Lifeboat Foundation

The same process that eliminates replication errors also eliminates antiviral agents delivered by the treatments commonly used to fight other RNA viruses, such as HIV, HCV and Ebola virus, which partially explains why SARS-CoV-2 has proven so difficult to treat, Yang said.

The coronavirus that causes COVID-19 has demonstrated a stubborn ability to resist most nucleoside antiviral treatments, but a new study led by an Iowa State University scientist could help to overcome the virus’s defenses.

The study, published recently in the peer-reviewed journal Science, details the structure of a critical enzyme present in SARS-CoV-2, the coronavirus that causes COVID-19. This enzyme, known as the proofreading exoribonuclease (or ExoN), removes nucleoside antiviral medications from the virus’s RNA, rendering most nucleoside analogs-based antiviral treatments ineffective. The new study presents the atomic structures of the ExoN enzyme, which could lead to the development of new methods for deactivating the enzyme and opening the door to better treatments for patients suffering from COVID-19.

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This video explains introduction to molecular biology.

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Hundreds of genetic loci associated with age at menopause, combined with experimental evidence in mice, highlight mechanisms of reproductive ageing across the lifespan.

Modified RNA CRISPR boosts gene knockdown in human cells.

In the latest of ongoing efforts to expand technologies for modifying genes and their expression, researchers in the lab of Neville Sanjana, PhD, at the New York Genome Center (NYGC) and New York University (NYU) have developed chemically modified guide RNAs for a CRISPR system that targets RNA instead of DNA. These chemically-modified guide RNAs significantly enhance the ability to target – trace, edit, and/or knockdown – RNA in human cells.

Longevity. Technology: In the study published in Cell Chemical Biology, the research team explores a range of different RNA modifications and details how the modified guides increase efficiencies of CRISPR activity from 2-to 5-fold over unmodified guides. They also show that the optimised chemical modifications extend CRISPR targeting activity from 48 hours to four days.

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Researchers from Tokyo Metropolitan University have developed a new technology which allows non-contact manipulation of small objects using sound waves. They used a hemispherical array of ultrasound transducers to generate a 3D acoustic field that stably trapped and lifted a small polystyrene ball from a reflective surface. Their technique employs a method similar to laser trapping in biology, but adaptable to a wider range of particle sizes and materials.

The ability to move objects without touching them might sound like magic, but in the world of biology and chemistry, technology known as optical trapping has been helping scientists use light to move microscopic objects around for many years. In fact, half of the 2018 Nobel Prize for Physics, awarded to Arthur Ashkin (1922–2020) was in recognition of the remarkable achievements of this technology. But the use of laser light is not without its failings, particularly the limits placed on the properties of the objects which can be moved.

Enter acoustic trapping, an alternative that uses sound instead of optical waves. Sound waves may be applied to a wider range of object sizes and materials, and successful manipulation is now possible for millimeter-sized particles. Though they haven’t been around for as long as their optical counterparts, acoustic levitation and manipulation show exceptional promise for both lab settings and beyond. But the technical challenges that need to be surmounted are considerable. In particular, it is not easy to individually and accurately control vast arrays of ultrasound transducers in real time, or to get the right sound fields to lift objects far from the transducers themselves, particularly near surfaces that reflect sound.

Apigenin, quercetin, luteolin data: USDA Database for the Flavonoid.
Content of Selected Foods.
https://www.ars.usda.gov/arsuserfiles/80400525/data/flav/flav_r03-1.pdf.

Kuromanin data: http://phenol-explorer.eu/contents/polyphenol/9

Continue reading “Dietary CD38 Inhibitors: Are They Correlated With Biological Age?” »

Hemispherical array of ultrasound transducers lifts objects off reflective surfaces.

Researchers from Tokyo Metropolitan University have developed a new technology which allows non-contact manipulation of small objects using sound waves. They used a hemispherical array of ultrasound transducers to generate a 3D acoustic fields which stably trapped and lifted a small polystyrene ball from a reflective surface. Although their technique employs a method similar to laser trapping in biology, adaptable to a wider range of particle sizes and materials.

Continue reading “Acoustic Tweezers Can Pick Objects Up With Sound Waves – Without Any Physical Contact” »

An organic transistor that incorporates two bulk heterojunctions can exhibit active photoadaptation behaviour for light intensities that range over six orders of magnitude.

The development of artificial visual systems that mimic biological systems requires devices that can autonomously adapt their response to varying stimuli. However, emulating biological feedforward visual adaptation is challenging and requires complementary photoexcitation and inhibition, ideally in a single device. Here we show that an organic transistor that incorporates two bulk heterojunctions is capable of light intensity-dependent active photoadaptation. The approach couples the photovoltaic effect in bulk heterojunctions with electron trapping in the dielectric layer, allowing adaptive modulation of the carrier concentration of the transistor. Our device exhibits active photoadaptation behaviour for light intensities ranging over six orders of magnitude (1 to 106 cd m−2).

Circa 2012

Could biological systems have evolved to find the optimal quantum solutions to the problems thrown at them by nature? This Review presents an overview of the possible quantum effects seen in photosynthesis, avian magnetoreception and several other biological systems.