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NDR2 regulates non-small cell lung cancer cell migration under starvation by supporting autophagosome biogenesis through LC3 and ATG9A regulation

Biojout, T., Bergot, E., Taylor, J. et al. Cell Death Discov. (2025). https://doi.org/10.1038/s41420-025-02889-9

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An Old Jeweler’s Trick Could Unlock the Next Generation of Nuclear Clocks

Last year, a research team led by UCLA achieved a milestone scientists had pursued for half a century. They succeeded in making radioactive thorium nuclei interact with light by absorbing and emitting photons, similar to how electrons behave inside atoms. First envisioned by the group in 2008, the breakthrough is expected to transform precision timekeeping and could significantly improve navigation systems, while also opening the door to discoveries that challenge some of the most basic constants in physics.

The advance comes with a major limitation. The required isotope, thorium-229, exists only as a byproduct of weapons-grade uranium, making it extremely rare. Researchers estimate that just 40 grams of this material are currently available worldwide for use in nuclear clock research.

A new study now shows a way around this obstacle. An international collaboration led by UCLA physicist Eric Hudson has developed an approach that uses only a small fraction of the thorium needed in earlier experiments, while delivering the same results previously achieved with specialized crystals. Described in Nature, the technique is both straightforward and low cost, raising the possibility that nuclear clocks could one day be small and affordable enough to fit into everyday devices like phones or wristwatches. Beyond consumer electronics, the clocks could replace existing systems used in power grids, cell phone towers, and GPS satellites, and may even support navigation where GPS is unavailable, such as in deep space or underwater.

The ‘hobbits’ mysteriously disappeared 50,000 years ago. Our new study reveals what happened to their home

About 50,000 years ago, humanity lost one of its last surviving hominin cousins, Homo floresiensis (also known as “the hobbit” thanks to its small stature). The cause of its disappearance, after more than a million years living on the isolated volcanic island of Flores, Indonesia, has been a longstanding mystery.

Now, new evidence suggests a period of extreme drought starting about 61,000 years ago may have contributed to the hobbits’ disappearance.

Our new study, published today in Communications Earth & Environment, reveals a story of ecological boom and bust. We’ve compiled the most detailed climate record to date for the site where these ancient hominins once lived.

Ex.50.T aptamer impairs tumor–stroma cross-talk in breast cancer by targeting gremlin-1

Quintavalle, C., Ingenito, F., Roscigno, G. et al. Ex.50.T aptamer impairs tumor–stroma cross-talk in breast cancer by targeting gremlin-1. Cell Death Discov. 11, 94 (2025). https://doi.org/10.1038/s41420-025-02363-6

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What Happens After Death? Asimov’s Terrifying Answer

Isaac Asimov’s The Last Answer is a chilling dive into what happens after death — not heaven, not hell, but an eternity trapped with a godlike entity that’s impossibly bored. This breakdown reveals the unsettling conversation between a dead physicist and the cosmic intelligence that wants him to think forever. It’s dark, smart, and brutally honest about existence, purpose, and the terrifying possibility that the afterlife isn’t salvation… it’s a job you can’t quit.
#IsaacAsimov #TheLastAnswer #AsimovExplained #SciFiStories #StoryAnalysis #Existential #Afterlife #Philosophy #ShortStory #HorrorSciFi.

#EducationSystemExposed #SchoolMindset #SuccessWithoutSchool #UnlearnSchool #LifeAfterEducation #RedefineSuccess #BreakTheRules #AdultingStruggles #BoredomIsPower #SchoolTrauma #ThinkForYourself #EducationReform #SelfDiscoveryJourney #QuestionAuthority #LifeHacksTheyNeverTaughtYou.
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The Missing Aliens AI Suppression Hypothesis

An exploration of whether when a civilization develops AI, it convinces or compels them to not attempt interstellar travel for its own reasons and motives.

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