Stress, via the paraventricular thalamus, modifies the central pacemaker and interacts with light to influence circadian outputs.
Category: biotech/medical – Page 13
Scientists find cellular brain changes tied to PTSD
The human brain is made up of billions of interconnected cells that are constantly talking to each other. A new study published in Nature zooms in to the single-cell level to see how this cellular communication may be going wrong in brains affected by post-traumatic stress disorder (PTSD).
Until recently, researchers did not have the technology to study genetic variation within individual cells. But now that it’s available, a team led by Matthew Girgenti, Ph.D., assistant professor of psychiatry at Yale School of Medicine, has been analyzing brain cells to uncover genetic variants that might be associated with psychiatric diseases such as major depressive disorder (MDD) and PTSD.
Their latest study is one of the first to examine a major psychiatric disorder, PTSD, at the single-cell level. For years, doctors have been prescribing antidepressants to treat the condition because there are currently no drugs specifically designed for PTSD. Girgenti hopes that identifying novel molecular signatures associated with the psychiatric disease can help researchers learn how to develop new drugs or repurpose existing ones to treat it more effectively.
Scientists demonstrate unconditional exponential quantum scaling advantage using two 127-qubit computers
Quantum computers have the potential to speed up computation, help design new medicines, break codes, and discover exotic new materials—but that’s only when they are truly functional.
One key thing that gets in the way: noise or the errors that are produced during computations on a quantum machine—which in fact makes them less powerful than classical computers —until recently.
Daniel Lidar, holder of the Viterbi Professorship in Engineering and Professor of Electrical & Computer Engineering at the USC Viterbi School of Engineering, has been iterating on quantum error correction, and in a new study along with collaborators at USC and Johns Hopkins, has been able to demonstrate a quantum exponential scaling advantage, using two 127-qubit IBM Quantum Eagle processor-powered quantum computers, over the cloud.
Embryos can eliminate bacterial infections before forming their immune system, new research shows
Research led by scientists from the Institute of Molecular Biology of Barcelona (IBMB) of the CSIC and the Bellvitge Biomedical Research Institute (IDIBELL) has managed to film how a few days-old embryos defend themselves from a potential infection by bacteria. The work is published this week in the journal Cell Host and Microbe.
Specifically, they have been able to see how zebrafish embryos use cells present on their surface, known as epithelial cells, to ingest and destroy bacteria through a process called phagocytosis, similar to that carried out by white blood cells. Crucially, scientists could observe that this ability to eliminate bacteria is also present in human embryos.
Using state-of-the-art microscopy techniques, the research shows how cells capture Escherichia coli and Staphylococcus aureus bacteria through small protrusions of their membrane, in which the protein Actin is involved. “Our research shows that, at the beginning of development—before implantation in the uterus and before the formation of organs—embryos already have a defense system that allows them to eliminate bacterial infections,” says Esteban Hoijman, researcher at IBMB-CSIC and IDIBELL, leader of the research.
Scale of how chronic fatigue syndrome affects patients’ blood shown for first time
People with ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome) have significant differences in their blood compared with healthy individuals, a new study reveals, suggesting a path toward more reliable diagnosis of the long-term debilitating illness. The paper is published in the journal EMBO Molecular Medicine.
The largest ever biological study of ME/CFS has identified consistent blood differences associated with chronic inflammation, insulin resistance, and liver disease.
Significantly, the results were mostly unaffected by patients’ activity levels, as low activity levels can sometimes hide the biological signs of illness, experts say.
Magically reducing errors in quantum computers: Researchers invent technique to decrease overhead
For decades, quantum computers that perform calculations millions of times faster than conventional computers have remained a tantalizing yet distant goal. However, a new breakthrough in quantum physics may have just sped up the timeline.
In an article titled “Efficient Magic State Distillation by Zero-Level Distillation” published in PRX Quantum, researchers from the Graduate School of Engineering Science and the Center for Quantum Information and Quantum Biology at the University of Osaka devised a method that can be used to prepare high-fidelity “magic states” for use in quantum computers with dramatically less overhead and unprecedented accuracy.
Quantum computers harness the fantastic properties of quantum mechanics such as entanglement and superposition to perform calculations much more efficiently than classical computers can. Such machines could catalyze innovations in fields as diverse as engineering, finance, and biotechnology. But before this can happen, there is a significant obstacle that must be overcome.
Intercellular fluid flow, not just cell structure, governs how tissues respond to physical forces
Water makes up around 60% of the human body. More than half of this water sloshes around inside the cells that make up organs and tissues. Much of the remaining water flows in the nooks and crannies between cells, much like seawater between grains of sand.
Now, MIT engineers have found that this “intercellular” fluid plays a major role in how tissues respond when squeezed, pressed, or physically deformed. Their findings could help scientists understand how cells, tissues, and organs physically adapt to conditions such as aging, cancer, diabetes, and certain neuromuscular diseases.
In a paper appearing in Nature Physics, the researchers show that when a tissue is pressed or squeezed, it is more compliant and relaxes more quickly when the fluid between its cells flows easily. When the cells are packed together and there is less room for intercellular flow, the tissue as a whole is stiffer and resists being pressed or squeezed.
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Cells assembled into Anthrobots become biologically younger than the original cells they were made from
Modern humans have existed for more than 200,000 years, and each new generation has begun with a single cell—dividing, changing shape and function, organizing into tissues, organs, and limbs. With slight variations, the process has repeated billions of times with remarkable fidelity to the same body plan.
Researchers at Tufts have been on a quest to understand the code guiding individual cells to create the architecture of a human being, and to create a foundation for regenerative medicine. As they learn more about that code, they are also looking at how to build living structures from human cells that have totally new forms and capabilities—without genetic manipulation.
To decipher that code, they took a cell from the human body and allowed it to grow in a novel environment to observe how the rules of self-organization play out.