded the Horizon 2000 Plus campaign and described a number of different mission classes in the fields of astronomy, solar system exploration, and fundamental physics beyond 2015. Early on, it was decided that their overall scientific goals would center around four fundamental questions: