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Category: 3D printing – Page 128

A 3D-printed layered structure that incorporates neural cells to mimic the structure of brain tissue has been created by researchers at the ARC Centre of Excellence for Electromaterials Science (ACES) in Australia, and it could have major consequences in studying and treating conditions such as schizophrenia and Alzheimer’s. The three-dimensional structure will allow scientists to better understand the complex nature of the brain and its 86 billion nerve cells. We look at the benefits and risks of this scientific breakthrough on the Lip News with Jose Marcelino Ortiz and Jo Ankier.

http://motherboard.vice.com/read/researchers-are-getting-clo…ing-brains

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At the end of last year, Davide Sher predicted that 2016 would see metal 3D printing move from a technology capable of producing small batches to a fully-automated method for serial manufacturing. Davide cited a number of machines in development that herald the age of serial metal 3D printing, but he may have left one system out: the Hyproline platform.

TNO Hyproline PrintValley metal 3D printer

The Hyproline is the result of an EU additive manufacturing initiative began in 2012 to create a high-performance production line for small series metal parts. After several years, the group of industry partners involved, including researcher organization TNO and Swedish metal printer manufacturer Höganäs, have finalized the Hyproline system. The machine uses a similar platform as TNO’s PrintValley, which involves a conveyor belt mechanism to pass multiple build plates beneath a print head. The result is an automated assembly line that can produce a variety of custom parts at high speed.

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Nanoparticles form in a 3-D-printed microfluidic channel. Each droplet shown here is about 250 micrometers in diameter, and contains billions of platinum nanoparticles. (credit: Richard Brutchey and Noah Malmstadt/USC)

USC researchers have created an automated method of manufacturing nanoparticles that may transform the process from an expensive, painstaking, batch-by-batch process by a technician in a chemistry lab, mixing up a batch of chemicals by hand in traditional lab flasks and beakers.

Consider, for example, gold nanoparticles. Their ability to slip through the cell’s membrane makes them ideal delivery devices for medications to healthy cells, or fatal doses of radiation to cancer cells. But the price of gold nanoparticles at $80,000 per gram, compared to about $50 for pure raw gold goes.

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Just Amazing

Ralph Mobbs, a neurosurgeon at the Prince of Wales Hospital in Sydney, made medical history in late 2015 when he successfully replaced two vertebrae with custom made prosthesis. The patient, in his 60s, suffered from Chordoma, a particularly nasty form of cancer that had formed on his top two vertebrae and threatened to cinch off his spinal cord as it grew. That would have left him a quadriplegic. Complicating matters, those top two vertebrae are what allow you to turn and tilt your head, so it’s not like doctors can easily fashion a replacement out of bone grafted from another part of the patient’s body. They have to fit perfectly and that’s where the 3D printers come in.

Mobbs worked with Anatomics, an Australian medical device manufacturer, to craft perfect replicas of the patient’s top two vertebrae out of titanium. This is the first time that these two particular neck bones have been printed and installed. “To be able to get the printed implant that you know will fit perfectly because you’ve already done the operation on a model … It was just a pure delight,” Mobbs told Mashable Australia. “It was as if someone had switched on a light and said ‘crikey, if this isn’t the future, well then I don’t know what is’.”

The surgery itself was no small feat. The 15-hour procedure is fraught with peril as the medical team operates within inches of the top of the spinal cord as well as the brainstem and numerous major arteries. “The surgery that we’re doing today is a particularly complicated and long and difficult surgery. It involves exposure at the top of the neck where the neck and the head meets,” Mobbs told ABC 7.30. “It’s essentially disattaching the patient’s head from his neck and taking the tumour out and reattaching his head back onto his neck.” Thankfully, the surgery was a success. Mobbs was able to remove the tumor and implant the prosthetic.

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Completed ear and jaw bone structures printed with the Integrated Tissue-Organ Printing System (credit: Wake Forest Baptist Medical Center)

Using a sophisticated, custom-designed 3D printer, regenerative medicine scientists at Wake Forest Baptist Medical Center have proved that it is feasible to print living tissue structures to replace injured or diseased tissue in patients.

Reporting in Nature Biotechnology, the scientists said they printed ear, bone and muscle structures. When implanted in animals, the structures matured into functional tissue and developed a system of blood vessels. Most importantly, these early results indicate that the structures have the right size, strength and function for use in humans.

“This novel tissue and organ printer is an important advance in our quest to make replacement tissue for patients,” said Anthony Atala, M.D., director of the Wake Forest Institute for Regenerative Medicine (WFIRM) and senior author on the study. “It can fabricate stable, human-scale tissue of any shape. With further development, this technology could potentially be used to print living tissue and organ structures for surgical implantation.”

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MOFFETT FIELD, California — Within five years, companies could begin in-orbit manufacturing and assembly of communications satellite reflectors or other large structures, according to Made in Space, the Silicon Valley startup that sent the first 3D printer to the International Space Station in 2014.

As Made in Space prepares to send a second 3D printer into orbit, the company is beginning work with Northrop Grumman and Oceaneering Space Systems on Archinaut, an ambitious effort to build a 3D printer equipped with a robotic arm that the team plans to install in an external space station pod, under a two-year, $20 million NASA contract. The project will culminate in 2018 with an on-orbit demonstration of Archinaut’s ability to additively manufacture and assemble a large, complex structure, said Andrew Rush, Made in Space president.

NASA’s selected the Archinaut project, officially known as Versatile In-Space Robotic Precision Manufacturing and Assembly System, as part of its Tipping Points campaign, which funds demonstrations of space-related technologies on the verge of offering significant payoffs for government and commercial applications. Archinaut was one of three projects NASA selected in November that focus on robotic manufacturing and assembly of spacecraft and structures in orbit.

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UC Berkeley engineers created a “smart cap” using 3-D-printed plastic with embedded electronics to wirelessly monitor the freshness of milk (credit: Photo and schematic by Sung-Yueh Wu)

UC Berkeley engineers, in collaboration with colleagues at Taiwan’s National Chiao Tung University, have developed a 3D printing process for creating basic electronic components, such as resistors, inductors, capacitors, and integrated wireless electrical sensing systems.

As a test, they printed a wireless “smart cap” for a milk carton that detected signs of spoilage using embedded sensors.

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