A newly developed material has been used to create a gel capable of repairing and rebuilding tooth enamel, offering a potential breakthrough in both preventive and restorative dental care.
This protein-based gel, which contains no fluoride, can be quickly applied to teeth using the same method dentists use for traditional fluoride treatments. It imitates the natural proteins responsible for guiding enamel formation early in life. Once in place, the gel forms a thin, durable coating that seeps into the tooth surface, filling small cracks and imperfections.
A new 3D human brain tissue platform developed by MIT researchers is the first to integrate all major brain cell types, including neurons, glial cells, and the vasculature, into a single culture.
Grown from individual donors’ induced pluripotent stem cells, these models — dubbed Multicellular Integrated Brains (miBrains) — replicate key features and functions of human brain tissue, are readily customizable through gene editing, and can be produced in quantities that support large-scale research.
Although each unit is smaller than a dime, miBrains may be worth a great deal to researchers and drug developers who need more complex living lab models to better understand brain biology and treat diseases.
Researchers from Nobel Laureate David Baker’s lab and the University of Washington’s Institute for Protein Design (IPD) have used artificial intelligence to design antibodies from scratch — notching another game-changing breakthrough for the scientists and their field of research.
“It was really a grand challenge — a pipe dream,” said Andrew Borst, head of electron microscopy R&D at IPD. Now that they’ve hit the milestone of engineering antibodies that successfully bind to their targets, the research “can go on and it can grow to heights that you can’t imagine right now.”
Borst and his colleagues are publishing their work in the peer-reviewed journal Nature. The development could supercharge the $200 billion antibody drug industry.
Scientists have developed a nanoparticle-based treatment that successfully reversed Alzheimer’s disease in mice.
As detailed in a new paper published in the journal Signal Transduction and Targeted Therapy, the team co-led by the Institute for Bioengineering of Catalonia, Spain (IBEC), and West China Hospital, Sichuan University, developed bioactive “supramolecular drugs” that can proactively repair the blood-brain barrier.
The barrier plays an important role in the health of the brain, defending it from harmful substances and other pathogens. Alzheimer’s has been linked to a weakening of the barrier’s integrity, allowing for impairing toxins to make it through.
Chimeric Antigen Receptor (CAR) T cell therapies have revolutionized cancer treatment—but so far, their success has been largely limited to blood cancers. Solid tumors, which account for around 90% of all adult cancers, remain a major challenge because they are difficult for CAR T cells to infiltrate and are often highly heterogeneous, making them harder to target with a single therapy.
Researchers at Monash University, in collaboration with scientists from the Peter MacCallum Cancer Center, used CRISPR-based gene editing or a PTPN2 inhibitor to enhance the function of human CAR T cells engineered to recognize an antigen expressed on many solid tumors.
The study, led by Professor Tony Tiganis and Dr. Florian Wiede, was published in Science Translational Medicine.
Researchers at the University of Warwick have created a straightforward new way to predict how irregularly shaped nanoparticles, a harmful type of airborne pollutant, move through the air.
Each day, people inhale countless microscopic particles such as soot, dust, pollen, microplastics, viruses, and engineered nanoparticles. Many of these particles are so small that they can reach deep into the lungs and even pass into the bloodstream, where they may contribute to serious health problems including heart disease, stroke, and cancer.
While most airborne particles have uneven shapes, existing mathematical models often treat them as perfect spheres because that makes the equations easier to handle. This simplification limits scientists’ ability to accurately describe or track how real, non-spherical particles move, especially those that are more dangerous.
What happens when the pursuit of perfection forgets compassion? SCP-191, known as The Cyborg Child, is one of the most haunting examples of speculative bioengineering ever documented. This essay examines the anatomy, psychology, and philosophy of a child transformed into a machine — a being caught between humanity and technology.
In this episode, we explore:
How cybernetic modification redefines the human body.
The science behind hybrid consciousness and neural integration.
Chloroplasts—the “light power plants” of plant cells—are increasingly the focus of synthetic biology. These organelles house the photosynthetic apparatus and host several metabolic pathways that are of great interest for engineering new traits. Gene insertion into chloroplasts is precise and carries a lower risk of transgene escape.
Despite this potential, chloroplast biotechnology remains in its infancy because standardized, scalable methods for rapid testing of diverse genetic parts have been missing. A research team from the Max Planck Institute for Terrestrial Microbiology in Marburg has now presented a micro‑algal platform that allows automated, fast, and large‑scale testing of chloroplast genetic modifications.
The study is published in the journal Nature Plants.
Age Reversal in Primates has been achieved. We have it now.
Anti-aging gene therapy, stem cell rejuvenation, and FOXO3 longevity research take center stage in this episode of Longevity Science News with Emmett Short. This groundbreaking study out of Beijing shows that gene-edited human stem cells—specifically FOXO3-enhanced senescence-resistant mesenchymal progenitor cells (SRCs)—can reverse biological aging in elderly monkeys, restoring youthful brain structure, bone density, immune strength, and even ovarian function. By upgrading the FOXO3 longevity gene, scientists created stem cells that resist cellular senescence, DNA damage, and oxidative stress, effectively making the monkeys younger from the inside out. MRI scans revealed increased cortical thickness and improved memory-related connectivity, while biological age clocks showed a 3–5 year reversal across 54% of tissues—equivalent to 9–15 years of human rejuvenation. Emmett explains how these anti-aging stem cells, epigenetic resets, and exosome-based rejuvenation pathways could revolutionize regenerative medicine, longevity biotech, and future human trials. He also explores the costs, ethics, and long-term implications of turning back time at the cellular level. If you’re passionate about biohacking, gene editing, lifespan extension, or the future of anti-aging science, this is the video for you.
3.3). This produces a fragment, the F(ab′)2fragment, in which the two antigen-binding arms of the antibody molecule remain linked. In this case the remaining part of the heavy chain is cut into several small fragments. The F(ab′)2 fragment has exactly the same antigen-binding characteristics as the original antibody but is unable to interact with any effector molecule. It is thus of potential value in therapeutic applications of antibodies as well as in research into the functional role of the Fc portion.
Genetic engineering techniques also now permit the construction of many different antibody-related molecules. One important type is a truncated Fab comprising only the V domain of a heavy chain linked by a stretch of synthetic peptide to a V domain of a light chain. This is called single-chain Fv, named from Fragment v ariable. Fv molecules may become valuable therapeutic agents because of their small size, which allows them to penetrate tissues readily. They can be coupled to protein toxins to yield immunotoxins with potential application, for example, in tumor therapy in the case of a Fv specific for a tumor antigen (see Chapter 14).
