There is a challenge related to prostate cancer from cancer cells that form resistance to treatments as the disease progresses. For medical science, these resistance mechanisms are not yet fully understood.
A new study by the University of Eastern Finland has filled some of this knowledge gap. The scientists found that inflammation-promoting immune cells, M1 macrophages, can transform cancer cells into stem-like cells and thus immune to treatment.
The study examined the impact of factors promoting inflammation in a tumour microenvironment on the progression of prostate cancer. Researchers focused particularly on the role of M1 and M2 macrophages in the tumour microenvironment. Macrophages are immune cells whose large number in the tumour area is often a sign of poor prognosis in relation to prostate cancer. These white blood cells stimulate the action of other immune system cells.
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