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Antimicrobial resistance: a concise update

Antimicrobial resistance (AMR) is a serious threat to global public health, with approximately 5 million deaths associated with bacterial AMR in 2019. Tackling AMR requires a multifaceted and cohesive approach that ranges from increased understanding of mechanisms and drivers at the individual and population levels, AMR surveillance, antimicrobial stewardship, improved infection prevention and control measures, and strengthened global policies and funding to development of novel antimicrobial therapeutic strategies.

Dark energy might be changing and so is the Universe

Dark energy may be alive and changing, reshaping the cosmos in ways we’re only beginning to uncover. New supercomputer simulations hint that dark energy might be dynamic, not constant, subtly reshaping the Universe’s structure. The findings align with recent DESI observations, offering the strongest evidence yet for an evolving cosmic force.

Since the early 20th century, scientists have gathered convincing evidence that the Universe is expanding — and that this expansion is accelerating. The force responsible for this acceleration is called dark energy, a mysterious property of spacetime thought to push galaxies apart. For decades, the prevailing cosmological model, known as Lambda Cold Dark Matter (ΛCDM), has assumed that dark energy remains constant throughout cosmic history. This simple but powerful assumption has been the foundation of modern cosmology. Yet, it leaves one key question unresolved: what if dark energy changes over time instead of remaining fixed?

Recent observations have started to challenge this long-held view. Data from the Dark Energy Spectroscopic Instrument (DESI) — an advanced project that maps the distribution of galaxies across the Universe — suggests the possibility of a dynamic dark energy (DDE) component. Such a finding would mark a significant shift from the standard ΛCDM model. While this points to a more intricate and evolving cosmic story, it also exposes a major gap in understanding: how a time-dependent dark energy might shape the formation and growth of cosmic structures remains unclear.

New Quantum Algorithm Could Explain Why Matter Exists at All

Researchers used IBM’s quantum computers to create scalable quantum circuits that simulate matter under extreme conditions, offering new insight into fundamental forces and the origins of the universe. Simulating how matter behaves under extreme conditions is essential for exploring some of the d

A new way to trigger responses in the body

Researchers at the University of Tokyo developed an experimental method to induce a strong physiological response linked to psychological pressure by making participants aim for a streak of success in a task. Their findings suggest this approach reproduces pressurelike conditions in a laboratory setting more effectively than traditional methods, affording easier access to the study of this state. That in turn could open up research into how pressure influences human performance in physical and intellectual tasks.

Whether in an exam hall or on the field, to “crack” under pressure is a common trope. But what’s the reality behind this idea? It’s easy to assume that with greater pressure comes greater chance of losing your composure. To know, then, how to overcome this could yield greater performance benefits. But the path to study such ideas is far from simple. Being rigorous in the field of psychology is extremely difficult, as there are limitless factors that can impact different people in different ways. Previous experimental methods have been limited in that they failed to induce strong physiological arousal.

Driven by such limitations and an urge to better understand the impacts of pressure on performance, Professor Kazutoshi Kudo and his team at the University of Tokyo’s Graduate School of Arts and Sciences set out to devise a better method. Their aim was to find how to produce strong physiological arousal in subjects in ways that allowed them to isolate the effects of different kinds of tasks, so that the nature of the tasks, settings and other variables could be methodically measured and accounted for. It was also important for them that their method could exist at larger scales than is often possible for tests and trials in this field.

This 250-Year-Old Whale Might Hold the Key to Human Longevity

Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/
Timestamps:
00:00 Intro.
00:41 DNA damage and aging.
01:37 Why bowhead whales live so long.
03:13 Cold shock proteins and lifespan.
04:43 Body temperature and longevity.
06:50 Acute cold exposure benefits.
08:10 Takeaway.

100 Health Biomarkers Ranked: https://youtu.be/SgKp5mm0ALI?si=M7YkYo6Lelci7kOQ

Start rewinding your biological clock: https://www.siimland.co/course.

P.S. This is not professional medical advice and should not be taken as such. The creator of this video is not held accountable for your health. Consult your doctor first.

DNA polymerase β suppresses somatic indels at CpG dinucleotides in developing cortical neurons

New research finds that dying cells leave a “footprint of death” that guides immune responses — but viruses like influenza can exploit this signaling. The discovery, published in Nature Communications, offers new insight into cell death, viral transmission, and potential drug targets.


New insights into the aftermath of cell death might ultimately inform drug development.

Antarctic ice loss linked to ‘storms’ at ocean’s subsurface

Researchers at the University of California, Irvine and NASA’s Jet Propulsion Laboratory have identified stormlike circulation patterns beneath the Antarctic ice shelves that are causing aggressive melting, with major implications for global sea level rise projections.

In a paper published recently in Nature Geoscience, the scientists say their study is the first to examine ocean-induced ice shelf melting events from a weather timescale of just days versus seasonal or annual timeframes. This enabled them to match “ocean storm” activity with intense ice melt at Thwaites Glacier and Pine Island Glacier in the climate change-threatened Amundsen Sea Embayment in West Antarctica.

The research team relied on climate simulation modeling and moored observation tools to gain 200-meter-resolution pictures of submesoscale ocean features between 1 and 10 kilometers across, tiny in the context of the vast ocean and huge slabs of floating ice in Antarctica.

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