Rheumatoid arthritis (RA), known as “immortal cancer,” is a chronic, progressive autoimmune inflammatory disease. The development and application of an RA high-sensitivity theranostics probe can help to accurately monitor the progression and realize the efficient treatment of RA.
In a study published in Advanced Science, a research group led by Prof. Zhang Yun from Fujian Institute of Research on the Structure of Matter of the Chinese Academy of Sciences developed a dual-triggered theranostics nanoprobe based on persistent luminescence nanoparticles (PLNPs) for RA autofluorescence-free imaging-guided precise treatment and therapeutic evaluation.
The researchers first prepared a renewable near-infrared (NIR)-emitting Zn1.3 Ga1.4 Sn0.3 O4:0.5%Cr3+, 0.3%Y3+ (ZGSO) PLNPs by a facile mesoporous silica template method.
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