In a first-of-its-kind clinical trial, a human has received a 3D-bioprinted ear implant grown from the patient’s own living cells – thanks to a technology platform developed by a Cornellian-founded startup company.
This bioengineered breakthrough has the potential to significantly improve the lives of the approximately 1,500 children who are born annually in the U.S. with microtia, a congenital ear deformity. The approach could eventually lead to tissue implants for treating other conditions and traumatic injuries, reconstructive and regenerative therapy, and possibly even the biomanufacture of whole organs.
The company, 3DBio Therapeutics, was founded in 2014 by Dan Cohen ‘04, M.S. ‘07, Ph.D. ‘10, along with Lawrence Bonassar, the Daljit S. and Elaine Sarkaria Professor in Biomedical Engineering and in Mechanical and Aerospace Engineering in the College of Engineering, and Hod Lipson, who taught at Cornell for 14 years and is now a professor at Columbia University.
MSM and Experts fail to see the logic in how Elon Musk is taking over Twitter. They think it’s chaos, a mess, he’s out of his depth. But Elon is just working AGILE, and AGILE always seems like a mess to onlookers used to traditional work! The video describes Elon’s Agile Takeover of Twitter and shows the opportunity worth BILLION$ that Elon Musk has ALREADY unlocked.
In the piece I explore some of the emerging tech that will impact our coming year. Thank you for reading and sharing!
2022 was a transformative year for technological innovation and digital transformation. The trend will continue as the pace of innovation and development of potentially disruptive emerging technologies exponentially increases every year. The question arises, what lies ahead for tech for us to learn and experience in 2023?
While there are many impactful tech topics such as the Internet of Things, 5G, Space, Genomics, Synthetic Biology, Automation, Augmented Reality, and others, there are four tech areas to keep a keen watch on this coming year as they have promising and near-term capabilities to transform lives. They include: 1) artificial intelligence, 2) computing technologies, 3) robotics, and 4) materials science.
In the underground movement known as, people are taking their health into their own hands. Biohacking ranges from people making simple lifestyle changes to extreme body modifications.
One popular form of focuses on nutrigenomics, where biohackers study how the foods they eat affect their genes over time. They believe they can map and track the way their diet affects genetic function. They use dietary restrictions and blood tests, while tracking their moods, energy levels, behaviors, and cognitive abilities.
Then there are grinders, a subculture of A grinder believes there’s a hack for every part of the body. Rather than attempting to modify our existing biology, grinders seek to enhance it with implanted technology.
An international research team led by Dr. Ana Guadaño at the Alberto Sols Biomedical Research Institute (IIBM, a combined CSIC-UAM center) and involving the Complutense University of Madrid (UCM), used CRISPR gene editing techniques to incorporate into mice a mutation of the MCT8 protein responsible for transporting thyroid hormones to the interior of the cell.
Patients with mutations in this protein suffer from Allan-Herndon-Dudley syndrome, a rare disease that takes the form of serious neurological alterations, in which each patient may reveal a different mutation of MCT8.
This study, published in Neurobiology of Disease, describes the first avatar model for the disease—in other words, the first animal model with the same genetic alteration as various patients.
These genetically engineered plants can take over the work of 30 houseplants.
A bioengineered plant is able to clean the air by doing the work of over 30 houseplantsIt could be the start of a bold new industry that develps over the next 15 to 20 years.
The Neo P1 is the first of its kind.
A startup in Paris has developed a plant that could take over the work of 30 houseplants — and it’s just the beginning.
Yuri_Arcurs/iStock.
Neo P1, effectively a super-efficient air purifier, can metabolize four major indoor air pollutants and absorb certain volatile organic compounds, or VOCs. It’s the start of a revolution in plants that could lead to a dramatic new industry.
