Archive for the ‘bioengineering’ category: Page 6

Apr 3, 2022

Scientists Create Synthetic Organisms That Can Reproduce

Posted by in categories: bioengineering, biological, information science

Scientists have created synthetic organisms that can self-replicate. Known as “Xenobots,” these tiny millimeter-wide biological machines now have the ability to reproduce — a striking leap forward in synthetic biology.

Published in the Proceedings of the National Academy of Sciences 0, a joint team from the University of Vermont, Tufts University, and Harvard University used Xenopus laevis frog embryonic cells to construct the Xenobots.

Their original work began in 2020 when the Xenobots were first “built.” The team designed an algorithm that assembled countless cells together to construct various biological machines, eventually settling on embryonic skin cells from frogs.

Mar 31, 2022

Battery breakthrough doubles lifespan of electric car batteries

Posted by in categories: bioengineering, computing, nanotechnology, sustainability, transportation

Engineers have discovered a way to more than double the lifespan of batteries used in smartphones and electric cars.

The battery breakthrough was successfully demonstrated by researchers at the University of Queensland in Australia, who increased the lifespan of a lithium-ion (li-ion) battery from several hundred charge/ discharge cycles, to more than 1,000.

“Our process will increase the lifespan of batteries in many things, from smartphones and laptops, to power tools and electric vehicles,” said Professor Lianzhou Wang from the Australian Institute for Bioengineering and Nanotechnology.

Mar 30, 2022

The Potential of CRISPR/Cas9 Gene Editing as a Treatment Strategy for Alzheimer’s Disease

Posted by in categories: bioengineering, biotech/medical, health, neuroscience

Despite a wealth of knowledge gained in the past three decades concerning the molecular underpinnings of Alzheimer’s disease (AD), progress towards obtaining effective, disease modifying therapies has proven to be challenging. In this manner, numerous clinical trials targeting the production, aggregation, and toxicity of beta-amyloid, have failed to meet efficacy standards. This puts into question the beta-amyloid hypothesis and suggests that additional treatment strategies should be explored. The recent emergence of CRISPR/Cas9 gene editing as a relatively straightforward, inexpensive, and precise system has led to an increased interest of applying this technique in AD. CRISPR/Cas9 gene editing can be used as a direct treatment approach or to help establish better animal models that more faithfully mimic human neurodegenerative diseases. In this manner, this technique has already shown promise in other neurological disorders, such as Huntington’s disease. The purpose of this review is to examine the potential utility of CRISPR/Cas9 as a treatment option for AD by targeting specific genes including those that cause early-onset AD, as well as those that are significant risk factors for late-onset AD such as the apolipoprotein E4 (APOE4) gene.

Keywords: Alzheimer’s disease, CRISPR/Cas9, Gene editing, Treatment, Huntington’s disease, iPSC neurons.

Alzheimer’s Disease (AD) is a progressive and fatal neurodegenerative disorder that primarily affects older adults and is the most common cause of dementia [1]. Currently it afflicts 5.5 million Americans and that number is expected to triple by 2050. At the present time, it is the third leading cause of death behind heart disease and cancer, with an estimated 700,000 Americans ages65 years will have AD when they die [2]. In addition, the cost of the disease is substantial with $259 billion health care dollars going to manage the disease currently, and by the middle of the century costs are predicted to soar over $1.2 trillion, which will completely bankrupt the healthcare system in the USA [3]. Worldwide, 47 million people live with dementia and that number is projected to increase to more than 131 million by 2050 with an estimated worldwide cost of US $818 billion [4].

Mar 23, 2022

Gene Editing Now Has A Next-Generation CRISPR Tool

Posted by in categories: bioengineering, biotech/medical, evolution

The creation of new proteins and peptides for use with CRISPR represents the next stage in the evolution of this technology.

Mar 20, 2022

Janice Chen, Nathan Chen’s sister, is building a $100 billion CRISPR gene editing company

Posted by in categories: bioengineering, biotech/medical, chemistry, government

Janice Chen, Ph.D., one of Olympic gold medalist Nathan Chen’s siblings, is on a mission to build a $100 billion biotech company.

In 2018, she co-founded Mammoth Biosciences with Trevor Martin, Lucas Harrington and Jennifer Doudna 0, who won the Nobel Prize in Chemistry two years later for her pioneering work in CRISPR gene editing. Doudna also served as Chen’s mentor while she pursued her doctorate degree in molecular and cell biology at the University of California at Berkeley.

