Type 1 diabetes (T1D) is an autoimmune disease linked to helper T-cell recognition in non-obese diabetic (NOD) mice and humans. Moreover, T1D affects the endocrine pancreas, thus causing patients to be dependent on insulin replacement therapy for the rest of their lives. Monitoring disease progression through peripheral blood sampling could provide insights into the immune-mediated mechanisms of T1D.
In a recent study published in Science Translational Medicine, researchers profile antigen-specific helper clusters of differentiation 4-positive (CD4+) T-lymphocytes to determine anti-islet autoimmunity among mice and humans.
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