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One-hour saliva test spots biomarker linked to several cancers
QUT researchers have developed a simple one-hour saliva test for a protein biomarker that has been linked with oral, colon and pancreatic cancers. The findings are published in the journal Talanta.
The paper is titled “Label free paper sensor and light driven material for the rapid screening of S100P cancer biomarker in saliva.” Corresponding author, Associate Professor Emad Kiriakous, from QUT’s School of Chemistry and Physics, said this technology could pave the way for simple, low-cost, point-of-care screening tools to help identify and treat cancer early.
Professor Kiriakous said the QUT team developed a rapid testing technique of saliva using paper coated in gold and silver nanoparticles to create a highly sensitive sensor that records the Raman spectrum (or SERS, the process by which a substance scatters laser light which is used to identify molecules) of saliva samples.
Myocarditis and look-alikes: when the diagnosis matters
Myocarditis is an inflammatory disease of the heart muscle that can be triggered by various causes, including viruses, autoimmune response, molecular mimicry and exposure to immune-stimulating drugs or vaccines. Most cases of myocarditis heal, and cardiac dysfunction, if present, recovers; however, selected forms may require targeted therapy to improve outcomes. We herein review five conditions presenting with or mimicking myocarditis that require targeted diagnostic approaches, including endomyocardial biopsy, and/or targeted treatments. Giant cell myocarditis is an intense and unresolving inflammation of the heart, characterised by rapid progression, significant arrhythmias, heart failure and shock, that is unlikely to resolve without immunosuppression therapy.
Chemical recycling of imine-linked covalent organic frameworks
Imine-linked covalent organic frameworks (COFs) have been explored for various applications; however, chemical recycling of end-of-life COFs is an undeveloped area of research. Here, we report closed-loop recycling methods for imine-linked COFs, realizing their chemical depolymerization and reconstruction through d.
Variant Resolution Through RNA Testing and Affected Tissue Analysis in the NeurofibromatosesA Case Series
Abstract. The heart, a vital organ, works without interruption and constantly adjusts to the ever-changing demands on our body. It adapts to physiological and pathological changes, including exercise and emotional state, as well as metabolic, respiratory, and vascular abnormalities. The pumping action of the heart is determined by the health of the myocardium, which undergoes changes with ageing that are both under-investigated and incompletely understood, potentially impacting our approach to pathological conditions. Here, the alterations in cellular, tissue, and gross physiological function of the heart with age are discussed. At the molecular level, non-coding RNAs influence cellular senescence, and extracellular vesicles induce fibrosis through matrix remodelling. Mitochondrial dysfunction and altered fatty acid oxidation reduce cellular energetics, whilst accumulation of reactive oxygen species and steatosis, as well as telomere shortening coupled with reduced autophagy, limit the myocardium’s regenerative capability. Loss of cardiomyocytes, combined with senescence, requires compensatory hypertrophy, inducing myocardial stiffness and altered muscle function. In addition to these direct alterations in myocardial characteristics with ageing, other factors that can affect the myocardium indirectly are addressed, including valve calcification, resulting in regurgitation and/or stenosis; vascular abnormalities, reducing compliance and exacerbating hypertension; fibrosis leading to cardiac arrhythmias; and autonomic dysregulation, reducing cardiac adaptability. Finally, potential modulation of cardiac ageing is discussed whilst also addressing which senescent modifications should be considered as ageing-related physiological changes of the myocardium. A better understanding of myocardial ageing will differentiate physiological changes from early, preventable, and reversible pathological changes, consequently helping to optimize management of individuals with or at risk of myocardial disease by taking into account diverse trajectories of myocardial ageing.
Effect of Tocilizumab on Pro–B-Type Natriuretic Peptide and Infarct Size in Patients With Acute Myocardial Infarction at Risk of Cardiogenic Shock (DOBERMANN-T)
Early IL-6 receptor inhibition with tocilizumab in AMI patients at increased risk of CS safely suppressed systemic inflammation but had an inconclusive effect on NT-proBNP, with a trend toward a favorable effect that did not reach statistical significance. No difference in LV infarct size as assessed with CMR was observed compared with placebo. JACC CRT2026.
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