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Aug 2, 2022

Distinct toll‐like receptor signaling in the salamander response to tissue damage

Posted by in category: biological

Circa 2021 This article states that humans have possibly an untapped regeneration ability and they may have found it in mice.


Using new phospho-flow cytometry techniques to measure signaling in individual cell subsets we compared mouse to salamander inflammation. These studies demonstrated evolutionarily conserved responses to PAMP ligands through toll-like receptors (TLRs) but identified key differences in response to DAMP ligands. Co-exposure of macrophages to DAMPs/PAMPs suppressed MAPK signaling in mammals, but not salamanders, which activate sustained MAPK stimulation in the presence of endogenous DAMPS.

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