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Mar 19, 2022

You’re invited to join our subreddit community —

Posted by in categories: bioengineering, biotech/medical, cyborgs, genetics, nanotechnology, robotics/AI, singularity, transhumanism, virtual reality

R/IntelligenceSupernova — dedicated to techno-optimists, singularitarians, transhumanist thinkers, cosmists, futurists, AI researchers, cyberneticists, crypto enthusiasts, VR creators, artists, philosophers of mind. Accelerating now towards the Cybernetic Singularity with unprecedented advances in AI & Cybernetics, VR, Biotechnology, Nanotechnology, Bionics, Genetic Engineering, Optogenetics, Neuroengineering, Robotics, and other IT fields.

Join now:

#Subreddit #IntelligenceSupernova

Mar 17, 2022

The End of Ageing with Michael Greve

Posted by in categories: bioengineering, biotech/medical, life extension

A big thank you to the Nonconventional podcast and fabulous host Ela Crain for our in-depth conversation.

Listen to this episode from Nonconventional Show on Spotify. Michael Greve, founder and CEO of the anti-ageing non-profit, Forever Healthy, discusses how biohacking will help eradicate age-related diseases through rejuvenation therapies and nutritional optimisation. He also highlights the societal impact longer lives will have on the world. Michael talks about how his origins as a highly successful internet entrepreneur have led him to fund people-focused startups and to tackle the question of longevity through new and alternative healthcare technologies. *** Join Ela Crain as she interviews inspiring guests from all walks of life. Leave a review and follow us to stay up-to-date with the latest episodes. Watch the video version on the Nonconventional Youtube channel. Find out more about the Nonconventional Show on our: | Website — nonconventional.

Mar 17, 2022

The End of Ageing with Michael Greve | Nonconventional Podcast [EP 9]

Posted by in categories: bioengineering, biotech/medical, life extension

The Nonconventional show published the video version of yesterday’s Forever Healthy episode.

Join the team:

Continue reading “The End of Ageing with Michael Greve | Nonconventional Podcast [EP 9]” »

Mar 16, 2022

Bacterial enzyme that copies DNA might make more mistakes in zero gravity

Posted by in categories: bioengineering, biotech/medical

(Inside Science) — An enzyme in the bacterium E. coli made more errors copying synthetic DNA when exposed to zero gravity than the same enzyme did in normal gravity, a recent study finds.

The paper raises the possibility that some enzymes work differently in space compared to on Earth. “It gives us an idea that enzymes, like polymerases or others that are involved in maintaining the integrity of our DNA, may be influenced by spaceflight,” said Susan Bailey, a radiation cancer biologist at Colorado State University in Fort Collins who has studied DNA damage caused by space radiation and did not contribute to the new paper.

Aaron Rosenstein, lead author of the paper and a bioengineering graduate student at the University of Toronto, said the finding “warrants further investigation into other enzymes that are involved in crucial pathways that are inherent to life and survival.”

Continue reading “Bacterial enzyme that copies DNA might make more mistakes in zero gravity” »

Mar 16, 2022

A talk by David Pearce for the Stepping into the Future conference 2022

Posted by in categories: bioengineering, biotech/medical, evolution, health, neuroscience, transhumanism

Synopsis: No sentient being in the evolutionary history of life has enjoyed good health as defined by the World Health Organization. The founding constitution of the World Health Organization commits the international community to a daringly ambitious conception of health: “a state of complete physical, mental and social wellbeing”. Health as so conceived is inconsistent with evolution via natural selection. Lifelong good health is inconsistent with a Darwinian genome. Indeed, the vision of the World Health Organization evokes the World Transhumanist Association. Transhumanists aspire to a civilization of superhappiness, superlongevity and superintelligence; but even an architecture of mind based on information-sensitive gradients of bliss cannot yield complete well-being. Post-Darwinian life will be sublime, but “complete” well-being is posthuman – more akin to Buddhist nirvana. So the aim of this talk is twofold. First, I shall explore the therapeutic interventions needed to underwrite the WHO conception of good health for everyone – or rather, a recognisable approximation of lifelong good health. What genes, allelic combinations and metabolic pathways must be targeted to deliver a biohappiness revolution: life based entirely on gradients of well-being? How can we devise a more civilized signalling system for human and nonhuman animal life than gradients of mental and physical pain? Secondly, how can genome reformists shift the Overton window of political discourse in favour of hedonic uplift? How can prospective parents worldwide – and the World Health Organization – be encouraged to embrace genome reform? For only germline engineering can fix the problem of suffering and create a happy biosphere for all sentient beings.…id-pearce/

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