Lifeboat Foundation

A new potential method to administer gene therapy without triggering an immune response.

Scientists at Stanford University School of Medicine managed to administer effective gene therapy in mice without triggering an autoimmune reaction. The research, led by Dr. Peggy Ho, Ph.D., was published in the Proceedings of the National Academy of Sciences [1].

Study abstract

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https://speaker.future.consulting/en/home/search/video/video…re-cancer/

“Lego block” artificial cells that can kill bacteria have been created by researchers at the University of California, Davis Department of Biomedical Engineering. The work is reported Aug. 29 in the journal ACS Applied Materials & Interfaces.

“We engineered artificial cells from the bottom-up – like Lego blocks – to destroy bacteria,” said Assistant Professor Cheemeng Tan, who led the work. The cells are built from liposomes, or bubbles with a cell-like lipid membrane, and purified cellular components including proteins, DNA and metabolites.

“We demonstrated that artificial cells can sense, react and interact with bacteria, as well as function as systems that both detect and kill bacteria with little dependence on their environment,” Tan said.

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Researchers at the Wyss Institute were successful in engineering different species of bacteria that can talk to each other.

Gene editing halted the progression of Duchenne’s muscular dystrophy in dogs.

A team of researchers in China has used a form of the CRISPR gene editing technique to repair a genetic defect in a viable human embryo. In their paper published in the journal Molecular Therapy, the group describes their work and how well it worked.

Only three years ago, CRISPR was first used on a human embryo. In that work, a Chinese team attempted to use the technique to repair a genetic fault. Though the work made headlines around the world, it had a low success rate—just four out of 54 embryos that survived the technique carried the repaired genes. Since that time, a new variation of CRISPR has been developed—it is called base editing, and works in a more efficient way. Instead of snipping DNA strands and replacing removed bits with desired traits, the new method does nothing more than swap DNA letters—trading out an A for a G, for example. In this new effort, the researchers used this new method to correct a gene mutation that results in humans having a condition called Marfan syndrome, in which people have an A instead of a G in the FBN1 gene. It is a disorder that causes problems with connective tissue, leading to a myriad of problems for those born with it.

The new research is unique in that the scientists used viable embryos created using in vitro fertilization. The team could have implanted these viable gene-edited embryos into a woman’s uterus, had they chosen to do so.

I don’t know about you, but I had to look them both up to get a solid understanding of these terms. Of course, these ideas aren’t new. And the brave new world of biohacking, I mean grinder biohacking, is fodder for edgy and future forward media outlets as well as the nightly news. What interests me is the shift to a more commonplace reference like Gartner report. Their analysis of over 2,000 innovations from quantum computing to augmented reality, lead them to choose that fine line between man and machine. It’s important and a bold wake-up call to humanity.

Is humanity about to enter its greatest point of transformation?

To understand how cells in the body behave, bioengineers create miniature models of the cells’ environment in their lab. But recreating this niche environment is incredibly complex in a controlled setting, because researchers are still learning all the factors that influence cell behavior and growth. By observing and then modifying their engineered mini-models, scientists are better able to identify those factors.

This form of cellular research is essential to the study of regenerative medicine, which focuses on replacing or repairing damaged tissue, often through the use of stem cells, a special population of cells that can give rise to all tissues in the body. Bioengineers face the central question of regenerative medicine: what causes stem cells to grow, organize, and mature from a small population of cells to complex organs?

To find an answer, a research team from the Johns Hopkins Institute for NanoBioTechnology borrowed a process commonly used in the electronics industry called micropatterning, in which the miniaturization of shapes increases the number of transistors on a circuit. The team created micropatterned shapes, coupled with machine learning, to see how confinement influences stem cell maturation and organization.

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