Lifeboat Foundation

“Daniel Chao, a Stanford-trained neuroscientist, and Brett Wingeier, a biomedical engineer, founded Halo Neuroscience in 2013. … Halo Sport uses electrodes to stimulate the brain’s motor cortex, which controls planning and voluntary movements. Energized motor neurons send stronger signals to athletes’ muscles, which Chao says allows them to reap greater rewards from every rep.”

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A study of the embryonic nervous system of the fruit fly throws light on how two neuronal cell lineages that develop at different times and in different places in the ventral nerve cord of the embryo can ultimately result in very similar neuronal subtypes. The study, publishing in the Open Access journal PLOS Biology on 5th May, is a collaboration between research teams in Madrid (Spain) and Linköping (Sweden).

In the paper, Hugo Gabilondo, Johannes Stratmann and their colleagues report that a crucial terminal selector gene, col, is activated by different sets of spatio-temporal selector genes in the two different neuronal cell lineages. In dAp neurons, which are present throughout the thorax and abdominal segments, col is activated directly by the action of the early temporal genes Kruppel (Kr) and pdm, and the GATA transcription factor gene grain (grn). By contrast, in Tv1 neurons, which are specific to the thoracic segments, col is activated by the late temporal gene cas, together with several other genes that feed forward onto the terminal selector gene cascade downstream of col. The result is expression of the neuropeptide Nplp1 in both dAp and Tv1 neurons.

The developing nervous system generates many different neuronal cell types; understanding this process of cell fate specification remains a major challenge for biologists. Complex cascades of regulatory genes are known to be involved, starting with spatial and temporal selector genes and finishing with terminal selector genes, all of which act in various combinations to dictate the ultimate neuronal cell type. A particular neuronal cell type often arises in several parts of the nervous system and at different stages of development, however, suggesting that different spatio-temporal cues can converge on the same terminal selectors to generate a similar cell fate. This study reports evidence of this phenomenon in an example from the fruit fly, Drosophila melanogaster.

Continue reading “Gene cascade specifies two distinct neuron sets expressing Nplp1” »

They are worth 6 billion dollars.

They are calling him the Elon Musk of biology. But will we see an end to aging soon?

Continue reading “The End of Aging? Soon It Might Be a Prescription Away” »

Scientists have sustained human embryos in a petri dish for 13 days, shattering the previous record of nine days. The breakthrough will allow researchers to study early fetal development in unprecedented detail, and brings us one step closer to viable “artificial wombs.” But it’s adding fuel to an already heated ethical debate.

Two separate papers published this week, one in Nature and one in Nature Cell Biology, have reported culturing human embryos for nearly two weeks, going well beyond previous efforts. There’s no reason to believe that the embryos couldn’t have survived beyond the two-week mark, but the experiment had to be halted to adhere to the internationally agreed 14-day limit on human embryo research.

http://io9.gizmodo.com/how-to-build-an-artificial-womb-476464703

Continue reading “Artificial Wombs Just Got One Step Closer to Reality” »

How could global economic inequality survive the onslaught of synthetic organisms, micromanufacturing devices, additive manufacturing machines, nano-factories?
(http://www.beliefnet.com/columnists/lordre/2016/04/obsessed-…L36KMDo.99)

Narrated by Harry J. Bentham, author of Catalyst: A Techno-Liberation Thesis (2013), using the introduction from that book as a taster of the audio version of the book in production. (http://www.clubof.info/2016/04/liberation-technologies-to-come.html)

Continue reading “"Liberation technologies" and the ones who will gain” »

Now, that’s an exhibit!

May 5, 2016, will mark the opening of a new and exciting exhibit at Chicago’s famed Museum of Science and Industry: an in-depth and interactive look behind the curtain at the Defense Advanced Research Projects Agency (DARPA).

DARPA was created in 1958 at the peak of the Cold War in response to the Soviet Union’s launch of Sputnik, the world’s first manmade satellite, which passed menacingly over the United States every 96 minutes. Tasked with preventing such strategic surprises in the future, the agency has achieved its mission over the years in part by creating a series of technological surprises of its own, many of which are highlighted in the Chicago exhibit, “Redefining Possible.”

