Some mutations were like a tax rebate and raised the propensity of TAR to adopt its biologically active structures, while other modifications raised the tax and decreased the odds that TAR would adopt a biologically active structure.
Hidden mechanism may lead to new drugs
“What we found was a hidden mechanism for controlling the activity of a molecule in a cell,” says Al-Hashimi. By altering the propensity of TAR to form biologically active states—by changing the tax rate—the researchers could fine-tune the molecule’s activity in cells.
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