Lifeboat Foundation

When a virus invades your cells, it changes your body. But in the process, the pathogen changes its shape, too. A new mathematical model predicts the points on the virus that allow this shape-shifting to occur, revealing a new way to find potential drug and vaccine targets. The unique math-based approach has already identified potential targets in the coronavirus that causes COVID-19.

Outlined in April in the Journal of Computational Biology, the strategy predicts protein sites on viruses that stash energy—important spots that drugs could disable. In a rare feat, the work proceeds from pure mathematics, says study author and mathematician Robert Penner of the Institute of Advanced Scientific Studies in France. “There’s precious little pure math in biology,” he adds. The paper’s predictions face a long road before they can be verified experimentally, says John Yin, who studies viruses at the University of Wisconsin–Madison and was not involved in the research. But he agrees that Penner’s approach has potential. “He’s coming at this from a mathematician’s point of view—but a very scientifically informed mathematician,” Yin says. “So that’s highly rare.”

Penner’s method takes advantage of the fact that certain viral proteins alter their shape dramatically when viruses breach cells, and this transformation depends on unstable features. (A stable protein site, by definition, resists change.) By identifying “high free energy sites”—areas on a viral protein that store lots of energy—Penner realized he could spot likely “spring” points that mediate this change in shape. He calls such high-energy spots exotic sites. Finding them required some complex math.

Food contains many bioactive molecules similar to anti-cancer drugs. ML can discover such components and design cancer-beating hyperfoods.

The food we eat contains thousands of bioactive molecules, some of which are similar to anti-cancer drugs. Modern machine learning techniques can help discover such components and help design “hyperfoods” that will let us live longer and healthier.

It’s essentially the guts of a smartphone combined with brain-implanted micro electrodes, as TechCrunch reports. The “Gennaris bionic vision system,” a project that’s more than ten years in the making, bypasses damaged optic nerves to allow signals to be transmitted from the retina to the vision center of the brain.

The system is made up of a custom-designed headgear, which includes a camera and a wireless transmitter. A processor unit takes care of data crunching, while a set of tiles implanted inside the brain deliver the signals.

“Our design creates a visual pattern from combinations of up to 172 spots of light (phosphenes) which provides information for the individual to navigate indoor and outdoor environments, and recognize the presence of people and objects around them,” Arthur Lowery, professor at Monash University’s Department of Electrical and Computer Systems Engineering, said in a statement.

Circa 2019

Monoclonal antibodies are man-made versions of immune system proteins (antibodies) that are designed to attach to a specific target (in this case, proteins on the surface of cancer cells). These drugs can help your immune system react to and destroy the cancer cells. Some monoclonal antibodies also fight cancer in other ways.

Chemo given along with a monoclonal antibody is a standard treatment for chronic lymphocytic leukemia (CLL).

The monoclonal antibodies used to treat CLL can be divided into groups based on which protein they target.

Continue reading “Monoclonal Antibodies for Chronic Lymphocytic Leukemia” »

In recent years we have seen the move away from ‘politics as usual’. Non-traditional figures have entered the political arena to disrupt the typical entrenched narratives. The election and worldwide popularity of Jacinda Ardern, New Zealand Prime Minister just one example of a new kind of leader who prioritises national wellbeing and happiness in the belief that everything else will follow.

Brigadier General (Retired) Dr. Loree Sutton Next Mayor of New York City?

Continue reading “Brigadier General Dr. Loree Sutton New York’s Next Mayor?” »

Emotional dysregulation and anxiety are common in people at clinical high risk for psychosis (CHR) and are associated with altered neural responses to emotional stimuli in the striatum and medial temporal lobe. Using a randomised, double-blind, parallel-group design, 33 CHR patients were randomised to a single oral dose of CBD (600 mg) or placebo. Healthy controls (n = 19) were studied under identical conditions but did not receive any drug. Participants were scanned with functional magnetic resonance imaging (fMRI) during a fearful face-processing paradigm. Activation related to the CHR state and to the effects of CBD was examined using a region-of-interest approach. During fear processing, CHR participants receiving placebo (n = 15) showed greater activation than controls (n = 19) in the parahippocampal gyrus but less activation in the striatum. Within these regions, activation in the CHR group that received CBD (n = 15) was intermediate between that of the CHR placebo and control groups. These findings suggest that in CHR patients, CBD modulates brain function in regions implicated in psychosis risk and emotion processing. These findings are similar to those previously evident using a memory paradigm, suggesting that the effects of CBD on medial temporal and striatal function may be task independent.

By studying the DNA of people who lived in East Asia thousands of years ago, scientists are starting to untangle how the region was populated.

Scientists at the University of Pittsburgh School of Medicine have isolated “the smallest biological molecule” that “completely and specifically neutralizes” the virus that causes COVID-19.

The antibody component is 10 times smaller than a full-size antibody, and has been used to create the drug Ab8, shared in the report published by the researchers in the journal Cell on Monday. The drug is seen as a potential preventative against SARS-CoV-2.

According to the report, the drug has been “highly effective in preventing and treating” SARS-CoV-2 infections in mice and hamsters during tests. The drug also reportedly does not bind to human cells, which suggests it will not have negative side effects in people.

Gold isn’t just a pretty face – it’s shown promise in fighting cancer in many studies. Now researchers have found a way to grow gold nanoparticles directly inside cancer cells within 30 minutes, which can help with imaging and even be heated up to kill the tumors.

Gold isn’t just a pretty face – it’s shown promise in fighting cancer in many studies. Now researchers have found a way to grow gold nanoparticles directly inside cancer cells within 30 minutes, which can help with imaging and even be heated up to kill the tumors.

In previous work, gold nanostars, nanotubes and other nanoparticle structures have been sent into battle against cancer, but one of the main hurdles is getting the stuff inside the tumors. Sometimes they’re equipped with peptides that hunt down cancer, while others sneak in attached to white blood cells.

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