“We are grateful to Chicago’s Museum of Science and Industry for inviting us to tell the DARPA story of ambitious problem solving and technological innovation,” said DARPA Deputy Director Steve Walker, who will be on hand for the exhibit’s opening day. “Learning how DARPA has tackled some of the most daunting scientific and engineering challenges—and how it has tolerated the risk of failure in order to have major impact when it succeeds—can be enormously inspiring to students. And for adults, we hope the exhibit will serve as a reminder that some of the most exciting work going on today in fields as diverse as chemistry, engineering, cyber defense and synthetic biology are happening with federal support, in furtherance of pressing national priorities.”

Continue reading “DARPA Exhibit to Open at Chicago’s Museum of Science and Industry” »

Of course bio technology holds the key for better memory.

Newswise — A group of Boise State researchers, led by associate professor of materials science and engineering and associate dean of the College of Innovation and Design Will Hughes, is working toward a better way to store digital information using nucleic acid memory (NAM).

It’s no secret that as a society we generate vast amounts of data each year. So much so that the 30 billion watts of electricity used annually by server farms today is roughly equivalent to the output of 30 nuclear power plants.

Continue reading “Biology May Hold Key to Better Computer Memory” »

Many recent big technological advances in computing, communications, energy, and biology have relied on nanoparticles. It can be hard to determine the best nanomaterials for these applications, however, because observing nanoparticles in action requires high spatial resolution in “messy,” dynamic environments.

In a recent step in this direction, a team of engineers has obtained a first look inside phase-changing nanoparticles, showing how their shape and crystallinity—the arrangement of atoms within the crystal—can have dramatic effects on their performance.

The work, which appears in Nature Materials, has immediate applications in the design of energy storage materials, but could eventually find its way into data storage, electronic switches, and any device in which the phase transformation of a material regulates its performance.

I learn useful life lessons from each patient I meet. Some are positive messages, reminding me of the importance of maintaining balance between family, work, and leisure activities, but more frequently I witness examples of the remarkable resilience of the human spirit when facing the reality and risks of a major surgical procedure and a diagnosis of cancer. Rarely, patients and their family members utter remorseful or simply sad remarks when they are faced with a grim prognosis and the emotions associated with an onrushing date with mortality. These comments invariably involve an inventory of regrets in life, including, “I should have spent more time with my kids,” “I wish I had told my father (or mother, brother, sister, child, or some other person) that I loved them before they died,” and “I have spent my entire life working, I never took time for anything else.” I wince when I hear these openly expressed remonstrations, I recognize that I am hearing painful and heartfelt truths. Not a week goes by that I am not reminded that I do not one day want to look back at my life with a long list of regrets, should have dones, and what ifs.

I was blessed to meet a great teacher in the guise of a patient early in my academic career. He came to my clinic in my first year after completing a Fellowship in Surgical Oncology, my first year as an Assistant Professor of Surgery. My patient was a 69 year-old Baptist Minister from a small town in Mississippi. He was referred to me by his medical oncologist who called me and said, “I don’t think there is anything you can do for him, but he needs to hear that from you because he doesn’t believe me.” This tall, imposing man had colon cancer that had metastasized (spread) to his liver. The malignant tumor in his colon was removed the year before I met him, and he had received chemotherapy to treat several large tumors found in his liver. The chemotherapy had not worked and the tumors grew. At the point I met him, the medical oncologist told him he would live no more than 6 months, and because he was an avid fisherman when not preaching or helping others in his community , the doctor suggested that he go out and enjoy his remaining time by getting in as much fishing as possible. I learned two invaluable lessons from this patient and his family. First, never deny or dismiss hope from a patient or their family, even when from a medical perspective the situation seems hopeless and the patient is incurable. Second, quoting the minister directly, “Some doctors think of themselves as gods with a small ‘g’, but not one of you is God”.

Continue reading “The Importance of Hope” »