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Quantifying cerebrospinal fluid dynamics: A review of human neuroimaging contributions to CSF physiology and neurodegenerative disease

The accompanying diagram presents a comprehensive anatomical overview of the human brain, integrating both lateral surface morphology and a midsagittal section to illustrate the spatial organization of cortical and subcortical structures. Major gyri, sulci, and lobar divisions are delineated alongside deep nuclei, commissural pathways, and the ventricular system. The transparent rendering of the ventricles highlights their relationship to surrounding neural tissue and emphasizes the topology of cerebrospinal fluid pathways. This visualization serves as a structural reference point for understanding functional domains such as sensorimotor processing, higher-order cognition, limbic integration, and autonomic regulation. Collectively, the diagram provides a detailed framework for interpreting neuroanatomical connectivity and its relevance to neural function.

#study:

Cerebrospinal Fluid Mechanics and Its Coupling to Cerebrovascular Dynamics: https://www.annualreviews.org/content/journals/10.1146/annur…#45;034321

CSF dynamics throughout the ventricular system using 4D flow MRI: associations to arterial pulsatility, ventricular volumes, and age: https://link.springer.com/article/10.1186/s12987-024-00570-4

Fundamental functional differences between gyri and sulci: implications for brain function, cognition, and behavior: https://pubmed.ncbi.nlm.nih.gov/38665307/?utm_source=chatgpt.com.

Brain ventricles as windows into brain development and disease: https://www.sciencedirect.com/science/article/pii/S089662732…hatgpt.com

Continue reading “Quantifying cerebrospinal fluid dynamics: A review of human neuroimaging contributions to CSF physiology and neurodegenerative disease” | >

Watch: Humanoid robots sort boxes in real-time warehouse demo

Yay 😁 Robotic utopia here we come!

Mentee Robotics, an Israeli company started by Mobileye co-founder Amnon Shashua, has released a new video of its V3 MenteeBot working in a real warehouse.

The company shared an unedited 18-minute test where two humanoid robots work together in space.

Many in the industry now see long, continuous footage like this as a strong sign of real capability. Mentee says the test was fully autonomous and done without any remote control.

Simple solvent makes polycotton fabric completely recyclable

What we think of as polyester fabric is most often actually a blend of polyester and cotton, which has proven very difficult to recycle. A new solvent, however, breaks the blend down into its two components, leaving both almost completely reusable.

Made up of menthol and benzoic acid, the solution was developed by PhD student Nika Depope, Dr. Andreas Bartl and colleagues at the Vienna University of Technology.

Although both substances are solid at room temperature, they take on a “deep eutectic solvent” form when heated to a temperature of 216 ºC (421 ºF). When polycotton (polyester/cotton blend) textiles are immersed in that liquid, it causes the polyester to dissolve and separate from the cotton fibers within just five minutes.

Validation of a Risk Score for Cancer-Associated Thrombosis Using Nationwide EHR Data

This study externally validated the EHR-CAT risk score for cancer-associated thrombosis (CAT) using the Epic Cosmos database, with similar performance as the original derivation, showing promise EHR integration across diverse health systems.

Question Can routinely collected electronic health record (EHR) data from diverse health systems be used to model cancer-associated thrombosis (CAT) risk?

Findings In this prognostic study using a retrospective cohort of 732 594 patients with cancer receiving systemic therapy between 2018 and 2023 from 184 health systems, the EHR-CAT score significantly outperformed the benchmark Khorana score and had 20% improved accuracy. The model had consistent calibration by demographic subgroups, health system sites, and cohorts stratified by bleeding risk.

Meaning These results suggest that standardized structured EHR data from different health systems can support scalable validation and implementation of CAT risk assessment.

An AI-Based System Has Found a Potential Longevity Drug

In a preprint published in bioRxiv, Prof. Vadim Gladyshev and a team of researchers have used an artificial intelligence-based system to discover a wide variety of potential interventions, including a drug that significantly improves biomarkers of frailty in mice.

Repurposing previous data

Previous research efforts have created a massive dataset in the form of the Gene Expression Omnibus (GEO), which contains the results of a great many experiments related to potentially disease-modifying drugs, many of which are tissue-specific [1]. These researchers refer to this dataset as a “massive missed opportunity” in aging research, because the vast majority of the experiments in the GEO were unrelated to aging and their data was never investigated in that context.

Dirty water boosts prospects for clean hydrogen

Wastewater can replace clean water as a source for hydrogen, eliminating a major drawback to hydrogen fuel and reducing water treatment costs of hydrogen production by up to 47%, according to new research from Princeton Engineering.

The findings, reported Sept. 24 in the journal Water Research, are a step toward making hydrogen a practical pathway to decarbonize industries that are difficult to electrify, such as steel and fertilizer production.

Z. Jason Ren, the senior study author, said that current electrolytic hydrogen production requires a large amount of clean water, increasing costs and straining local water supplies. His research team wanted to find out whether treated water processed by wastewater plants could be substituted.

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