Lifeboat Foundation

Brain-inspired computing paradigms have led to substantial advances in the automation of visual and linguistic tasks by emulating the distributed information processing of biological systems. The similarity between artificial neural networks (ANNs) and biological systems has inspired ANN implementation in biomedical interfaces including prosthetics and brain-machine interfaces. While promising, these implementations rely on software to run ANN algorithms. Ultimately, it is desirable to build hardware ANNs that can both directly interface with living tissue and adapt based on biofeedback. The first essential step towards biologically integrated neuromorphic systems is to achieve synaptic conditioning based on biochemical signalling activity. Here, we directly couple an organic neuromorphic device with dopaminergic cells to constitute a biohybrid synapse with neurotransmitter-mediated synaptic plasticity. By mimicking the dopamine recycling machinery of the synaptic cleft, we demonstrate both long-term conditioning and recovery of the synaptic weight, paving the way towards combining artificial neuromorphic systems with biological neural networks.

The recent killings of unarmed individuals such as George Floyd, Breonna Taylor, Ahmaud Arbery and Tony McDade have sparked a national conversation about the treatment of Black people—and other minorities—in the United States.

“What we’re seeing today is a close examination of the hardships and indignities that people have faced for a very long time because of their race and ethnicity,” said Kyle Ratner, an assistant professor of psychological and brain sciences at UC Santa Barbara. As a social psychologist, he is interested in how social and biological processes give rise to intergroup bias and feelings of stigmatization.

According to Ratner, “It is clear that people who belong to historically marginalized groups in the United States contend with burdensome stressors on top of the everyday stressors that members of non-disadvantaged groups experience. For instance, there is the trauma of overt racism, stigmatizing portrayals in the media and popular culture, and systemic discrimination that leads to disadvantages in many domains of life, from employment and education to healthcare and housing to the legal system.”

Ribonucleic acid, or RNA, is part of our genetic code and present in every cell of our body. The best known form of RNA is a single linear strand, of which the function is well known and characterized. But there is also another type of RNA, so-called “circular RNA,” or circRNA, which forms a continuous loop that makes it more stable and less vulnerable to degradation. CircRNAs accumulate in the brain with age. Still, the biological functions of most circRNAs are not known and are a riddle for the scientific community. Now scientists from the Max Planck Institute for Biology of Aging have come one step closer to answer the question what these mysterious circRNAs do: one of them contributes to the aging process in fruit flies.

Carina Weigelt and other researchers in the group led by Linda Partridge, Director at the Max Planck Institute for Biology of Aging, used fruit flies to investigate the role of the circRNAs in the aging process. “This is unique, because it is not very well understood what circRNAs do, especially not in an aging perspective. Nobody has looked at circRNAs in a longevity context before,” says Carina Weigelt who conducted the main part of the study. She continues: “Now we have identified a circRNA that can extend lifespan of fruit flies when we increase it, and it is regulated by insulin signaling.”

Farmers have enough worries—between bad weather, rising costs, and shifting market demands—without having to stress about the carbon footprint of their operations. But now a new set of projects by scientists at Lawrence Berkeley National Laboratory (Berkeley Lab), including scientists at the Joint BioEnergy Institute (JBEI), could make agriculture both more sustainable and more profitable.

The three projects, funded by the U.S. Department of Energy (DOE), leverage Berkeley Lab’s strengths in artificial intelligence, sensors, and ecological biology. They aim to quantify and reduce the carbon intensity of agriculture, including the farming of biofuel feedstocks such as corn, soy, and sorghum, while also increasing yield.

Crop-based biofuels have the potential to supply up to about 5% of U.S. energy demand, according to the DOE. Two of the new projects are part of the SMARTFARM program of DOE’s Advanced Research Projects Agency-Energy (ARPA-E). This initiative aspires to make the biofuel supply chain carbon negative—meaning it removes or sequesters more carbon than it emits—which would greatly improve biofuel’s benefits to the broader economy and environment. Scientists also hope that the increased productivity will have the effect of lowering costs and increasing farmers’ income.

A team of researchers affiliated with several institutions in the U.S. has conducted an analysis of the system-wide costs and benefits of using engineered nanomaterials (ENMs) on crop-based agriculture. In their paper published in the journal Nature Nanotechnology, the group describes their analysis and what they found.

As scientists have come to realize that vast improvements in agricultural practices are needed if future generations are going to be able to grow enough food to feed the expected rise in population. They have increasingly turned to technology-based solutions, rather than just looking for biological advances. One such approach involves the design and use of ENMs on crops as a means of improving pest control and fertilizer efficiency. Prior research has shown that some ENMs can be mixed into the soil as a form of pest control or as a means of diverting fertilizer directly to the roots, reducing the amount required. In a similar vein, some prior research has shown that ENMs can be applied to parts of the plant above-ground as a means of pest control. What has been less well studied, the researchers note, is the overall impact of ENMs on crops and the environment.

To create artificial general intelligence, we need to study the brain.

:oooooo.

The battle of the sexes is a never-ending war waged within ourselves as male and female elements of our own bodies continually fight each other for supremacy. This is the astonishing implication of a pioneering study showing that it is possible to flick a genetic switch that turns female ovary cells into male testicular tissue.

For decades, the battle of the sexes has been accepted by biologists as a real phenomenon with males and females competing against each other — when their interests do not coincide — for the continued survival of their genes in the next generation. Now scientists have been able to show that a gender war is constantly raging between the genes and cells of one individual.

One of the great dogmas of biology is that gender is fixed from birth, determined by the inheritance of certain genes on the X and Y sex chromosomes. But this simplistic idea has been exploded by the latest study, which demonstrated that fully-developed adult females can undergo a partial sex change following a genetic modification to a single gene.

In other words, practicing the arts can be used to build capacity for managing one’s mental and emotional well-being.

Neuroesthetics — With recent advances in biological, cognitive, and neurological science, there are new forms of evidence on the arts and the brain. For example, researchers have used biofeedback to study the effects of visual art on neural circuits and neuroendocrine markers to find biological evidence that visual art promotes health, wellness, and fosters adaptive responses to stress.

Fascinating talk on a fun topic.

How does quantum logic differ from classical logic? How do we live in a universe that accommodates both?
Is it possible to observe quantum logic at work in our macroscopic world?
Surprisingly a little bit of quantum logic can disentangle some of our clumsy everyday conceptualisations of biology, language and culture.

Continue reading “Chris Guest — Quantum Logic & the Rise of the Memes” »