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“Prime Editing is a wonderful example of the revolution in genetic medicine that we are living through,” said Robert Nelsen, co-founder and Managing Director of ARCH Venture Partners, one of several companies to fund Prime Medicine. “Gene editing technologies like this, when mature, could totally change our conception of what’s possible in treating disease.”

“This is an opportunity to take a giant step toward cures for a much wider range of diseases than previously possible,” said Stephen Knight, President and Managing Partner of F-Prime Capital, another backer of the new company.

The funds raised will be used to continue building the company, expand the capabilities of its technology platform and rapidly advance towards clinical indications. By the end of 2021, Prime Medicine expects to employ more than 100 people full-time.

Investing in the convergence of bioelectrics & biologics for regeneration & healing — howard J. leonhardt, founder, leonhardt ventures.


Howard Leonhardt is the Founder of Leonhardt Ventures, the world’s first Innovation Accelerator focused on the convergence of bioelectrics & biologics for organ regeneration and tissue healing.

Howard is an accomplished inventor and serial entrepreneur, with 21 U.S. patents, over 100 patent claims for products for treating cardiovascular disease, and has over 40 new patent claims pending. His TALENT (Taheri-Leonhardt) stent graft, developed in the early 1990′s, holds a leading world market share for repairing aortic aneurysms without surgery.

University of California San Diego scientists have now developed several genetic editing tools that help pave the way to an eventual gene drive designed to stop Culex mosquitoes from spreading disease. Gene drives are designed to spread modified genes, in this case those that disable the ability to transmit pathogens, throughout the targeted wild population.


Genetics toolkit targets less researched Culex mosquitoes, which transmit West Nile virus and avian malaria.

Since the onset of the CRISPR genetic editing revolution, scientists have been working to leverage the technology in the development of gene drives that target pathogen-spreading mosquitoes such as Anopheles and Aedes species, which spread malaria, dengue, and other life-threatening diseases.

Breast cancer is the leading cause of cancer death in women around the world, responsible for 1700 deaths every day. Although the vast majority of breast cancers are treatable, the most aggressive subtype—triple negative breast cancer (TNBC) – has a high recurrence rate, a high potential for metastasis and shows resistance to conventional treatments, leading to very poor prognosis and survival outcomes. A team of researchers at the Research Institute of the McGill University Health Center (RI-MUHC) conducted a preclinical study and discovered a novel targeted combination therapy that efficiently reduced tumor growth in metastatic breast cancer. Published in Nature Communications, their findings could lead to the development of a novel first line targeted therapy for the treatment of TNBC, with the prospect of rapidly transitioning to clinical trials in humans.

“There is no targeted therapy for TNBC. Chemotherapy treatment can even enrich these tumors in and be detrimental to the patient, as we have shown in a previous study,” says Dr. Jean-Jacques Lebrun, senior scientist in the Cancer Research Program at the RI-MUHC and principal investigator of the study. “Filling that huge medical gap was our motivation in conducting this study.”

While most breast cancers have one of three main receptors that are like entrance gates for treatments—estrogen, progesterone and a protein called human epidermal growth factor (HER2) – TNBC has none, thus the name triple negative . Using state-of-the-art technologies such as and genome-wide molecular approaches, the team identified two pathways which could be targeted in a therapeutic strategy.

“Once the virus is recognised, the CRISPR enzyme is activated and chops up the virus,” she said.


Paris (AFP)

Scientists have used CRISPR gene-editing technology to successfully block the transmission of the SARS-CoV-2 virus in infected human cells, according to research released Tuesday that could pave the way for Covid-19 treatments.

Writing in the journal Nature Communications, researchers in Australia said the tool was effective against viral transmissions in lab tests, adding that they hoped to begin animal trials soon.

Circa 2019


MIT’S new mini cheetah robot is the first four-legged robot to do a backflip. At only 20 pounds the limber quadruped can bend and swing its legs wide, enabling it to walk either right side up or upside down. The robot can also trot over uneven terrain about twice as fast as an average person’s walking speed. (Learn more: http://news.mit.edu/2019/mit-mini-cheetah-first-four-legged-…kflip-0304)

Watch more videos from MIT: https://www.youtube.com/user/MITNewsOffice?sub_confirmation=1

The innovative material that creates green energy through mechanical force.

A new nanotechnology development by an international research team led by Tel Aviv University researchers will make it possible to generate electric currents and voltage within the human body through the activation of various organs (mechanical force). The researchers explain that the development involves a new and very strong biological material, similar to collagen, which is non-toxic and causes no harm to the body’s tissues. The researchers believe that this new nanotechnology has many potential applications in medicine, including harvesting clean energy to operate devices implanted in the body (such as pacemakers) through the body’s natural movements, eliminating the need for batteries.

The study was led by Prof. Ehud Gazit of the Shmunis School of Biomedicine and Cancer Research at the Wise Faculty of Life Sciences, the Department of Materials Science and Engineering at the Fleischman Faculty of Engineering, and the Center for Nanoscience and Nanotechnology, along with his lab team, Dr. Santu Bera and Dr. Wei Ji.

The researchers explain that the development involves a new and very strong biological material, similar to collagen, which is non-toxic and causes no harm to the body’s tissues. The researchers believe that this new nanotechnology has many potential applications in medicine, including harvesting clean energy to operate devices implanted in the body (such as pacemakers) through the body’s natural movements, eliminating the need for batteries.


The study was led by Prof. Ehud Gazit of the Shmunis School of Biomedicine and Cancer Research at the Wise Faculty of Life Sciences, the Department of Materials Science and Engineering at the Fleischman Faculty of Engineering and the Center for Nanoscience and Nanotechnology, along with his lab team, Dr. Santu Bera and Dr. Wei Ji.

Also taking part in the study were researchers from the Weizmann Institute and a number of research institutes in Ireland, China and Australia. As a result of their findings, the researchers received two ERC-POC grants aimed at using the scientific research from the ERC grant that Gazit had previously won for applied technology. The research was published in the prestigious journal Nature Communications.

Prof. Gazit, who is also Founding Director of the Blavatnik Center for Drug Discovery, explains: Collagen is the most prevalent protein in the human body, constituting about 30% of all of the proteins in our body. It is a biological material with a helical structure and a variety of important physical properties, such as mechanical strength and flexibility, which are useful in many applications. However, because the collagen molecule itself is large and complex, researchers have long been looking for a minimalistic, short and simple molecule that is based on collagen and exhibits similar properties. About a year and a half ago, in the journal Nature Materials, our group published a study in which we used nanotechnological means to engineer a new biological material that meets these requirements.