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Sons of mothers with type 1 diabetes show early signs of vascular dysfunction

“Our work shows that vascular function is affected before metabolic dysfunction appears, which challenges current assumptions,” the last author of the study.

The study found that the dysfunction is driven by oxidative stress in endothelial cells, a potential early sign of future cardiovascular disease. The findings could help clinicians better assess risk and focus on preventive measures.

“We observed that early intervention can restore vascular function in affected animals, pointing to new opportunities for disease prevention later in life,” adds the first author.

A new study i reveals that sons born to mothers with type 1 diabetes may develop early vascular dysfunction – independently of metabolic health. The finding, published in Cell Reports Medicine, may help shape future strategies to prevent cardiovascular disease early in life.

Children of women with type 1 diabetes are known to be at increased risk of developing cardiovascular diseases. This new study is, according to the researchers, the first to show that the risk is linked to early dysfunction in blood vessel cells in sons, even before any metabolic issues arise.

Researchers used a combination of animal models, Swedish and Danish health registries, and a small clinical study to explore the link. Results show a sex-specific effect: only sons displayed early vascular changes.

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Bridging or Direct Thrombectomy in Posterior Circulation Large-Vessel Occlusion StrokeAnalysis of Binational Registries and Meta-Analysis

Class III evidence that in patients with posterior circulation stroke undergoing thrombectomy, previous IV thrombolysis is associated with better 90-day functional outcomes and lower mortality without increasing hemorrhagic risk.

Background and Objectives.

A Mysterious Bridge Between Life and Death

How does the discovery of the third state challenge traditional definitions of life and death, and what implications does this have for our understanding of biology? In what ways could the third state revolutionize medical treatments, and what ethical considerations might arise from using postmortem cells for therapeutic purposes? What role might the third state play in the evolution of life, and how could this influence the way we study and interpret changes in living organisms over time? Using these questions as inspiration, create a detailed essay exploring the scientific, medical, and philosophical implications of the third state. Once completed, share your essay to discuss your insights with us!

NVIDIA Partners With Mistral AI to Accelerate New Family of Open Models

Today, Mistral AI announced the Mistral 3 family of open-source multilingual, multimodal models, optimized across NVIDIA supercomputing and edge platforms.

Mistral Large 3 is a mixture-of-experts (MoE) model — i nstead of firing up every neuron for every token, it only activates the parts of the model with the most impact. The result is efficiency that delivers scale without waste, accuracy without compromise and makes enterprise AI not just possible, but practical.

Mistral AI’s new models deliver industry-leading accuracy and efficiency for enterprise AI. It will be available everywhere, from the cloud to the data center to the edge, starting Tuesday, Dec. 2.

Lifeboat Foundation Guardian Award 2025: Professor Roman V. Yampolskiy

The Lifeboat Foundation Guardian Award is annually bestowed upon a respected scientist or public figure who has warned of a future fraught with dangers and encouraged measures to prevent them.

This year’s winner is Professor Roman V. Yampolskiy. Roman coined the term “AI safety” in a 2011 publication titled * Artificial Intelligence Safety Engineering: Why Machine Ethics Is a Wrong Approach*, presented at the Philosophy and Theory of Artificial Intelligence conference in Thessaloniki, Greece, and is recognized as a founding researcher in the field.

Roman is known for his groundbreaking work on AI containment, AI safety engineering, and the theoretical limits of artificial intelligence controllability. His research has been cited by over 10,000 scientists and featured in more than 1,000 media reports across 30 languages.

Watch his interview on * The Diary of a CEO* at [ https://www.youtube.com/watch?v=UclrVWafRAI](https://www.youtube.com/watch?v=UclrVWafRAI) that has already received over 11 million views on YouTube alone. The Singularity has begun, please pay attention to what Roman has to say about it!

Professor Roman V. Yampolskiy who coined the term “AI safety” is winner of the 2025 Guardian Award.

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Breast cancer remodels lymphatic vessels to accelerate its spread, research reveals

Breast cancer is able to modify the lymphatic vessels through which it travels to the draining lymph nodes. From there, it can then spread to other parts of the body. A new finding by Finnish researchers may help develop targeted therapies that could prevent this spread.

The findings have been published in Nature Communications.

The most dangerous feature of breast cancer is its ability to spread elsewhere in the body. Usually, the first sign of metastasis is that cancer cells are also found in the lymph nodes draining the tumor area. The first lymph nodes that cancer cells can reach via the lymphatic vessels are located in the armpit.

Extracellular Vesicles as Novel Biomarkers for Tumor Association in Intermediate-Risk Paraneoplastic Neurologic Syndromes

Class IV evidence that higher circulating blood levels of extracellular vesicles can distinguish between tumor-associated paraneoplastic neurologic syndrome (PNS) from suspected PNS without tumor.

Background and Objectives.

Open-source framework enables addition of AI to software without prompt engineering

Developers can now integrate large language models directly into their existing software using a single line of code, with no manual prompt engineering required. The open-source framework, known as byLLM, automatically generates context-aware prompts based on the meaning and structure of the program, helping developers avoid hand-crafting detailed prompts, according to a conference paper presented at the SPLASH conference in Singapore in October 2025 and published in the Proceedings of the ACM on Programming Languages.

“This work was motivated by watching developers spend an enormous amount of time and effort trying to integrate AI models into applications,” said Jason Mars, an associate professor of computer science and engineering at U-M and co-corresponding author of the study.

Audio-augmented wearable aims to improve mindfulness, with possible benefits for those with anxiety and ADHD

A new device uses focused sound cues to keep users grounded amid digital distractions, with possible benefits for anxiety and ADHD as well.

The whisper of two palms rubbing together. The squeak of a marker on a whiteboard. The swish of fabric against fabric. The whoosh of a running faucet. These sounds can help center the mind on the present moment.

Such cues were the driving force of new research from Stanford’s SHAPE Lab and the Virtual Human Interaction Lab, which has created a new device they believe can improve mindfulness in an all-too-distracting digital world. The secret is that the keys to mindfulness have been right in front of our ears all along, hidden in the often subtle, overlooked audio cues that help ground us in the beauty and meaning of everyday experiences.

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