Summary: Treating a mouse model of multiple sclerosis (MS) with the pregnancy hormone estriol could reverse myelin breakdown in the brain’s cortex, a primary area affected in MS.
MS results in inflammation that damage the myelin coating around nerve fibers in the brain’s cortex, leading to disability worsening. Current MS treatments only target inflammation and can’t repair myelin damage.
However, the new study found that estriol not only prevented brain atrophy but also induced remyelination, suggesting it could repair MS-induced damage.
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