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Category: bioengineering – Page 80

The world’s smallest life form can now move, thanks to genetic engineering

In a breakthrough study, Japanese researchers at Osaka Metropolitan University have engineered the smallest motile life form ever. They introduced seven bacterial proteins into a synthetic bacterium, allowing it to move independently.

The rise of synthetic biology.

The new study is based on the synthetic bacterium called syn-3. The tiny spherical bacteria contain minimal genetic information, allowing them to grow and divide without motility.

The team experimented with syn-3 by introducing seven genes that code for proteins that are likely involved in the swimming motion of Spiroplasma bacteria.

UA/Wikimedia Commons.

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Nano-magnets can be used to restore damaged nerve cells —Bar-Ilan

These fundamental units of the brain and nervous system – composed of the cell body, the dendrites and the axon (a long, thin extension responsible for communicating with other cells) – receive sensory input from the external world, send motor commands to our muscles and for transform and relay the electrical signals at every step in between.

“Our novel method of creating ‘mini-brains’ opens the door to finding solutions for various neurological impairments”

Prof. Orit Shefi and doctoral student Reut Plen from the Kofkin Faculty of Engineering at Bar-Ilan University (BIU) have developed a novel technique to overcome this challenge using nanotechnology and magnetic manipulations – one of the most innovative approaches to creating neural networks. Their research was recently published in the peer-reviewed journal Advanced Functional Materials under the title “Bioengineering 3D Neural Networks Using Magnetic Manipulations.”

What Will Happen After The Technological Singularity? — Ray Kurzweil

Ray Kurzweil is an author, computer scientist, inventor, futurist and a director of engineering at Google. Kurzweil is a public advocate for the futurist and transhumanist movements, and gives public talks to share his optimistic outlook on life extension technologies and the future of nanotechnology, robotics, and biotechnology.

Recorded 2013

The Failures and Opportunities of Immortality

Steven Parton [00:00:37] Hello everyone. My name is Steven Parton and you are listening to the feedback loop on Singularity Radio. This week our guest is business and technology reporter Peter Ward. Earlier this year, Peter released his book The Price of Immortality The Race to Live Forever, where he investigates the many movements and organizations that are seeking to increase the human lifespan from the Church of Perpetual Life in Florida to some of the biggest tech giants in Silicon Valley. In this episode, we explore Peter’s findings, which takes us on a tour from cryogenics to mind uploading from supplements to gene editing and much more. Along the way, we discuss the details of how one might actually achieve immortality, talking about senescent cells and telomeres. Discussing whether it’s better to live healthy than to live long. We also discuss the scams and failures that seem to dominate the longevity space, as well as the efforts that seem the most promising. And now, since we’re on the topic of discussing how precious life is, are waste no more of your precious time? So everyone, please welcome to the feedback loop. Peter Ward. Well then, Peter, thanks for joining me. I think the best place to start is in April of this year. You released a book called The Price of Immortality The Race to Live Forever and where I love to start with anyone who’s written a book is just hearing about your motivations for the book. Why did you decide that this was a topic worth exploring?

The Formula of Immortality

Dreaming about Immortality has a long history, almost as long as the failed quests to achieve it. And during all these years and years, the solutions for achieving immortality can fall in several categories. The first is to take some kind of “magic pill” – be it the fountain of youth, the elixir of life, the holy grail, till modern medicine of genetic engineering. After the magic “pills” proved to be a failure, the second attempt was through more creative endeavours, such as building a monastery, a temple, making a sculpture or painting, till nowadays when we talk about digital immortality and I guess soon about virtual immortality. And, of course, there were always the “party-spoilers”, the ones asking: why to be Immortal?

Humanity has changed in many ways, but the hope of the dream of Immortality remained and generation after generation, trying to find it in different ways or forms. So, keep with us as we travel alongside the deepest human dream, to see all (the failed) trials.

Researchers use AI to assess patients’ vocals after surgery on the larynx

Artificial intelligence would be used to detect changes in the vocals of each patient after a laryngectomy.

Researchers from Kaunas University of Technology Faculty of Informatics (KTU IF) and Lithuanian University of Health Sciences (LSMU) in Lithuania have created a new substitute voice evaluation index that can detect pathologies in patients’ voices more quickly and efficiently. Voice pathologies include a variety of disorders such as growths on the vocal cords, spasms, swelling or paralysis in the vocal cords.

AI could be used to determine changes in voice after laryngectomy.

Laryngectomy is a surgery that requires the removal of the larynx.

Simarik/iStock.

“For some, the voice changes only slightly, while for others, it can be a life-changing situation. Imagine calling someone on the phone, emergency services, police, etc. – and the one you’re calling does not understand anything. Or even not hear you – as the phone’s noise removal system will cut it out,” said Dr. Rytis Maskeliunas, professor with the Department of Multimedia Engineering, Faculty of Informatics and chief researcher at Kaunas University of Technology Faculty of Informatics.

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Engineered nanoparticles can help phytoplankton kidnap the excess CO2 on Earth

The solution to our carbon problem is floating in the oceans.

Phytoplankton are microscopic organisms (can be bacteria, algae, or plants) that perform photosynthesis in oceans and eliminate excess carbon dioxide from Earth’s atmosphere. They sequester about 40 percent of the total carbon produced every year globally and, therefore, also play a major role in mitigating global warming.

A team of researchers from the Pacific Northwest National Laboratory (PNNL) has proposed that by feeding engineered nanoparticles (ENPs) as fertilizers to phytoplankton. Humans can increase the growth of these microorganisms in oceans and eventually fix more CO2 from Earth than ever.

Thousands of phages found to have CRISPR gene editing system

A team of researchers at the University of California, Berkeley, and University of California, Los Angeles, working with a colleague from Vilnius University, has found evidence of thousands of phages with DNA strands that should allow them to conduct gene editing on other viruses or bacteria. Their paper has been published in the open-access journal Cell.

In 2012, some of the researchers on this same team discovered that CRISPR-Cas9 could be programmed using RNA to edit targeted DNA strands from other organisms (and won a Nobel prize for it). Their work emerged from findings that many types of use CRISPR-Cas systems to defend against viral attacks. Using such systems, bacteria can cut and remove strands of DNA from and store them in their own genomes to combat the same viral strain should it attack again.

Since that time, researchers have found that some viruses have similar machinery, but it was deemed to be rare. In this new effort, the researchers sought to determine actual prevalence.

Predicting the Structures of Proteins

Kathryn Tunyasuvunakool grew up surrounded by scientific activities carried out at home by her mother—who went to university a few years after Tunyasuvunakool was born. One day a pendulum hung from a ceiling in her family’s home, Tunyasuvunakool’s mother standing next to it, timing the swings for a science assignment. Another day, fossil samples littered the dining table, her mother scrutinizing their patterns for a report. This early exposure to science imbued Tunyasuvunakool with the idea that science was fun and that having a career in science was an attainable goal. “From early on I was desperate to go to university and be a scientist,” she says.

Tunyasuvunakool fulfilled that ambition, studying math as an undergraduate, and computational biology as a graduate student. During her PhD work she helped create a model that captured various elements of the development of a soil-inhabiting roundworm called Caenorhabditis elegans, a popular organism for both biologists and physicists to study. She also developed a love for programming, which, she says, lent itself naturally to a jump into software engineering. Today Tunyasuvunakool is part of the team behind DeepMind’s AlphaFold—a protein-structure-prediction tool. Physics Magazine spoke to her to find out more about this software, which recently won two of its makers a Breakthrough Prize, and about why she’s excited for the potential discoveries it could enable.

All interviews are edited for brevity and clarity.