In a new study, researchers have found that the zinc-finger transcription factor Slug is responsible for repressing p16Ink4a, a compound that promotes senescence in human tissue. The researchers suggest that Slug is worth exploring as a treatment for sarcopenia [1].
Satellite cells
Satellite cells are specialized stem cells that form new muscle cells when the muscle is injured [2]. Populations of satellite stem cells remain quiescent in normal muscle tissue, only becoming activated through physical damage of some sort. This allows the tissue to heal properly, restoring function and allowing for natural regeneration. However, in both humans and mice, old age leads to increased p16Ink4a, which causes defects in this regeneration [1].
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