Discusses the possibility of Femtotech and the technological possibilities it may unlock. Not long ago nanotechnology was a fringe topic; now it’s a flourishing engineering field, and fairly mainstream. For example, while writing this article, I happened to receive an email advertisement for the “Second World Conference on Nanomedicine and Drug Delivery,” in Kerala, India. It wasn’t so long ago that nanomedicine seemed merely a flicker in the eyes of Robert Freitas and a few other visionaries!
But nano is not as small as the world goes. A nanometer is 10–9 meters – the scale of atoms and molecules. A water molecule is a bit less than one nanometer long, and a germ is around a thousand nanometers across. On the other hand, a proton has a diameter of a couple femtometers – where a femtometer, at 10–15 meters, makes a nanometer seem positively gargantuan. Now that the viability of nanotech is widely accepted (in spite of some ongoing heated debates about the details), it’s time to ask: what about femtotech? Picotech or other technologies at the scales between nano and femto seem relatively uninteresting, because we don’t know any basic constituents of matter that exist at those scales. But femtotech, based on engineering structures from subatomic particles, makes perfect conceptual sense, though it’s certainly difficult given current technology.
The nanotech field was arguably launched by Richard Feynman’s 1959 talk “There’s Plenty of Room at the Bottom.” As Feynman wrote there.
“It is a staggeringly small world that is below. In the year 2000, when they look back at this age, they will wonder why it was not until the year 1960 that anybody began seriously to move in this direction.
Why cannot we write the entire 24 volumes of the Encyclopedia Brittanica on the head of a pin? ”
Bio: Hugo de Garis (born 1947, Sydney, Australia) is a researcher in the sub-field of artificial intelligence (AI) known as evolvable hardware. He became known in the 1990s for his research on the use of genetic algorithms to evolve neural networks using three dimensional cellular automata inside field programmable gate arrays. He claimed that this approach would enable the creation of what he terms “artificial brains” which would quickly surpass human levels of intelligence.
Highly active antiretroviral therapy (HAART) successfully suppresses human immunodeficiency virus (HIV) replication and improves the quality of life of patients living with HIV. However, current HAART does not eradicate HIV infection because an HIV reservoir is established in latently infected cells and is not recognized by the immune system. The successful curative treatment of the Berlin and London patients following bone marrow transplantation inspired researchers to identify an approach for the functional cure of HIV. As a promising technology, gene editing-based strategies have attracted considerable attention and sparked much debate. Herein, we discuss the development of different gene editing strategies in the functional cure of HIV and highlight the potential for clinical applications prospects. Graphical Abstract.
For millennia, humans have been harnessing #microbes to produce everything from breads, to cheeses, to alcohol. Now these tiny organisms have produced another powerful revolution — the gene editing tool CRISPR. Rodolphe Barrangou, Ph.D., was working at the food company Danisco, where he was trying to produce yogurt lines resistant to contamination. In a series of groundbreaking experiments, he helped uncover what CRISPR was, how it worked, and why it could be so transformative.
Speaker Biography: Rodolphe Barrangou, Ph.D., studies beneficial microbes, focusing on the occurrence and diversity of lactic acid bacteria in fermented foods and as probiotics. Using functional genomics, he has focused on uncovering the genetic basis for health-promoting traits, including the ability to uptake and catabolize non-digestible carbohydrates. He spent 9 years at Danisco-DuPont, characterizing probiotics and starter cultures, and established the functional role of CRISPR-Cas as adaptive immune systems in bacteria. At NC State, he continues to study the molecular basis for their mechanism of action, as well as developing and applying CRISPR-based technologies for genotyping, building immunity and genome editing.
Producers: Sarah Goodwin, Rebecca Ellsworth. Cinematographer: Derek Reich. Editor: Rebecca Ellsworth\ Graphics: Chris George, Maggie Hubbard. Assistant Camera: Gray McClamrock. Drone aerials: Travis Jack. Supervising Editor: Regina Sobel. Field Producer: Meredith DeSalazar. Interview by: Adam Bolt. Associate Producer: Shelley Elizabeth Carter. Executive Producers: Shannon Behrman, Sarah Goodwin, Elliot Kirschner.
