Cedars-Sinai investigators have identified several steps in a cellular process responsible for triggering one of the body’s important inflammatory responses. Their findings, published in the journal Science Immunology, open up possibilities for modulating the type of inflammation associated with several infections and inflammatory diseases.
Specifically, the investigators have improved understanding of the steps that lead to the production of IL-1 beta, a potent inflammatory protein signal released during many inflammatory responses.
“We now have a clearer understanding of the stepwise process that leads to the production of IL-1 beta,” said Andrea Wolf, Ph.D., assistant professor of Biomedical Sciences and Medicine at Cedars-Sinai, and a senior and corresponding author on the new study. “By understanding the process, we hope to one day find a treatment for diseases associated with this inflammatory response.”
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