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Category: biological – Page 36

Disagreement on foundational principles of biological aging

Abstract. To gain insight into how researchers of aging perceive the process they study, we conducted a survey among experts in the field. While highlighting some common features of aging, the survey exposed broad disagreement on the foundational issues. What is aging? What causes it? When does it begin? What constitutes rejuvenation? Not only was there no consensus on these and other core questions, but none of the questions received a majority opinion—even regarding the need for consensus itself. Despite many researchers believing they understand aging, their understanding diverges considerably. Importantly, as different processes are labeled as “aging” by researchers, different experimental approaches are prioritized. The survey shed light on the need to better define which aging processes this field should target and what its goals are. It also allowed us to categorize contemporary views on aging and rejuvenation, revealing critical, yet largely unanswered, questions that appear disconnected from the current research focus. Finally, we discuss ways to address the disagreement, which we hope will ultimately aid progress in the field.

Frontiers: A base on the Moon surface or a mission to Mars are potential destinations for human spaceflight, according to current space agencies’ plans

These scenarios pose several new challenges, since the environmental and operational conditions of the mission will strongly differ than those on the International Space Station (ISS). One critical parameter will be the increased mission duration and further distance from Earth, requiring a Life Support System (LSS) as independent as possible from Earth’s resources. Current LSS physico-chemical technologies at the ISS can recycle 90% of water and regain 42% of O2 from the astronaut’s exhaled CO2, but they are not able to produce food, which can currently only be achieved using biology. A future LSS will most likely include some of these technologies currently in use, but will also need to include biological components. A potential biological candidate are microalgae, which compared to higher plants, offer a higher harvest index, higher biomass productivity and require less water. Several algal species have already been investigated for space applications in the last decades, being Chlorella vulgaris a promising and widely researched species. C. vulgaris is a spherical single cell organism, with a mean diameter of 6 µm. It can grow in a wide range of pH and temperature levels and CO2 concentrations and it shows a high resistance to cross contamination and to mechanical shear stress, making it an ideal organism for long-term LSS. In order to continuously and efficiently produce the oxygen and food required for the LSS, the microalgae need to grow in a well-controlled and stable environment. Therefore, besides the biological aspects, the design of the cultivation system, the Photobioreactor (PBR), is also crucial. Even if research both on C. vulgaris and in general about PBRs has been carried out for decades, several challenges both in the biological and technological aspects need to be solved, before a PBR can be used as part of the LSS in a Moon base. Those include: radiation effects on algae, operation under partial gravity, selection of the required hardware for cultivation and food processing, system automation and long-term performance and stability.

The International Space Station (ISS) has been continuously inhabited for over twenty years. The Life Support System (LSS) on board the station is in charge of providing the astronauts with oxygen, water and food. For that, Physico-Chemical (PC) technologies are used, recycling 90% of the water and recovering 42% of the oxygen (O2) from the carbon dioxide (CO2) that astronauts produce (Crusan and Gatens, 2017), while food is supplied from Earth.

Space agencies currently plan missions beyond Low Earth Orbit, with a Moon base or a mission to Mars as potential future scenarios (ESA Blog 2016; ISEGC 2018; NASA 2020). The higher distance from Earth of a lunar base, compared to the ISS, might require the production of food in-situ, to reduce the amount of resources required from Earth. PC technologies are not able to produce food, which can only be achieved using biological organisms. Several candidates are currently being investigated, with a main focus on higher plants (Kittang et al., 2014; Hamilton et al., 2020) and microalgae (Detrell et al., 2020b; Poughon et al., 2020).

Tiny dancers: Scientists synchronize bacterial motion

Researchers at TU Delft have discovered that E. coli bacteria can synchronize their movements, creating order in seemingly random biological systems. By trapping individual bacteria in micro-engineered circular cavities and coupling these cavities through narrow channels, the team observed coordinated bacterial motion. Their findings, which have potential applications in engineering controllable biological oscillator networks, were recently published in Small.

An audience clapping in rhythm, fireflies flashing in unison, or flocks of starlings moving as one—synchronization is a natural phenomenon observed across diverse systems and scales. First described by Christiaan Huygens in the 17th century, synchronization was famously illustrated by the aligned swinging of his pendulum clocks. Now, TU Delft researchers have shown that even E. coli bacteria—single-celled organisms only a few micrometers long—can display this same phenomenon.

“This was a remarkable moment for our team,” said Farbod Alijani, associate professor at the Faculty of Mechanical Engineering. “Seeing bacteria ‘dance in sync’ not only showcases the beauty of nature but also deepens our understanding of the microscopic origins of self-organization among the smallest living organisms.”

NASA ROSES-24 Amendment 76: E.9 Space Biology: Research Studies Draft Text Released

When it is solicited, the research emphases of E.9 Space Biology: Research Studies will fall under two broad categories: Precision Health and Space Crops.

For Precision Health-focused studies, investigators may propose to use any non-primate animal model system, and any appropriate cell/tissue culture/ microphysiological system/ organoid or microbial models, that are supported by the chosen platform. For Space Crop-focused studies, applicants may propose to use any plant model system, and when appropriate, any microbial or plant and microbial model systems that are supported by the chosen platform.

This opportunity will include five different Project Types: Research Investigations, Early Career Research Investigations, New NASA Investigators, GeneLab Analytical Investigations, and Tissue Sharing Investigations.

Nutrients related to vitamin B12 influence microbial growth and reshape soil microbiomes, research finds

Communities of microbes (microbiomes), particularly in soils, can be startlingly diverse, with as many as 10,000 species in just a cup of material. Scientists are working to understand how microbiomes and their members respond to their environments. These processes can profoundly shape the properties and composition of soils.

In a pair of studies published in The ISME Journal, researchers investigated how different species of interact with one another and exchange resources such as vitamins. The studies focused on corrinoids, the vitamin B12 family of nutrients. Many bacteria in the environment cannot produce these chemicals.

Focusing on a single type of nutrient enables the study of microbiomes in greater detail. The two studies further synergized by focusing on the same California grassland soil, allowing the researchers to generate a framework for understanding in this system.

How Tech Is Breaking the Rules of Biology | Posthuman with Emily Chang

From birth to death, tech is stretching the boundaries of biology. In this episode of Posthuman, we explore the discoveries that could transform reproduction, healthcare and how we die.

Technology that once seemed like science fiction is rapidly becoming reality, transforming the very essence of our existence. In this four-part series, Emily Chang unravels the future of being human in an age of unprecedented innovation.

Watch more Posthuman with Emily Chang: • Posthuman with Emily Chang.

#Tech #Science #Posthuman.
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Novel quantum computing algorithm enhances single-cell analysis

A new quantum algorithm developed by University of Georgia statisticians addresses one of the most complex challenges in single-cell analysis, signaling significant impact in both the fields of computational biology and quantum computing.

The study, “Bisection Grover’s Search Algorithm and Its Application in Analyzing CITE-seq Data,” was published in the Journal of the American Statistical Association on Sept. 20.

While traditional approaches struggle to handle the immense amount of data generated from measuring both RNA and in individual cells, the new enables analysis of data from a single-cell technology known as CITE-seq. It allows for selection of the most important markers from billions of possible combinations—a task that would be formidable using classical methods.