Lifeboat Foundation

Bioprinting new organs and tissues could make transplants available and affordable for all, but is still decades away. In the meantime, scientists have re-purposed the technology to 3D print biocompatible high-precision silicone implants instead.

Soft materials like biological material or silicone are difficult to 3D print because they can’t support themselves like the more rigid plastics typically used by 3D printers. In 2015, Tommy Angelini’s lab at the University of Florida developed a new way of 3D printing soft materials by injecting them into a granular gel similar to hand sanitizer that supports them as they are deposited.

Continue reading “3D Printed Medical Implants That Fit the Body Perfectly Are on the Way” »

Every day in a San Diego lab, raw material derived from donated tissue unsuitable for organ transplantation goes into a machine, and three-dimensional human liver tissue is printed out.

Pioneered by a company called Organovo, this 3D bioprinting technology may one day achieve the Holy Grail of its industry: the manufacturing of whole human organs to replace damaged ones. But for now, it’s already making an impact on human health, as pharmaceutical and biotech companies are using its manufactured human liver tissue to test the toxicity of new drugs and therapies.

Organovo is developing multiple tissue types for therapeutic use, with strong early results in animal models. In three to five years, there’s a good chance that it will have an Investigational New Drug Application in at least one tissue. The company’s strategic plan is coming to fruition just as its chief scientific officer, Sharon Presnell, envisioned when she joined the startup in 2011.

The new research, led by nanoengineering professor Shaochen Chen, addresses one of the biggest challenges in tissue engineering: creating lifelike tissues and organs with functioning vasculature — networks of blood vessels that can transport blood, nutrients, waste and other biological materials — and do so safely when implanted inside the body.

Researchers from other labs have used different 3D printing technologies to create artificial blood vessels. But existing technologies are slow, costly and mainly produce simple structures, such as a single blood vessel — a tube, basically. These blood vessels also are not capable of integrating with the body’s own vascular system.

“Almost all tissues and organs need blood vessels to survive and work properly. This is a big bottleneck in making organ transplants, which are in high demand but in short supply,” said Chen, who leads the Nanobiomaterials, Bioprinting, and Tissue Engineering Lab at UC San Diego. “3D bioprinting organs can help bridge this gap, and our lab has taken a big step toward that goal.”

Continue reading “Nanoengineers 3D print biomimetic blood vessel networks” »

Researchers from the University of California, San Diego have successfully 3D printed a framework of functional blood vessels. Blood vessel networks are important in transporting blood, nutrients and waste around the human body.

The research team employed a 3D bioprinting process involving hydrogel and endothelial cells. Endothelial are the form of cells that make up the inner lining of blood vessels.

Leading the research was Shaochen Chen, who explains the motivation of the project.

Continue reading “Californian researchers 3D print functioning blood vessels” »

A 3D bioprinter able to create human skin is already being used to help burns patients and carry out skin testing, Alfredo Brisac, CEO of Spanish bioengineering company BioDan, told Radio Sputnik.

Last month, scientists at Universidad Carlos III de Madrid and the BioDan Group presented a prototype 3D bioprinter that can create human skin suitable for transplantation to patients or for use in cosmetic, chemical or pharmaceutical testing.

One of the first living human organs to be created using bioprinting, the 3D-printed skin is created using bio-inks with living cells that are deposited onto a structure that replicates nature. The bio-ink contains the key elements of keratinocytes, fibroblasts and fibrin, which can recreate the structure of the skin.

Scientists from the Universidad Carlos III de Madrid (UC3M), CIEMAT (Center for Energy, Environmental and Technological Research), Hospital General Universitario Gregorio Marañón, in collaboration with the firm BioDan Group, have presented a prototype for a 3D bioprinter that can create totally functional human skin. This skin is adequate for transplanting to patients or for use in research or the testing of cosmetic, chemical, and pharmaceutical products.

This research has recently been published in the electronic version of the scientific journal Biofabrication. In this article, the team of researchers has demonstrated, for the first time, that, using the new 3D printing technology, it is possible to produce proper human skin. One of the authors, José Luis Jorcano, professor in UC3M’s department of Bioengineering and Aerospace Engineering and head of the Mixed Unit CIEMAT/UC3M in Biomedical Engineering, points out that this skin “can be transplanted to patients or used in business settings to test chemical products, cosmetics or pharmaceutical products in quantities and with timetables and prices that are compatible with these uses.”

Continue reading “Bioprinter makes fully functional human skin” »

Highly sophisticated robotics and ‘bio-printing’ are rapidly changing the face of modern surgery, significantly eliminating the risk of human error and in some cases even allowing doctors to perform procedures remotely, according to experts at Arab Health.

Dr Peter C.W. Kim, vice-president and associate surgeon-in-chief of the Joseph E. Roberts Jr. Centre for Surgical Care at Washington DC’s Children’s National — which has received millions of dollars in donations from the UAE’s government — noted that doctors will soon be able to 3D-print using bio-tissue, such as for an eardrum.

“What our engineers and researchers have done is not only design the plastic with it, but also graft cells onto it,” he said. “This is where we are going. You will (in the future) be able to have organs on the shelf. Instead of harvesting it, you can print it.”

Continue reading “Robots and bio-printing change the face of surgery in UAE” »

The annual 3D Bioprinting Conference is underway in the Netherlands today. While printing human body parts remains largely experimental, there are growing signs of commercial activity.

More progress for tissue engineering.

Skin is one of the easier starting points for 3D bioprinting, the application of rapid prototyping technologies to the construction of living tissue. Since skin is a thin tissue, the challenging issue of producing the intricate blood vessel networks needed to supply inner cells with oxygen and nutrients can be skipped. Thin tissue sections can be supported in a suitable nutrient bath, and after transplant, patient blood vessels will grow into the new skin. Further, there is a fairly large and long-established research and development industry involved in various forms of skin regeneration. Numerous forms of prototype skin-like tissues have been created over the years, lacking many of the features of the real thing, but still useful in the treatment of, for example, burn victims. Further, skin structure is by now well understood, and considerable progress has been made in deciphering the signals and environment needed for suitable cells to self-assemble into the correct arrangements. All told, it should not be a complete surprise to see significant progress emerge in this part of the field.